ALAE_ECOL6
ID ALAE_ECOL6 Reviewed; 149 AA.
AC P64551; P76626;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=L-alanine exporter AlaE {ECO:0000255|HAMAP-Rule:MF_00914};
GN Name=alaE {ECO:0000255|HAMAP-Rule:MF_00914}; OrderedLocusNames=c3221;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Exports L-alanine. {ECO:0000255|HAMAP-Rule:MF_00914}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00914}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00914}.
CC -!- SIMILARITY: Belongs to the AlaE exporter family. {ECO:0000255|HAMAP-
CC Rule:MF_00914}.
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DR EMBL; AE014075; AAN81673.1; -; Genomic_DNA.
DR RefSeq; WP_000492656.1; NC_004431.1.
DR AlphaFoldDB; P64551; -.
DR STRING; 199310.c3221; -.
DR EnsemblBacteria; AAN81673; AAN81673; c3221.
DR GeneID; 66673460; -.
DR KEGG; ecc:c3221; -.
DR eggNOG; ENOG502ZRFS; Bacteria.
DR HOGENOM; CLU_126493_0_0_6; -.
DR OMA; ADWHQIA; -.
DR BioCyc; ECOL199310:C3221-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0034639; F:L-amino acid efflux transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032973; P:amino acid export across plasma membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00914; L_Ala_exporter; 1.
DR InterPro; IPR010574; Ala_export_AlaE.
DR Pfam; PF06610; AlaE; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..149
FT /note="L-alanine exporter AlaE"
FT /id="PRO_0000169304"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
SQ SEQUENCE 149 AA; 16949 MW; 0B1D31F498DBE4BC CRC64;
MFSPQSRLRH AVADTFAMVV YCSVVNMCIE VFLSGMSFEQ SFYSRLVAIP VNILIAWPYG
MYRDLFMRAA RKVSPSGWIK NLADILAYVT FQSPVYVAIL LVVGADWHQI MAAVSSNIVV
SMLMGAVYGY FLDYCRRLFK VSRYQQVKA