FNDC8_HUMAN
ID FNDC8_HUMAN Reviewed; 324 AA.
AC Q8TC99; B2R9G6; Q9UFC2;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Fibronectin type III domain-containing protein 8;
GN Name=FNDC8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-36.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TC99; Q15013: MAD2L1BP; NbExp=3; IntAct=EBI-12903902, EBI-712181;
CC Q8TC99; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-12903902, EBI-348259;
CC Q8TC99; Q92569: PIK3R3; NbExp=3; IntAct=EBI-12903902, EBI-79893;
CC Q8TC99; Q147U7: SMCO1; NbExp=3; IntAct=EBI-12903902, EBI-11735944;
CC Q8TC99; P36508: ZNF76; NbExp=3; IntAct=EBI-12903902, EBI-7254550;
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DR EMBL; AK313775; BAG36513.1; -; mRNA.
DR EMBL; AL133054; CAB61380.1; -; mRNA.
DR EMBL; BC024002; AAH24002.1; -; mRNA.
DR CCDS; CCDS11290.1; -.
DR PIR; T42656; T42656.
DR RefSeq; NP_060029.1; NM_017559.2.
DR AlphaFoldDB; Q8TC99; -.
DR BioGRID; 120129; 16.
DR IntAct; Q8TC99; 5.
DR GlyGen; Q8TC99; 1 site, 4 N-linked glycans (1 site).
DR iPTMnet; Q8TC99; -.
DR PhosphoSitePlus; Q8TC99; -.
DR BioMuta; FNDC8; -.
DR DMDM; 145558918; -.
DR MassIVE; Q8TC99; -.
DR PaxDb; Q8TC99; -.
DR PeptideAtlas; Q8TC99; -.
DR PRIDE; Q8TC99; -.
DR ProteomicsDB; 74104; -.
DR Antibodypedia; 15564; 178 antibodies from 19 providers.
DR DNASU; 54752; -.
DR Ensembl; ENST00000158009.6; ENSP00000158009.4; ENSG00000073598.6.
DR GeneID; 54752; -.
DR KEGG; hsa:54752; -.
DR MANE-Select; ENST00000158009.6; ENSP00000158009.4; NM_017559.4; NP_060029.1.
DR UCSC; uc002hix.4; human.
DR CTD; 54752; -.
DR GeneCards; FNDC8; -.
DR HGNC; HGNC:25286; FNDC8.
DR HPA; ENSG00000073598; Tissue enriched (testis).
DR neXtProt; NX_Q8TC99; -.
DR OpenTargets; ENSG00000073598; -.
DR PharmGKB; PA142671757; -.
DR VEuPathDB; HostDB:ENSG00000073598; -.
DR eggNOG; ENOG502STU7; Eukaryota.
DR GeneTree; ENSGT00390000006458; -.
DR HOGENOM; CLU_075088_0_0_1; -.
DR InParanoid; Q8TC99; -.
DR OMA; APFICEH; -.
DR OrthoDB; 971665at2759; -.
DR PhylomeDB; Q8TC99; -.
DR TreeFam; TF338149; -.
DR PathwayCommons; Q8TC99; -.
DR SignaLink; Q8TC99; -.
DR BioGRID-ORCS; 54752; 17 hits in 1063 CRISPR screens.
DR GenomeRNAi; 54752; -.
DR Pharos; Q8TC99; Tdark.
DR PRO; PR:Q8TC99; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8TC99; protein.
DR Bgee; ENSG00000073598; Expressed in left testis and 45 other tissues.
DR Genevisible; Q8TC99; HS.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..324
FT /note="Fibronectin type III domain-containing protein 8"
FT /id="PRO_0000284530"
FT DOMAIN 179..280
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT VARIANT 36
FT /note="S -> P (in dbSNP:rs1871892)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031770"
FT VARIANT 127
FT /note="A -> T (in dbSNP:rs12952106)"
FT /id="VAR_050999"
SQ SEQUENCE 324 AA; 35921 MW; FB08649C5CADE086 CRC64;
MASEALHQVG DGEEAVLKKE NFNMMNALDQ LPKPFSNPKS MNRTVTTKGL PLASKGNLVN
FLEDDTINLL KPLPVEDSDC SSDETSISAF SSTLLNPIKL AVTQPNSSFF AGMLEGELNK
LSFSPMAKNA ENEDLALGPC PCPSKSQMAT RGLLDLDNPE LETETSSTHS ESSVVVDLPD
TPFIFEHTVN NSTAVISWTY ALGKQPVSFY QLLLQEVAKT QENELPEAKN RPWIFNKILG
TTVKLMELKP NTCYCLSVRA ANTAGVGKWC KPYKFATLAT DFSSFPENYP IQITVRRKEP
RQKIVSIGPE EMRRLEDLEY LFPC
