FND3B_HUMAN
ID FND3B_HUMAN Reviewed; 1204 AA.
AC Q53EP0; B2RB36; B3KXR8; D3DNQ7; Q5U5T8; Q6PIJ3; Q6UXG1; Q6UXZ5; Q8IXB2;
AC Q8NBU7; Q96D78; Q9H5I7; Q9NSQ8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Fibronectin type III domain-containing protein 3B;
DE AltName: Full=Factor for adipocyte differentiation 104;
DE AltName: Full=HCV NS5A-binding protein 37;
GN Name=FNDC3B; Synonyms=FAD104, NS5ABP37; ORFNames=UNQ2421/PRO4979/PRO34274;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, AND
RP VARIANT SER-179.
RC TISSUE=Carcinoma;
RX PubMed=15564382; DOI=10.1242/jcs.01546;
RA Tominaga K., Johmura Y., Nishizuka M., Imagawa M.;
RT "Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte
RT differentiation.";
RL J. Cell Sci. 117:6217-6226(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 320-1204 (ISOFORM 1), AND VARIANT SER-179.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-179.
RC TISSUE=Placenta, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-179.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP SER-179.
RC TISSUE=Lung, Skin, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 403-1204 (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 710-1204 (ISOFORM 1).
RA Wang L., Li K., Cheng J.;
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 728-1204 (ISOFORM 1).
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-1163, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP VARIANT [LARGE SCALE ANALYSIS] SER-927.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be a positive regulator of adipogenesis.
CC {ECO:0000269|PubMed:15564382}.
CC -!- INTERACTION:
CC Q53EP0-3; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-10242151, EBI-12318443;
CC Q53EP0-3; Q96I13: ABHD8; NbExp=3; IntAct=EBI-10242151, EBI-17180442;
CC Q53EP0-3; Q8IZF2: ADGRF5; NbExp=3; IntAct=EBI-10242151, EBI-7600130;
CC Q53EP0-3; Q9BXC9: BBS2; NbExp=3; IntAct=EBI-10242151, EBI-748297;
CC Q53EP0-3; Q6AI39: BICRAL; NbExp=3; IntAct=EBI-10242151, EBI-1012434;
CC Q53EP0-3; Q9NSI6-4: BRWD1; NbExp=3; IntAct=EBI-10242151, EBI-10693038;
CC Q53EP0-3; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-10242151, EBI-12809220;
CC Q53EP0-3; Q8WW14-2: C10orf82; NbExp=3; IntAct=EBI-10242151, EBI-12831628;
CC Q53EP0-3; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-10242151, EBI-11976299;
CC Q53EP0-3; Q8WYQ4-2: C22orf15; NbExp=3; IntAct=EBI-10242151, EBI-12030460;
CC Q53EP0-3; Q13557: CAMK2D; NbExp=3; IntAct=EBI-10242151, EBI-351018;
CC Q53EP0-3; Q6PRD7: CEMP1; NbExp=3; IntAct=EBI-10242151, EBI-12907646;
CC Q53EP0-3; A0PJW8: DAPL1; NbExp=3; IntAct=EBI-10242151, EBI-12840152;
CC Q53EP0-3; Q9Y6W6: DUSP10; NbExp=3; IntAct=EBI-10242151, EBI-3443946;
CC Q53EP0-3; Q86XJ1: GAS2L3; NbExp=3; IntAct=EBI-10242151, EBI-9248152;
CC Q53EP0-3; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-10242151, EBI-11956675;
CC Q53EP0-3; Q96G42: KLHDC7B; NbExp=3; IntAct=EBI-10242151, EBI-9478422;
CC Q53EP0-3; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10242151, EBI-1052037;
CC Q53EP0-3; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-10242151, EBI-11985629;
CC Q53EP0-3; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-10242151, EBI-12516603;
CC Q53EP0-3; P59942: MCCD1; NbExp=3; IntAct=EBI-10242151, EBI-11987923;
CC Q53EP0-3; Q14764: MVP; NbExp=3; IntAct=EBI-10242151, EBI-2816254;
CC Q53EP0-3; O14561: NDUFAB1; NbExp=5; IntAct=EBI-10242151, EBI-1246261;
CC Q53EP0-3; Q99570: PIK3R4; NbExp=3; IntAct=EBI-10242151, EBI-1046979;
CC Q53EP0-3; Q7Z3K3: POGZ; NbExp=6; IntAct=EBI-10242151, EBI-1389308;
CC Q53EP0-3; P78424: POU6F2; NbExp=3; IntAct=EBI-10242151, EBI-12029004;
CC Q53EP0-3; P54646: PRKAA2; NbExp=3; IntAct=EBI-10242151, EBI-1383852;
CC Q53EP0-3; Q04864-2: REL; NbExp=3; IntAct=EBI-10242151, EBI-10829018;
CC Q53EP0-3; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-10242151, EBI-6257312;
CC Q53EP0-3; Q99619: SPSB2; NbExp=3; IntAct=EBI-10242151, EBI-2323209;
CC Q53EP0-3; Q8NEQ6: SRARP; NbExp=3; IntAct=EBI-10242151, EBI-17858294;
CC Q53EP0-3; Q8N801-2: STPG4; NbExp=3; IntAct=EBI-10242151, EBI-12871202;
CC Q53EP0-3; P51687: SUOX; NbExp=3; IntAct=EBI-10242151, EBI-3921347;
CC Q53EP0-3; Q96M29: TEKT5; NbExp=3; IntAct=EBI-10242151, EBI-10239812;
CC Q53EP0-3; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-10242151, EBI-11139477;
CC Q53EP0-3; Q9Y4I5-2: TESMIN; NbExp=3; IntAct=EBI-10242151, EBI-12840664;
CC Q53EP0-3; Q6ZNM6: TEX43; NbExp=3; IntAct=EBI-10242151, EBI-18115728;
CC Q53EP0-3; A0A1B0GUV7: TEX48; NbExp=3; IntAct=EBI-10242151, EBI-18583507;
CC Q53EP0-3; O94842: TOX4; NbExp=6; IntAct=EBI-10242151, EBI-948613;
CC Q53EP0-3; Q12933: TRAF2; NbExp=3; IntAct=EBI-10242151, EBI-355744;
CC Q53EP0-3; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-10242151, EBI-17716262;
CC Q53EP0-3; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10242151, EBI-5235829;
CC Q53EP0-3; Q15645: TRIP13; NbExp=6; IntAct=EBI-10242151, EBI-358993;
CC Q53EP0-3; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-10242151, EBI-2514383;
CC Q53EP0-3; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-10242151, EBI-11975223;
CC Q53EP0-3; Q08AM6: VAC14; NbExp=3; IntAct=EBI-10242151, EBI-2107455;
CC Q53EP0-3; Q96E35: ZMYND19; NbExp=3; IntAct=EBI-10242151, EBI-746595;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q53EP0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q53EP0-2; Sequence=VSP_024741, VSP_024742;
CC Name=3;
CC IsoId=Q53EP0-3; Sequence=VSP_024739, VSP_024740;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in white adipose tissue
CC (WAT) especially in the stromal vascular cells. Expressed in adipocyte
CC differentiable 3T3-L1 cells but not in the non-adipogenic cell line
CC NIH-3T3. Expression increased in the early stage of adipogenesis.
CC {ECO:0000269|PubMed:15564382}.
CC -!- SIMILARITY: Belongs to the FNDC3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH12204.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH33635.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAQ88513.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAQ88733.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15639.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC11480.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB098597; BAC53727.1; -; mRNA.
DR EMBL; AY358146; AAQ88513.1; ALT_INIT; mRNA.
DR EMBL; AY358367; AAQ88733.1; ALT_INIT; mRNA.
DR EMBL; AK027052; BAB15639.1; ALT_INIT; mRNA.
DR EMBL; AK075220; BAC11480.1; ALT_INIT; mRNA.
DR EMBL; AK127826; BAG54580.1; -; mRNA.
DR EMBL; AK314478; BAG37083.1; -; mRNA.
DR EMBL; AK223599; BAD97319.1; -; mRNA.
DR EMBL; CH471052; EAW78476.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78472.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78474.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78475.1; -; Genomic_DNA.
DR EMBL; BC012204; AAH12204.1; ALT_INIT; mRNA.
DR EMBL; BC033635; AAH33635.1; ALT_INIT; mRNA.
DR EMBL; BC039297; AAH39297.1; -; mRNA.
DR EMBL; AF543840; AAN65261.1; -; mRNA.
DR EMBL; AL157482; CAB75672.1; -; mRNA.
DR CCDS; CCDS3217.1; -. [Q53EP0-1]
DR PIR; T46917; T46917.
DR RefSeq; NP_001128567.1; NM_001135095.1. [Q53EP0-1]
DR RefSeq; NP_073600.3; NM_022763.3. [Q53EP0-1]
DR AlphaFoldDB; Q53EP0; -.
DR SMR; Q53EP0; -.
DR BioGRID; 122288; 100.
DR IntAct; Q53EP0; 67.
DR MINT; Q53EP0; -.
DR STRING; 9606.ENSP00000338523; -.
DR iPTMnet; Q53EP0; -.
DR PhosphoSitePlus; Q53EP0; -.
DR BioMuta; FNDC3B; -.
DR DMDM; 146286181; -.
DR EPD; Q53EP0; -.
DR jPOST; Q53EP0; -.
DR MassIVE; Q53EP0; -.
DR MaxQB; Q53EP0; -.
DR PaxDb; Q53EP0; -.
DR PeptideAtlas; Q53EP0; -.
DR PRIDE; Q53EP0; -.
DR ProteomicsDB; 62442; -. [Q53EP0-1]
DR ProteomicsDB; 62443; -. [Q53EP0-2]
DR ProteomicsDB; 62444; -. [Q53EP0-3]
DR Antibodypedia; 2120; 139 antibodies from 23 providers.
DR DNASU; 64778; -.
DR Ensembl; ENST00000336824.8; ENSP00000338523.4; ENSG00000075420.13. [Q53EP0-1]
DR Ensembl; ENST00000415807.7; ENSP00000411242.2; ENSG00000075420.13. [Q53EP0-1]
DR Ensembl; ENST00000416957.5; ENSP00000389094.1; ENSG00000075420.13. [Q53EP0-1]
DR Ensembl; ENST00000421757.5; ENSP00000408496.1; ENSG00000075420.13. [Q53EP0-3]
DR Ensembl; ENST00000423424.5; ENSP00000392471.1; ENSG00000075420.13. [Q53EP0-3]
DR GeneID; 64778; -.
DR KEGG; hsa:64778; -.
DR MANE-Select; ENST00000415807.7; ENSP00000411242.2; NM_022763.4; NP_073600.3.
DR UCSC; uc003fhx.4; human. [Q53EP0-1]
DR CTD; 64778; -.
DR DisGeNET; 64778; -.
DR GeneCards; FNDC3B; -.
DR HGNC; HGNC:24670; FNDC3B.
DR HPA; ENSG00000075420; Low tissue specificity.
DR MIM; 611909; gene.
DR neXtProt; NX_Q53EP0; -.
DR OpenTargets; ENSG00000075420; -.
DR PharmGKB; PA134936830; -.
DR VEuPathDB; HostDB:ENSG00000075420; -.
DR eggNOG; KOG0613; Eukaryota.
DR GeneTree; ENSGT00940000157005; -.
DR HOGENOM; CLU_2739328_0_0_1; -.
DR InParanoid; Q53EP0; -.
DR OMA; CRAPCIS; -.
DR OrthoDB; 633003at2759; -.
DR PhylomeDB; Q53EP0; -.
DR TreeFam; TF316401; -.
DR PathwayCommons; Q53EP0; -.
DR SignaLink; Q53EP0; -.
DR BioGRID-ORCS; 64778; 39 hits in 1090 CRISPR screens.
DR ChiTaRS; FNDC3B; human.
DR GenomeRNAi; 64778; -.
DR Pharos; Q53EP0; Tbio.
DR PRO; PR:Q53EP0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q53EP0; protein.
DR Bgee; ENSG00000075420; Expressed in cartilage tissue and 202 other tissues.
DR ExpressionAtlas; Q53EP0; baseline and differential.
DR Genevisible; Q53EP0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; -; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 9.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; SSF49265; 5.
DR PROSITE; PS50853; FN3; 9.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1204
FT /note="Fibronectin type III domain-containing protein 3B"
FT /id="PRO_0000284891"
FT TRANSMEM 1182..1202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 278..377
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 381..473
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 477..570
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 574..669
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 673..765
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 766..859
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 871..957
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 958..1052
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1056..1153
FT /note="Fibronectin type-III 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 185..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 208
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 393
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NWW9"
FT MOD_RES 1163
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 63..71
FT /note="GPAEVPMMS -> DEVVKRACD (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024739"
FT VAR_SEQ 72..1204
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024740"
FT VAR_SEQ 618..629
FT /note="ANQWEVAYSGSA -> GEVFGNCFIQIQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_024741"
FT VAR_SEQ 630..1204
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_024742"
FT VARIANT 179
FT /note="T -> S (in dbSNP:rs7652177)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:15564382, ECO:0000269|Ref.5"
FT /id="VAR_031856"
FT VARIANT 927
FT /note="P -> S (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035921"
FT VARIANT 1080
FT /note="M -> V (in dbSNP:rs2276806)"
FT /id="VAR_047814"
FT CONFLICT 37
FT /note="Q -> H (in Ref. 2; AAQ88733)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="S -> R (in Ref. 1; BAC53727)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="S -> A (in Ref. 1; BAC53727)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="N -> D (in Ref. 3; BAG37083)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="S -> G (in Ref. 3; BAG37083)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="T -> A (in Ref. 3; BAG37083)"
FT /evidence="ECO:0000305"
FT CONFLICT 481
FT /note="P -> L (in Ref. 2; AAQ88513)"
FT /evidence="ECO:0000305"
FT CONFLICT 545
FT /note="K -> T (in Ref. 1; BAC53727)"
FT /evidence="ECO:0000305"
FT CONFLICT 676
FT /note="P -> S (in Ref. 4; BAD97319)"
FT /evidence="ECO:0000305"
FT CONFLICT 854
FT /note="C -> W (in Ref. 6; AAH39297)"
FT /evidence="ECO:0000305"
FT CONFLICT 895
FT /note="N -> D (in Ref. 3; BAC11480)"
FT /evidence="ECO:0000305"
FT CONFLICT 1067
FT /note="G -> V (in Ref. 2; AAQ88513)"
FT /evidence="ECO:0000305"
FT CONFLICT 1083
FT /note="D -> G (in Ref. 3; BAG37083)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1204 AA; 132888 MW; 7E883F4566276CE7 CRC64;
MYVTMMMTDQ IPLELPPLLN GEVAMMPHLV NGDAAQQVIL VQVNPGETFT IRAEDGTLQC
IQGPAEVPMM SPNGSIPPIH VPPGYISQVI EDSTGVRRVV VTPQSPECYP PSYPSAMSPT
HHLPPYLTHH PHFIHNSHTA YYPPVTGPGD MPPQFFPQHH LPHTIYGEQE IIPFYGMSTY
ITREDQYSKP PHKKLKDRQI DRQNRLNSPP SSIYKSSCTT VYNGYGKGHS GGSGGGGSGS
GPGIKKTERR ARSSPKSNDS DLQEYELEVK RVQDILSGIE KPQVSNIQAR AVVLSWAPPV
GLSCGPHSGL SFPYSYEVAL SDKGRDGKYK IIYSGEELEC NLKDLRPATD YHVRVYAMYN
SVKGSCSEPV SFTTHSCAPE CPFPPKLAHR SKSSLTLQWK APIDNGSKIT NYLLEWDEGK
RNSGFRQCFF GSQKHCKLTK LCPAMGYTFR LAARNDIGTS GYSQEVVCYT LGNIPQMPSA
PRLVRAGITW VTLQWSKPEG CSPEEVITYT LEIQEDENDN LFHPKYTGED LTCTVKNLKR
STQYKFRLTA SNTEGKSCPS EVLVCTTSPD RPGPPTRPLV KGPVTSHGFS VKWDPPKDNG
GSEILKYLLE ITDGNSEANQ WEVAYSGSAT EYTFTHLKPG TLYKLRACCI STGGHSQCSE
SLPVRTLSIA PGQCRPPRVL GRPKHKEVHL EWDVPASESG CEVSEYSVEM TEPEDVASEV
YHGPELECTV GNLLPGTVYR FRVRALNDGG YGPYSDVSEI TTAAGPPGQC KAPCISCTPD
GCVLVGWESP DSSGADISEY RLEWGEDEES LELIYHGTDT RFEIRDLLPA AQYCCRLQAF
NQAGAGPYSE LVLCQTPASA PDPVSTLCVL EEEPLDAYPD SPSACLVLNW EEPCNNGSEI
LAYTIDLGDT SITVGNTTMH VMKDLLPETT YRIRIQAINE IGAGPFSQFI KAKTRPLPPL
PPRLECAAAG PQSLKLKWGD SNSKTHAAED IVYTLQLEDR NKRFISIYRG PSHTYKVQRL
TEFTCYSFRI QAASEAGEGP FSETYTFSTT KSVPPTIKAP RVTQLEGNSC EILWETVPSM
KGDPVNYILQ VLVGRESEYK QVYKGEEATF QISGLQTNTD YRFRVCACRR CLDTSQELSG
AFSPSAAFVL QRSEVMLTGD MGSLDDPKMK SMMPTDEQFA AIIVLGFATL SILFAFILQY
FLMK
