FNDC8_MOUSE
ID FNDC8_MOUSE Reviewed; 321 AA.
AC Q9D2H8; Q8BUG1;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Fibronectin type III domain-containing protein 8;
GN Name=Fndc8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D2H8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D2H8-2; Sequence=VSP_024559;
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DR EMBL; AK019639; BAB31821.1; -; mRNA.
DR EMBL; AK085347; BAC39428.1; -; mRNA.
DR EMBL; AL603745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120835; AAI20836.1; -; mRNA.
DR CCDS; CCDS25151.1; -. [Q9D2H8-1]
DR RefSeq; NP_084500.1; NM_030224.1. [Q9D2H8-1]
DR AlphaFoldDB; Q9D2H8; -.
DR iPTMnet; Q9D2H8; -.
DR PhosphoSitePlus; Q9D2H8; -.
DR MaxQB; Q9D2H8; -.
DR PaxDb; Q9D2H8; -.
DR PRIDE; Q9D2H8; -.
DR ProteomicsDB; 267608; -. [Q9D2H8-1]
DR ProteomicsDB; 267609; -. [Q9D2H8-2]
DR Antibodypedia; 15564; 178 antibodies from 19 providers.
DR Ensembl; ENSMUST00000018988; ENSMUSP00000018988; ENSMUSG00000018844. [Q9D2H8-1]
DR GeneID; 78919; -.
DR KEGG; mmu:78919; -.
DR UCSC; uc007knr.1; mouse. [Q9D2H8-1]
DR CTD; 54752; -.
DR MGI; MGI:1926169; Fndc8.
DR VEuPathDB; HostDB:ENSMUSG00000018844; -.
DR eggNOG; ENOG502STU7; Eukaryota.
DR GeneTree; ENSGT00390000006458; -.
DR HOGENOM; CLU_075088_0_0_1; -.
DR InParanoid; Q9D2H8; -.
DR OMA; APFICEH; -.
DR PhylomeDB; Q9D2H8; -.
DR TreeFam; TF338149; -.
DR BioGRID-ORCS; 78919; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q9D2H8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D2H8; protein.
DR Bgee; ENSMUSG00000018844; Expressed in seminiferous tubule of testis and 29 other tissues.
DR ExpressionAtlas; Q9D2H8; baseline and differential.
DR Genevisible; Q9D2H8; MM.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..321
FT /note="Fibronectin type III domain-containing protein 8"
FT /id="PRO_0000284532"
FT DOMAIN 175..277
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024559"
FT CONFLICT 228
FT /note="R -> P (in Ref. 1; BAC39428)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 35619 MW; A732F9DDF9F00E26 CRC64;
MATVFCKVGG GEEAVPKKEA LNVINVIDQL PKPCPNPKFI NRSMATKGLL LPSRRSLASF
SEEENTDVMM HMPVEDSEYS SDDTSMSPIP STLMNPIKMA VTQPNSSFFA GILEGELNKL
SLASVVKNTE KDNLAICPRS SKSQIATRGL LDLDNPALDT DTSSTRSESS VVLDVPEVPF
ICEHTVGDST AVISWTYAAG KQQVSFYQVL LQEATKPADK DTPKIKTRPW IFNKILGTTV
KLMELKSNTS YCLTVRAANT AGVGKWCKPY KFATVSTDFN SFPETNPIQV TVQRKQPHRR
TVSMTMEEMR RLEDLEYLYP Y
