FNDC7_HUMAN
ID FNDC7_HUMAN Reviewed; 733 AA.
AC Q5VTL7; A1L468; E9PAZ5; Q6PF16; Q8NA51;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Fibronectin type III domain-containing protein 7;
DE Flags: Precursor;
GN Name=FNDC7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 210-733, AND VARIANT ALA-353.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 226-733.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57762.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI30422.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC04077.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL591719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057762; AAH57762.1; ALT_INIT; mRNA.
DR EMBL; BC130421; AAI30422.1; ALT_INIT; mRNA.
DR EMBL; AK093157; BAC04077.1; ALT_INIT; mRNA.
DR CCDS; CCDS44185.1; -.
DR RefSeq; NP_001138409.1; NM_001144937.1.
DR AlphaFoldDB; Q5VTL7; -.
DR SMR; Q5VTL7; -.
DR BioGRID; 127866; 2.
DR STRING; 9606.ENSP00000359034; -.
DR GlyGen; Q5VTL7; 2 sites.
DR iPTMnet; Q5VTL7; -.
DR PhosphoSitePlus; Q5VTL7; -.
DR BioMuta; FNDC7; -.
DR DMDM; 380865465; -.
DR MassIVE; Q5VTL7; -.
DR PaxDb; Q5VTL7; -.
DR PeptideAtlas; Q5VTL7; -.
DR PRIDE; Q5VTL7; -.
DR ProteomicsDB; 65334; -.
DR Antibodypedia; 33735; 120 antibodies from 19 providers.
DR DNASU; 163479; -.
DR Ensembl; ENST00000370017.9; ENSP00000359034.3; ENSG00000143107.10.
DR GeneID; 163479; -.
DR KEGG; hsa:163479; -.
DR MANE-Select; ENST00000370017.9; ENSP00000359034.3; NM_001144937.3; NP_001138409.1.
DR UCSC; uc001dvx.4; human.
DR CTD; 163479; -.
DR GeneCards; FNDC7; -.
DR HGNC; HGNC:26668; FNDC7.
DR HPA; ENSG00000143107; Tissue enhanced (brain, testis).
DR neXtProt; NX_Q5VTL7; -.
DR OpenTargets; ENSG00000143107; -.
DR PharmGKB; PA142671756; -.
DR VEuPathDB; HostDB:ENSG00000143107; -.
DR eggNOG; ENOG502QTU0; Eukaryota.
DR GeneTree; ENSGT00390000004674; -.
DR InParanoid; Q5VTL7; -.
DR OMA; GFNVVEC; -.
DR OrthoDB; 190531at2759; -.
DR TreeFam; TF331331; -.
DR PathwayCommons; Q5VTL7; -.
DR BioGRID-ORCS; 163479; 8 hits in 1056 CRISPR screens.
DR GenomeRNAi; 163479; -.
DR Pharos; Q5VTL7; Tdark.
DR PRO; PR:Q5VTL7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VTL7; protein.
DR Bgee; ENSG00000143107; Expressed in left testis and 18 other tissues.
DR ExpressionAtlas; Q5VTL7; baseline and differential.
DR Genevisible; Q5VTL7; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SMART; SM00060; FN3; 7.
DR SUPFAM; SSF49265; SSF49265; 4.
DR PROSITE; PS50853; FN3; 7.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..733
FT /note="Fibronectin type III domain-containing protein 7"
FT /id="PRO_0000328880"
FT DOMAIN 28..115
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 116..202
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 203..288
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 289..373
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 374..459
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 460..544
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 545..632
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 631..715
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 309
FT /note="S -> N (in dbSNP:rs11582005)"
FT /id="VAR_042570"
FT VARIANT 353
FT /note="V -> A (in dbSNP:rs4494160)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_042571"
FT VARIANT 367
FT /note="N -> S (in dbSNP:rs3006870)"
FT /id="VAR_042572"
FT VARIANT 685
FT /note="P -> L (in dbSNP:rs1277017)"
FT /id="VAR_042573"
FT CONFLICT 210
FT /note="S -> F (in Ref. 2; AAH57762)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="R -> L (in Ref. 2; AAH57762)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 733 AA; 78236 MW; 5D0E0EDBEAF2C630 CRC64;
MAGGRETCLP LIGFILICLK MVASAKSAPE IPTIDQAYSK LSNSITVEWA TVPGATSYLL
TAEDGDTVIE TTVANSPGTV TGLKAATWYE ITIRSISAAG RSQASPPKQA KTVLAAPILE
VSSPSSDSIL VQWEAVYMAI AFSVSIMRAN GLGSIWKENT TNTSLTFTSL EAGTLYTIKA
YAWNANRIPG DDSTCNQRTS PRAPANIQVS FDSGALKASF SWARAEGAFN YTVMALSDSS
ELTCSTTFSS CTISSLQCGT EYLISVLASN DAGSSKSSSA MTLKTVACAP GRVTIQEDPP
GHLSVAWSSV DLGDYYVVFV KSDDGLEVHC NTSLTQCNFL SECGFTYFIS VFVYNKAGQS
PLGDIFNYTT APCCPSDINP VLVSSDRVEI VWSPVRGAEL YETKAVDGYN MVECNDTTPA
CTLSALECDT KYNITVYSFN EVRGSNMSCT PQFITTAPCS PEIKNVSRDA FSMINVHWRS
TNDDATYTVT AQGEKGLYQC SSTGESCTMR GLPCGSVFSV TAVAETQAGR SLPSYSVPLE
TVPCCPTGLT VTQITQSVIN VSWTIGRVAQ THVAVLESHT GQSKCHTHQN HCLLGCITCG
INYTVTLKAI SATGLTADCS YQSYFSGACC PLGVKLYRLG PNGIRIYWQA SRGSANYSTD
LYGSKGIFTC TPSAGLSFCD VTEIPCGDVY TVMVSPVAKT GLKLTFCPKK IYSVTCSGST
LGMVIYRGKR NEE
