FNDC1_CAEEL
ID FNDC1_CAEEL Reviewed; 138 AA.
AC Q22252;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=FUN14 domain-containing protein fndc-1 {ECO:0000305};
GN Name=fndc-1 {ECO:0000303|PubMed:31233739, ECO:0000312|WormBase:T06D8.7};
GN ORFNames=T06D8.7 {ECO:0000312|WormBase:T06D8.7};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=31233739; DOI=10.1016/j.ydbio.2019.06.016;
RA Lim Y., Rubio-Pena K., Sobraske P.J., Molina P.A., Brookes P.S., Galy V.,
RA Nehrke K.;
RT "Fndc-1 contributes to paternal mitochondria elimination in C. elegans.";
RL Dev. Biol. 454:15-20(2019).
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=31153831; DOI=10.1016/j.ydbio.2019.05.015;
RA Molina P., Lim Y., Boyd L.;
RT "Ubiquitination is required for the initial removal of paternal organelles
RT in C. elegans.";
RL Dev. Biol. 453:168-179(2019).
CC -!- FUNCTION: Mitophagy receptor which plays a role in paternal
CC mitochondria degradation in embryos after the two-cell stage.
CC {ECO:0000269|PubMed:31153831, ECO:0000269|PubMed:31233739}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000305|PubMed:31233739}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Broadly expressed in somatic tissues
CC (PubMed:31233739). Expressed in the hermaphrodite spermatheca and male
CC gonad (PubMed:31233739). Expressed in spermatids, but not expressed in
CC oocytes (PubMed:31233739). {ECO:0000269|PubMed:31233739}.
CC -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR EMBL; BX284602; CAA88970.1; -; Genomic_DNA.
DR PIR; T24580; T24580.
DR RefSeq; NP_496404.1; NM_064003.5.
DR AlphaFoldDB; Q22252; -.
DR STRING; 6239.T06D8.7; -.
DR EPD; Q22252; -.
DR PaxDb; Q22252; -.
DR PeptideAtlas; Q22252; -.
DR EnsemblMetazoa; T06D8.7.1; T06D8.7.1; WBGene00011528.
DR GeneID; 174714; -.
DR KEGG; cel:CELE_T06D8.7; -.
DR UCSC; T06D8.7.1; c. elegans.
DR CTD; 174714; -.
DR WormBase; T06D8.7; CE02328; WBGene00011528; fndc-1.
DR eggNOG; KOG4099; Eukaryota.
DR GeneTree; ENSGT00940000174663; -.
DR HOGENOM; CLU_1807901_0_0_1; -.
DR InParanoid; Q22252; -.
DR OMA; IHKGYIT; -.
DR OrthoDB; 1431148at2759; -.
DR PhylomeDB; Q22252; -.
DR Reactome; R-CEL-8934903; Receptor Mediated Mitophagy.
DR PRO; PR:Q22252; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00011528; Expressed in embryo and 4 other tissues.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR GO; GO:0000423; P:mitophagy; IMP:UniProtKB.
DR InterPro; IPR007014; FUN14.
DR PANTHER; PTHR21346; PTHR21346; 1.
DR Pfam; PF04930; FUN14; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Glycoprotein; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..138
FT /note="FUN14 domain-containing protein fndc-1"
FT /id="PRO_0000448277"
FT TRANSMEM 37..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 138 AA; 14697 MW; 1FB458D8B4F1F705 CRC64;
MVDLSKNDGG SGKAGKGVSD AIDTVLYYVV DLKKQQPMVQ LGVGAGFGTV TGYFVTKGGR
LVAATVGISF LLAQFAIHKG YITLNESKIE RDMKNLHKSV MNKVSGKKVI NISDSFVSEY
RWILGGFAAG MLIGFSVA
