FNDC1_HUMAN
ID FNDC1_HUMAN Reviewed; 1894 AA.
AC Q4ZHG4; A6H8X2; B7ZBR4; B7ZBR5; B9EK49; Q5JPI0; Q5VU31; Q5VU32; Q5VXX4;
AC Q70CQ6; Q96JG1;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 4.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Fibronectin type III domain-containing protein 1;
DE AltName: Full=Activation-associated cDNA protein;
DE AltName: Full=Expressed in synovial lining protein;
DE Flags: Precursor;
GN Name=FNDC1; Synonyms=FNDC2, KIAA1866, MEL4B3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS 1479-THR--THR-1484 DEL
RP AND LYS-1504.
RX PubMed=9704633;
RX DOI=10.1002/1529-0131(199808)41:8<1356::aid-art4>3.0.co;2-x;
RA Seki T., Selby J., Haupl T., Winchester R.;
RT "Use of differential subtraction method to identify genes that characterize
RT the phenotype of cultured rheumatoid arthritis synoviocytes.";
RL Arthritis Rheum. 41:1356-1364(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORM 2), AND VARIANTS
RP GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND
RP LYS-1504.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORMS 1 AND 2), AND
RP VARIANTS ALA-438; GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280;
RP 1479-THR--THR-1484 DEL AND LYS-1504.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1196-1894 (ISOFORM 1), AND
RP VARIANTS PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND LYS-1504.
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1295-1894 (ISOFORM 1), INDUCTION BY TGFB1,
RP AND VARIANTS 1479-THR--THR-1484 DEL AND LYS-1504.
RX PubMed=16098131; DOI=10.1111/j.0906-6705.2005.00349.x;
RA Anderegg U., Breitschwerdt K., Koehler M.J., Sticherling M.,
RA Haustein U.-F., Simon J.C., Saalbach A.;
RT "MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta
RT and pro-inflammatory cytokines.";
RL Exp. Dermatol. 14:709-718(2005).
CC -!- FUNCTION: May be an activator of G protein signaling. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4ZHG4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4ZHG4-2; Sequence=VSP_024663;
CC -!- TISSUE SPECIFICITY: Almost absent from healthy skin; especially in
CC epidermal keratinocytes, skin fibroblasts or endothelial cells and is
CC barely detectable in benign melanocytic naevi. Expressed in the stroma
CC close to skin tumors, in the tumor cells themselves and in the
CC epidermis of psoriasis.
CC -!- INDUCTION: By TGFB1 present in the melanoma cell conditioned medium
CC (MCCM). {ECO:0000269|PubMed:16098131}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-53 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI46784.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI50608.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAY26234.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAE51894.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; DQ009660; AAY26234.1; ALT_INIT; mRNA.
DR EMBL; AL355492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB058769; BAB47495.2; -; mRNA.
DR EMBL; BC146783; AAI46784.1; ALT_INIT; mRNA.
DR EMBL; BC150607; AAI50608.1; ALT_INIT; mRNA.
DR EMBL; AL832410; CAI46178.2; -; mRNA.
DR EMBL; AJ586132; CAE51894.1; ALT_FRAME; mRNA.
DR CCDS; CCDS47512.1; -. [Q4ZHG4-1]
DR RefSeq; NP_115921.2; NM_032532.2. [Q4ZHG4-1]
DR AlphaFoldDB; Q4ZHG4; -.
DR SMR; Q4ZHG4; -.
DR BioGRID; 124154; 23.
DR STRING; 9606.ENSP00000297267; -.
DR GlyGen; Q4ZHG4; 3 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q4ZHG4; -.
DR PhosphoSitePlus; Q4ZHG4; -.
DR BioMuta; FNDC1; -.
DR DMDM; 298286926; -.
DR jPOST; Q4ZHG4; -.
DR MassIVE; Q4ZHG4; -.
DR PaxDb; Q4ZHG4; -.
DR PeptideAtlas; Q4ZHG4; -.
DR PRIDE; Q4ZHG4; -.
DR ProteomicsDB; 62382; -. [Q4ZHG4-1]
DR ProteomicsDB; 62383; -. [Q4ZHG4-2]
DR Antibodypedia; 50561; 45 antibodies from 9 providers.
DR DNASU; 84624; -.
DR Ensembl; ENST00000297267.14; ENSP00000297267.9; ENSG00000164694.17. [Q4ZHG4-1]
DR GeneID; 84624; -.
DR KEGG; hsa:84624; -.
DR MANE-Select; ENST00000297267.14; ENSP00000297267.9; NM_032532.3; NP_115921.2.
DR UCSC; uc010kjv.4; human. [Q4ZHG4-1]
DR CTD; 84624; -.
DR DisGeNET; 84624; -.
DR GeneCards; FNDC1; -.
DR HGNC; HGNC:21184; FNDC1.
DR HPA; ENSG00000164694; Tissue enhanced (gallbladder, thyroid gland).
DR MIM; 609991; gene.
DR neXtProt; NX_Q4ZHG4; -.
DR OpenTargets; ENSG00000164694; -.
DR PharmGKB; PA134906656; -.
DR VEuPathDB; HostDB:ENSG00000164694; -.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00530000063558; -.
DR HOGENOM; CLU_002998_0_0_1; -.
DR InParanoid; Q4ZHG4; -.
DR OMA; GTLEQHD; -.
DR OrthoDB; 46073at2759; -.
DR PhylomeDB; Q4ZHG4; -.
DR TreeFam; TF337588; -.
DR PathwayCommons; Q4ZHG4; -.
DR BioGRID-ORCS; 84624; 12 hits in 1061 CRISPR screens.
DR ChiTaRS; FNDC1; human.
DR GenomeRNAi; 84624; -.
DR Pharos; Q4ZHG4; Tbio.
DR PRO; PR:Q4ZHG4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q4ZHG4; protein.
DR Bgee; ENSG00000164694; Expressed in tendon of biceps brachii and 130 other tissues.
DR ExpressionAtlas; Q4ZHG4; baseline and differential.
DR Genevisible; Q4ZHG4; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; -; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 4.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; SSF49265; 3.
DR PROSITE; PS50853; FN3; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Phosphoprotein; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..1894
FT /note="Fibronectin type III domain-containing protein 1"
FT /id="PRO_0000284831"
FT DOMAIN 39..131
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 158..258
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 262..357
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 362..457
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1658..1752
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 455..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1014
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 717
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2Q0I9"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1661
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 394..457
FT /note="EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGP
FT HSKAFIVAMPTT -> A (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_024663"
FT VARIANT 438
FT /note="T -> A (in dbSNP:rs509648)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031826"
FT VARIANT 463
FT /note="E -> Q (in dbSNP:rs420137)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_031827"
FT VARIANT 1003
FT /note="Q -> E (in dbSNP:rs370434)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_031828"
FT VARIANT 1180
FT /note="D -> E (in dbSNP:rs420054)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_031829"
FT VARIANT 1261
FT /note="L -> P (in dbSNP:rs3003174)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_031830"
FT VARIANT 1280
FT /note="Q -> R (in dbSNP:rs2501176)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_031831"
FT VARIANT 1479..1484
FT /note="Missing (in dbSNP:rs3842694)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16098131,
FT ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:9704633"
FT /id="VAR_063225"
FT VARIANT 1504
FT /note="T -> K (in dbSNP:rs386360)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16098131,
FT ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:9704633"
FT /id="VAR_031832"
FT VARIANT 1574
FT /note="T -> A (in dbSNP:rs7763726)"
FT /id="VAR_031833"
FT CONFLICT 36
FT /note="S -> P (in Ref. 1; AAY26234)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="P -> S (in Ref. 4; AAI50608)"
FT /evidence="ECO:0000305"
FT CONFLICT 1295
FT /note="M -> K (in Ref. 6; CAE51894)"
FT /evidence="ECO:0000305"
FT CONFLICT 1487
FT /note="P -> S (in Ref. 6; CAE51894)"
FT /evidence="ECO:0000305"
FT CONFLICT 1685
FT /note="D -> N (in Ref. 6; CAE51894)"
FT /evidence="ECO:0000305"
FT CONFLICT 1894
FT /note="W -> G (in Ref. 6; CAE51894)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1894 AA; 205558 MW; 7A0A9D0445E511D8 CRC64;
MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD
PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS
RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP
RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR
SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR
YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT
TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKEYILSYA PALKPFGAKS LTYPGDTTSA
LVDGLQPGER YLFKIRATNR RGLGPHSKAF IVAMPTTSKA DVEQNTEDNG KPEKPEPSSP
SPRAPASSQH PSVPASPQGR NAKDLLLDLK NKILANGGAP RKPQLRAKKA EELDLQSTEI
TGEEELGSRE DSPMSPSDTQ DQKRTLRPPS RHGHSVVAPG RTAVRARMPA LPRREGVDKP
GFSLATQPRP GAPPSASASP AHHASTQGTS HRPSLPASLN DNDLVDSDED ERAVGSLHPK
GAFAQPRPAL SPSRQSPSSV LRDRSSVHPG AKPASPARRT PHSGAAEEDS SASAPPSRLS
PPHGGSSRLL PTQPHLSSPL SKGGKDGEDA PATNSNAPSR STMSSSVSSH LSSRTQVSEG
AEASDGESHG DGDREDGGRQ AEATAQTLRA RPASGHFHLL RHKPFAANGR SPSRFSIGRG
PRLQPSSSPQ STVPSRAHPR VPSHSDSHPK LSSGIHGDEE DEKPLPATVV NDHVPSSSRQ
PISRGWEDLR RSPQRGASLH RKEPIPENPK STGADTHPQG KYSSLASKAQ DVQQSTDADT
EGHSPKAQPG STDRHASPAR PPAARSQQHP SVPRRMTPGR APQQQPPPPV ATSQHHPGPQ
SRDAGRSPSQ PRLSLTQAGR PRPTSQGRSH SSSDPYTASS RGMLPTALQN QDEDAQGSYD
DDSTEVEAQD VRAPAHAARA KEAAASLPKH QQVESPTGAG AGGDHRSQRG HAASPARPSR
PGGPQSRARV PSRAAPGKSE PPSKRPLSSK SQQSVSAEDD EEEDAGFFKG GKEDLLSSSV
PKWPSSSTPR GGKDADGSLA KEEREPAIAL APRGGSLAPV KRPLPPPPGS SPRASHVPSR
LPPRSAATVS PVAGTHPWPQ YTTRAPPGHF STTPMLSLRQ RMMHARFRNP LSRQPARPSY
RQGYNGRPNV EGKVLPGSNG KPNGQRIING PQGTKWVVDL DRGLVLNAEG RYLQDSHGNP
LRIKLGGDGR TIVDLEGTPV VSPDGLPLFG QGRHGTPLAN AQDKPILSLG GKPLVGLEVI
KKTTHPPTTT MQPTTTTTPL PTTTTPRPTT ATTRRTTTTR RTTTRRPTTT VRTTTRTTTT
TTPTPTTPIP TCPPGTLERH DDDGNLIMSS NGIPECYAEE DEFSGLETDT AVPTEEAYVI
YDEDYEFETS RPPTTTEPST TATTPRVIPE EGAISSFPEE EFDLAGRKRF VAPYVTYLNK
DPSAPCSLTD ALDHFQVDSL DEIIPNDLKK SDLPPQHAPR NITVVAVEGC HSFVIVDWDK
ATPGDVVTGY LVYSASYEDF IRNKWSTQAS SVTHLPIENL KPNTRYYFKV QAQNPHGYGP
ISPSVSFVTE SDNPLLVVRP PGGEPIWIPF AFKHDPSYTD CHGRQYVKRT WYRKFVGVVL
CNSLRYKIYL SDNLKDTFYS IGDSWGRGED HCQFVDSHLD GRTGPQSYVE ALPTIQGYYR
QYRQEPVRFG NIGFGTPYYY VGWYECGVSI PGKW
