FNDC5_DANRE
ID FNDC5_DANRE Reviewed; 207 AA.
AC Q1L867;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Fibronectin type III domain-containing protein 5;
DE Contains:
DE RecName: Full=Irisin;
DE Flags: Precursor;
GN Name=fndc5; ORFNames=si:dkey-264p5.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: [Irisin]: May mediate beneficial effects of muscular
CC exercise.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Irisin]: Secreted {ECO:0000250}. Note=Detected
CC in the blood of individuals subjected to endurance exercise.
CC {ECO:0000250}.
CC -!- PTM: N-Glycosylated. {ECO:0000250}.
CC -!- PTM: The extracellular domain is cleaved and released from the cell
CC membrane. {ECO:0000250}.
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DR EMBL; CR954168; CAK10901.1; -; Genomic_DNA.
DR RefSeq; NP_001037802.1; NM_001044337.1.
DR RefSeq; XP_005159703.1; XM_005159646.3.
DR AlphaFoldDB; Q1L867; -.
DR SMR; Q1L867; -.
DR STRING; 7955.ENSDARP00000101528; -.
DR PaxDb; Q1L867; -.
DR Ensembl; ENSDART00000052108; ENSDARP00000052107; ENSDARG00000035895.
DR GeneID; 555635; -.
DR KEGG; dre:555635; -.
DR CTD; 555635; -.
DR ZFIN; ZDB-GENE-060503-916; fndc5b.
DR eggNOG; ENOG502QQCU; Eukaryota.
DR GeneTree; ENSGT00390000004923; -.
DR HOGENOM; CLU_089166_1_0_1; -.
DR InParanoid; Q1L867; -.
DR OMA; TWEIFEG; -.
DR OrthoDB; 1198350at2759; -.
DR PhylomeDB; Q1L867; -.
DR TreeFam; TF325415; -.
DR PRO; PR:Q1L867; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000035895; Expressed in brain and 10 other tissues.
DR ExpressionAtlas; Q1L867; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR032073; FNDC5_C.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF16066; DUF4808; 1.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Hormone; Membrane; Peroxisome;
KW Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..207
FT /note="Fibronectin type III domain-containing protein 5"
FT /id="PRO_0000328974"
FT CHAIN 27..138
FT /note="Irisin"
FT /id="PRO_0000415856"
FT TOPO_DOM 27..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..207
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..122
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 178..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 205..207
FT /note="Microbody targeting signal"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 207 AA; 22756 MW; 00CEF2949D2720E1 CRC64;
MWGIKGSFAV LLLLFLAYIF ASSVNADSLS APLNVTIKAL EGNSAIVTWD ILEGDPVIGF
AITQQKKDVR MLRFIQEVNT TTRSCALWDL EEDTEYIVHV QSISMSGTSP PSEPVLFRTP
KESEKLASKS PDEVTMEEVG QAAQLRAGEL IIIVVVLVMW AGVIALFCRQ YDIIKDNEPN
NNKDKAKNSS ECSTPEHPTG GLLRSKV
