FND11_HUMAN
ID FND11_HUMAN Reviewed; 318 AA.
AC Q9BVV2;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Fibronectin type III domain-containing protein 11;
GN Name=FNDC11; Synonyms=C20orf195;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BVV2; Q10567-3: AP1B1; NbExp=3; IntAct=EBI-744935, EBI-11978055;
CC Q9BVV2; Q96KC2: ARL5B; NbExp=5; IntAct=EBI-744935, EBI-12885454;
CC Q9BVV2; Q13137: CALCOCO2; NbExp=4; IntAct=EBI-744935, EBI-739580;
CC Q9BVV2; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-744935, EBI-10171570;
CC Q9BVV2; P32320: CDA; NbExp=6; IntAct=EBI-744935, EBI-9250559;
CC Q9BVV2; Q9BXL8: CDCA4; NbExp=3; IntAct=EBI-744935, EBI-1773949;
CC Q9BVV2; P38936: CDKN1A; NbExp=3; IntAct=EBI-744935, EBI-375077;
CC Q9BVV2; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-744935, EBI-12261896;
CC Q9BVV2; Q9BW66: CINP; NbExp=3; IntAct=EBI-744935, EBI-739784;
CC Q9BVV2; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-744935, EBI-3866319;
CC Q9BVV2; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-744935, EBI-10175124;
CC Q9BVV2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-744935, EBI-618309;
CC Q9BVV2; Q86WP2: GPBP1; NbExp=11; IntAct=EBI-744935, EBI-2349758;
CC Q9BVV2; Q86WP2-4: GPBP1; NbExp=3; IntAct=EBI-744935, EBI-10300058;
CC Q9BVV2; O14964: HGS; NbExp=3; IntAct=EBI-744935, EBI-740220;
CC Q9BVV2; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-744935, EBI-2549423;
CC Q9BVV2; Q02363: ID2; NbExp=3; IntAct=EBI-744935, EBI-713450;
CC Q9BVV2; O76011: KRT34; NbExp=3; IntAct=EBI-744935, EBI-1047093;
CC Q9BVV2; Q6A162: KRT40; NbExp=3; IntAct=EBI-744935, EBI-10171697;
CC Q9BVV2; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-744935, EBI-12805508;
CC Q9BVV2; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-744935, EBI-741037;
CC Q9BVV2; P43365: MAGEA12; NbExp=6; IntAct=EBI-744935, EBI-749530;
CC Q9BVV2; Q99750: MDFI; NbExp=3; IntAct=EBI-744935, EBI-724076;
CC Q9BVV2; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-744935, EBI-1104552;
CC Q9BVV2; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-744935, EBI-742948;
CC Q9BVV2; P25786: PSMA1; NbExp=5; IntAct=EBI-744935, EBI-359352;
CC Q9BVV2; Q93062: RBPMS; NbExp=3; IntAct=EBI-744935, EBI-740322;
CC Q9BVV2; Q04864: REL; NbExp=3; IntAct=EBI-744935, EBI-307352;
CC Q9BVV2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-744935, EBI-748391;
CC Q9BVV2; Q9UHV2: SERTAD1; NbExp=3; IntAct=EBI-744935, EBI-748601;
CC Q9BVV2; Q16637: SMN2; NbExp=3; IntAct=EBI-744935, EBI-395421;
CC Q9BVV2; O60504: SORBS3; NbExp=3; IntAct=EBI-744935, EBI-741237;
CC Q9BVV2; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-744935, EBI-2212028;
CC Q9BVV2; P14373: TRIM27; NbExp=3; IntAct=EBI-744935, EBI-719493;
CC Q9BVV2; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-744935, EBI-947187;
CC Q9BVV2; O96006: ZBED1; NbExp=3; IntAct=EBI-744935, EBI-740037;
CC Q9BVV2; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-744935, EBI-12006434;
CC Q9BVV2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-744935, EBI-527853;
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DR EMBL; AL121829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000912; AAH00912.1; -; mRNA.
DR CCDS; CCDS13526.1; -.
DR RefSeq; NP_001306081.1; NM_001319152.1.
DR RefSeq; NP_001306082.1; NM_001319153.1.
DR RefSeq; NP_076964.1; NM_024059.3.
DR RefSeq; XP_011527343.1; XM_011529041.2.
DR AlphaFoldDB; Q9BVV2; -.
DR SMR; Q9BVV2; -.
DR BioGRID; 122493; 66.
DR IntAct; Q9BVV2; 45.
DR MINT; Q9BVV2; -.
DR STRING; 9606.ENSP00000480914; -.
DR iPTMnet; Q9BVV2; -.
DR PhosphoSitePlus; Q9BVV2; -.
DR BioMuta; FNDC11; -.
DR DMDM; 74761293; -.
DR MassIVE; Q9BVV2; -.
DR PaxDb; Q9BVV2; -.
DR PeptideAtlas; Q9BVV2; -.
DR PRIDE; Q9BVV2; -.
DR ProteomicsDB; 79235; -.
DR Antibodypedia; 29791; 112 antibodies from 20 providers.
DR DNASU; 79025; -.
DR Ensembl; ENST00000370097.2; ENSP00000359115.1; ENSG00000125531.7.
DR Ensembl; ENST00000370098.4; ENSP00000359116.3; ENSG00000125531.7.
DR Ensembl; ENST00000615526.1; ENSP00000480914.1; ENSG00000125531.7.
DR GeneID; 79025; -.
DR KEGG; hsa:79025; -.
DR MANE-Select; ENST00000370097.2; ENSP00000359115.1; NM_001319152.2; NP_001306081.1.
DR UCSC; uc002yfj.4; human.
DR CTD; 79025; -.
DR GeneCards; FNDC11; -.
DR HGNC; HGNC:28764; FNDC11.
DR HPA; ENSG00000125531; Tissue enriched (testis).
DR neXtProt; NX_Q9BVV2; -.
DR OpenTargets; ENSG00000125531; -.
DR PharmGKB; PA142672215; -.
DR VEuPathDB; HostDB:ENSG00000125531; -.
DR eggNOG; ENOG502QW8H; Eukaryota.
DR GeneTree; ENSGT00390000006008; -.
DR HOGENOM; CLU_049179_0_0_1; -.
DR InParanoid; Q9BVV2; -.
DR OMA; RFQRMKK; -.
DR OrthoDB; 1532862at2759; -.
DR PhylomeDB; Q9BVV2; -.
DR TreeFam; TF338188; -.
DR PathwayCommons; Q9BVV2; -.
DR SignaLink; Q9BVV2; -.
DR BioGRID-ORCS; 79025; 14 hits in 1061 CRISPR screens.
DR GenomeRNAi; 79025; -.
DR Pharos; Q9BVV2; Tdark.
DR PRO; PR:Q9BVV2; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BVV2; protein.
DR Bgee; ENSG00000125531; Expressed in left testis and 109 other tissues.
DR ExpressionAtlas; Q9BVV2; baseline and differential.
DR Genevisible; Q9BVV2; HS.
DR CDD; cd00063; FN3; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR039581; FNDC11.
DR PANTHER; PTHR14537; PTHR14537; 1.
DR Pfam; PF17744; DUF5581; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..318
FT /note="Fibronectin type III domain-containing protein 11"
FT /id="PRO_0000232867"
FT DOMAIN 210..307
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
SQ SEQUENCE 318 AA; 36526 MW; 9FDA08CB588A9699 CRC64;
MSTHVAGLGL DKMKLGNPQS FLDQEEADDQ QLLEPEAWKT YTERRNALRE FLTSDLSPHL
LKRHHARMQL LRKCSYYIEV LPKHLALGDQ NPLVLPSALF QLIDPWKFQR MKKVGTAQTK
IQLLLLGDLL EQLDHGRAEL DALLRSPDPR PFLADWALVE RRLADVSAVM DSFLTMMVPG
RLHVKHRLVS DVSATKIPHI WLMLSTKMPV VFDRKASAAH QDWARLRWFV TIQPATSEQY
ELRFRLLDPR TQQECAQCGV IPVAACTFDV RNLLPNRSYK FTIKRAETST LVYEPWRDSL
TLHTKPEPLE GPALSHSV
