ID   FNDC4_BOVIN             Reviewed;         230 AA.
AC   A6QPL2;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Fibronectin type III domain-containing protein 4;
DE   AltName: Full=Fibronectin type III repeat-containing protein 1;
DE   Flags: Precursor;
GN   Name=FNDC4; Synonyms=FRCP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an anti-inflammatory factor in the intestine and
CC       colon. Binds to and acts on macrophages to down-regulate pro-
CC       inflammatory gene expression. Affects key macrophage functions,
CC       including phagocytosis, by down-regulating many key pathways for
CC       macrophage activation, partly via by STAT3 activation and signaling.
CC       May be required to dampen the immunological response in colitis.
CC       {ECO:0000250|UniProtKB:Q3TR08}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Secreted
CC       {ECO:0000250|UniProtKB:Q3TR08}. Note=The N-terminus is probably cleaved
CC       to release a secreted extracellular portion of the protein.
CC       {ECO:0000250|UniProtKB:Q3TR08}.
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DR   EMBL; BC149374; AAI49375.1; -; mRNA.
DR   RefSeq; NP_001095794.1; NM_001102324.1.
DR   AlphaFoldDB; A6QPL2; -.
DR   SMR; A6QPL2; -.
DR   STRING; 9913.ENSBTAP00000041854; -.
DR   PaxDb; A6QPL2; -.
DR   Ensembl; ENSBTAT00000044349; ENSBTAP00000041854; ENSBTAG00000018164.
DR   GeneID; 781806; -.
DR   KEGG; bta:781806; -.
DR   CTD; 64838; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018164; -.
DR   VGNC; VGNC:29064; FNDC4.
DR   eggNOG; ENOG502QQ99; Eukaryota.
DR   GeneTree; ENSGT00390000004923; -.
DR   InParanoid; A6QPL2; -.
DR   OMA; PMGARQK; -.
DR   OrthoDB; 1198350at2759; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000018164; Expressed in diaphragm and 105 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0071559; P:response to transforming growth factor beta; IEA:Ensembl.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF00041; fn3; 1.
DR   SMART; SM00060; FN3; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Secreted; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..40
FT                   /evidence="ECO:0000255"
FT   CHAIN           41..230
FT                   /note="Fibronectin type III domain-containing protein 4"
FT                   /id="PRO_0000355205"
FT   TOPO_DOM        41..163
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        185..230
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          43..136
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          118..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   230 AA;  24753 MW;  E93D468778F9EFC2 CRC64;
     MPGCLPADSV GTMASLMPLS PYLSPTVLLL VSCDLGFVRA DRPPSPVNVT VTHLRANSAT
     VSWDVPEGNI VIGYSISQQR QNGPGQRVIR EVNTTTRACA LWGLAEDSDY TVQVRSIGLR
     GESPPGPRVH FRTLKGSDRL PSNSSSPGDI TVEGLDGERP LQTGEVVIIV VVLLMWAAVI
     GLFCRQYDII KDNDSNNNPK EKGKGPEQSP QGRPVGTRQK KSPSINTIDV