ALAE_ESCF3
ID ALAE_ESCF3 Reviewed; 154 AA.
AC B7LVR8;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 2.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=L-alanine exporter AlaE {ECO:0000255|HAMAP-Rule:MF_00914};
GN Name=alaE {ECO:0000255|HAMAP-Rule:MF_00914}; OrderedLocusNames=EFER_0402;
OS Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 / JCM
RC 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Exports L-alanine. {ECO:0000255|HAMAP-Rule:MF_00914}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00914}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00914}.
CC -!- SIMILARITY: Belongs to the AlaE exporter family. {ECO:0000255|HAMAP-
CC Rule:MF_00914}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAQ87963.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CU928158; CAQ87963.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; B7LVR8; -.
DR EnsemblBacteria; CAQ87963; CAQ87963; EFER_0402.
DR KEGG; efe:EFER_0402; -.
DR HOGENOM; CLU_126493_0_0_6; -.
DR Proteomes; UP000000745; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0034639; F:L-amino acid efflux transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032973; P:amino acid export across plasma membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00914; L_Ala_exporter; 1.
DR InterPro; IPR010574; Ala_export_AlaE.
DR Pfam; PF06610; AlaE; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..154
FT /note="L-alanine exporter AlaE"
FT /id="PRO_0000415623"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
SQ SEQUENCE 154 AA; 17603 MW; 5A32FA49195E2147 CRC64;
MESHTMLSAQ SRWRNAMADT FAMVVYCTVV NMLIEIFLSG MSFEQSLSSR LVAIPVNILI
ACPYGIYRDF FMRQARKMNN KGWTKTIADI LAYVTFQSPV YAAILWVIGA DWHQIVAAVS
SNMVISMMMG AVYGYFLDYC RRLFKVTSYQ QLKA