FND3A_PONAB
ID FND3A_PONAB Reviewed; 1142 AA.
AC Q5RBN1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Fibronectin type-III domain-containing protein 3A;
GN Name=FNDC3A; Synonyms=FNDC3;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates spermatid-Sertoli adhesion during spermatogenesis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-
CC pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FNDC3 family. {ECO:0000305}.
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DR EMBL; CR858607; CAH90829.1; -; mRNA.
DR RefSeq; NP_001125472.1; NM_001132000.1.
DR AlphaFoldDB; Q5RBN1; -.
DR BMRB; Q5RBN1; -.
DR SMR; Q5RBN1; -.
DR STRING; 9601.ENSPPYP00000006111; -.
DR GeneID; 100172381; -.
DR KEGG; pon:100172381; -.
DR CTD; 22862; -.
DR eggNOG; ENOG502QRT8; Eukaryota.
DR InParanoid; Q5RBN1; -.
DR OrthoDB; 633003at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; -; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 7.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; SSF49265; 6.
DR PROSITE; PS50853; FN3; 9.
PE 2: Evidence at transcript level;
KW Acetylation; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..1142
FT /note="Fibronectin type-III domain-containing protein 3A"
FT /id="PRO_0000379877"
FT TRANSMEM 1121..1141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 212..313
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 317..409
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 413..506
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 510..604
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 608..701
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 705..795
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 805..894
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 895..989
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 990..1095
FT /note="Fibronectin type-III 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 104..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2H6"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BX90"
FT MOD_RES 157
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2H6"
FT MOD_RES 328
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2H6"
SQ SEQUENCE 1142 AA; 125728 MW; D1FAD0A2E461B289 CRC64;
MSGPAQVPMM SPNGSVPPIY VPPGYAPQVI EDNGVRRVVV VPQAPEFHPG GHTVLHRSPH
PPLPGFIPVP TMMPPPPRHM YSPVTGAGDM TTQYMPQYQS SQVYGDVDAH STHGRSNFRD
ERSSKTYERL QKKLKDRQGT QKDKMSSPPS SPQKCPSPIN EHNGLIKGQN AGGINTGSAK
IKSGKGKGGT QVDTEIEEKD EETKAFEALL SNIVKPVASD IQARTVVLTW SPPSSLINGE
TDESSVPELY GYEVLISSTG KDGKYKSVYI GEETNITLND LKPATDYHAK VQAEYNSIKG
TPSEAEIFTT LSCEPDIPNP PRIANRTKNS LTLQWKAPSD NGSKIQNFVL EWDEGKGNGE
FYQCYMGSQK QFKITKLSPA MGCKFRLSAR NDYGTSGFSE EVLYYTSGCA PSMPASPVLT
KAGITWLSLQ WSKPSGTPSD EGISYILEME EETSGYGFKP KYDGEDLAYT VKNLRRSTKY
KFKVIAYNSE GKSNPSEVVE FTTCPDKPGI PVKPSVKGKI HSHSFKITWD PPKDNGGAAI
NKYVVEMAEG SNGNKWEMIY SGATREHLCD RLNPGCFYRL RVYCISDGGQ SAVSESLLVQ
TPAVPPGPCL PPRLQGRPKA KEIQLRWGPP LVDGGSPISC YSVEMSPIEK DEPREVYQGS
EVECTVSSLL PGKTYSFRLR AANKMGFGPF SEKCDITTAP GPPDQCKPPQ VTCRSATCAQ
VNWEVPLSNG TDVTEYRLEW GGVEGSMQIC YCGPGLNYEI KGLSPATTYY CRVQALSVVG
AGPFSEVVAC VTPPSVPGIV TCLQEISDDE IENPHYSPST CLAISWEKPC DHGSEILAYS
IDSGDKQSLT VGKVTSYIIN NLQPDTTYRI RIQALNSLGA GPFSHVIKLK TKPLPPDPPR
LECVAFSHQN LKLKWGEGTP KTLSTDSIQY HLQMEDKNGR FVSLYRGPCH TYKVQRLNES
TSYKFCIQAC NEAGEGPVSQ EYIFTTPKSV PAALKAPKIE KVNDHICEIT WECLQPMKGD
PVIYSLQVML GKDSEFKQIY KGPDSSFRYS SLQLNCEYRF RVCAIRQCQD SLGHQDLVGP
YSTTVLFISQ RTEPPASTNR DTVESTRTRR ALSDEQCAAV NLVLFAFFSI LIAFIIQYFV
IK
