FNDC7_MOUSE
ID FNDC7_MOUSE Reviewed; 737 AA.
AC A2AED3; A2AED1; A2AED2; Q14DI4; Q14DS1; Q3TNR1; Q8BW61; Q8BW83;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Fibronectin type III domain-containing protein 7;
DE Flags: Precursor;
GN Name=Fndc7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A2AED3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2AED3-3; Sequence=VSP_024610, VSP_024612, VSP_024613;
CC Name=3;
CC IsoId=A2AED3-4; Sequence=VSP_024611;
CC -!- SEQUENCE CAUTION:
CC Sequence=BC113188; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAM20604.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM20605.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK053989; BAC35609.1; -; mRNA.
DR EMBL; AK054241; BAC35702.2; -; mRNA.
DR EMBL; AK165075; BAE38027.1; -; mRNA.
DR EMBL; AL671894; CAM20604.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL671894; CAM20605.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL671894; CAM20606.1; -; Genomic_DNA.
DR EMBL; BC111898; AAI11899.1; -; mRNA.
DR EMBL; BC113188; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS17769.1; -. [A2AED3-1]
DR CCDS; CCDS51050.1; -. [A2AED3-4]
DR RefSeq; NP_001159437.1; NM_001165965.1. [A2AED3-4]
DR RefSeq; NP_796065.2; NM_177091.5. [A2AED3-1]
DR AlphaFoldDB; A2AED3; -.
DR SMR; A2AED3; -.
DR STRING; 10090.ENSMUSP00000099680; -.
DR GlyGen; A2AED3; 2 sites.
DR iPTMnet; A2AED3; -.
DR PhosphoSitePlus; A2AED3; -.
DR PaxDb; A2AED3; -.
DR PRIDE; A2AED3; -.
DR ProteomicsDB; 271779; -. [A2AED3-1]
DR ProteomicsDB; 271780; -. [A2AED3-3]
DR ProteomicsDB; 271781; -. [A2AED3-4]
DR Antibodypedia; 33735; 120 antibodies from 19 providers.
DR Ensembl; ENSMUST00000053065; ENSMUSP00000051172; ENSMUSG00000045326. [A2AED3-4]
DR Ensembl; ENSMUST00000102620; ENSMUSP00000099680; ENSMUSG00000045326. [A2AED3-1]
DR GeneID; 320181; -.
DR KEGG; mmu:320181; -.
DR UCSC; uc008qzv.2; mouse. [A2AED3-1]
DR UCSC; uc008qzw.1; mouse. [A2AED3-3]
DR UCSC; uc012cwg.1; mouse. [A2AED3-4]
DR CTD; 163479; -.
DR MGI; MGI:2443535; Fndc7.
DR VEuPathDB; HostDB:ENSMUSG00000045326; -.
DR eggNOG; ENOG502QTU0; Eukaryota.
DR GeneTree; ENSGT00390000004674; -.
DR HOGENOM; CLU_024430_0_0_1; -.
DR InParanoid; A2AED3; -.
DR OMA; GFNVVEC; -.
DR OrthoDB; 190531at2759; -.
DR PhylomeDB; A2AED3; -.
DR TreeFam; TF331331; -.
DR BioGRID-ORCS; 320181; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Fndc7; mouse.
DR PRO; PR:A2AED3; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; A2AED3; protein.
DR Bgee; ENSMUSG00000045326; Expressed in vestibular epithelium and 27 other tissues.
DR ExpressionAtlas; A2AED3; baseline and differential.
DR Genevisible; A2AED3; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SMART; SM00060; FN3; 6.
DR SUPFAM; SSF49265; SSF49265; 4.
DR PROSITE; PS50853; FN3; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..737
FT /note="Fibronectin type III domain-containing protein 7"
FT /id="PRO_0000284678"
FT DOMAIN 28..115
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 116..203
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 204..288
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 289..373
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 374..459
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 460..544
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 545..633
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 631..715
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..137
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024610"
FT VAR_SEQ 200..286
FT /note="SPRAPANIQVFFDSGALKASVSWTPTEGAFNYTVVASSDSSQRSCSTTLSSC
FT SISSLQCGTEYLISVSANNDAGSSKSCSAPTLKTV -> I (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024611"
FT VAR_SEQ 457..461
FT /note="APCSP -> GMVLL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024612"
FT VAR_SEQ 462..737
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024613"
FT CONFLICT 28
FT /note="A -> G (in Ref. 3; BC113188)"
FT /evidence="ECO:0000305"
FT CONFLICT 254
FT /note="S -> T (in Ref. 1; BAC35609)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="S -> F (in Ref. 3; BC113188)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="V -> I (in Ref. 3; BC113188)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 737 AA; 78141 MW; 91C096C252D5B239 CRC64;
MAGRPEKCFS LIRFTLLCLK MVISSKTAPE IPTIDQAYSK ISNSITVEWT TVPGATSYLL
TAEDGNTIIE TTVANSPGTV TGLKAATLYQ ITIRSISASG QSQASSPKQA KTVLAAPVLE
VSSPSPDSIL VSWDAVYMAI GFSVSVMRAN GLGRIWKENT TNTSLTFSSL DAGTLYTIKA
YAWNANGIPG DDSTRNQRTS PRAPANIQVF FDSGALKASV SWTPTEGAFN YTVVASSDSS
QRSCSTTLSS CSISSLQCGT EYLISVSANN DAGSSKSCSA PTLKTVACAP GRVMIQEEPP
GHLSVAWSNV ELGDYYVAFV KSDDGLEVHC NTSLTQCNFL SECGFTYFIS VFAYNKAGQS
PLGDVFNYTT APCCPNDISP VLVSSDRVEI AWSPVRGAEL YETKAIAGYS IVECNDTAPA
CTLSALDCDT KYNVTVYSFS EVRGSNLSCS SHFITTAPCS PEIKNISKDA FSMINVHWRS
TNEGATYTVT AQGKKGLFQC SSTGETCRMG GLPCGSMFSV TAVAETQAGK SLPSYSVPLE
TVPCCPAGLT AAQVTQSIIN VSWTAGAVAQ TYAAVLESYI GQSKCHTHQN HCLLGCITCG
INYTVALKAI SSTGLTADCA YQSYSSSVCC PLGVKLYRLG PNGIRIYWRA SRGAANYSTD
LYGSKGIFTC APHAGLSFCD ITNIPCGDVY TVMVSPVAET GLKLTFCPKK IYSVTCSGST
LGMVIYRGKR NDTASPR
