FNDC9_HUMAN
ID FNDC9_HUMAN Reviewed; 224 AA.
AC Q8TBE3; A8K0Y6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Fibronectin type III domain-containing protein 9;
GN Name=FNDC9; Synonyms=C5orf40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-50.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TBE3; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-12142257, EBI-10827839;
CC Q8TBE3; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-12142257, EBI-11522760;
CC Q8TBE3; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-12142257, EBI-11957045;
CC Q8TBE3; Q16853: AOC3; NbExp=3; IntAct=EBI-12142257, EBI-3921628;
CC Q8TBE3; P29972: AQP1; NbExp=3; IntAct=EBI-12142257, EBI-745213;
CC Q8TBE3; P07306: ASGR1; NbExp=3; IntAct=EBI-12142257, EBI-1172335;
CC Q8TBE3; P27449: ATP6V0C; NbExp=3; IntAct=EBI-12142257, EBI-721179;
CC Q8TBE3; P54253: ATXN1; NbExp=3; IntAct=EBI-12142257, EBI-930964;
CC Q8TBE3; O95393: BMP10; NbExp=3; IntAct=EBI-12142257, EBI-3922513;
CC Q8TBE3; Q86Z23: C1QL4; NbExp=3; IntAct=EBI-12142257, EBI-12062109;
CC Q8TBE3; Q06432: CACNG1; NbExp=3; IntAct=EBI-12142257, EBI-9686780;
CC Q8TBE3; Q8IX05: CD302; NbExp=3; IntAct=EBI-12142257, EBI-14259393;
CC Q8TBE3; O95832: CLDN1; NbExp=3; IntAct=EBI-12142257, EBI-723889;
CC Q8TBE3; O75508: CLDN11; NbExp=3; IntAct=EBI-12142257, EBI-12820543;
CC Q8TBE3; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-12142257, EBI-12256978;
CC Q8TBE3; Q8NC01: CLEC1A; NbExp=3; IntAct=EBI-12142257, EBI-11996768;
CC Q8TBE3; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-12142257, EBI-11749983;
CC Q8TBE3; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-12142257, EBI-11989440;
CC Q8TBE3; Q9NWW5: CLN6; NbExp=3; IntAct=EBI-12142257, EBI-6165897;
CC Q8TBE3; A0PK11: CLRN2; NbExp=3; IntAct=EBI-12142257, EBI-12813623;
CC Q8TBE3; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-12142257, EBI-11522780;
CC Q8TBE3; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-12142257, EBI-12208021;
CC Q8TBE3; Q4VAQ0: COL8A2; NbExp=3; IntAct=EBI-12142257, EBI-10241815;
CC Q8TBE3; Q07325: CXCL9; NbExp=3; IntAct=EBI-12142257, EBI-3911467;
CC Q8TBE3; O43169: CYB5B; NbExp=3; IntAct=EBI-12142257, EBI-1058710;
CC Q8TBE3; Q7Z7B7: DEFB132; NbExp=3; IntAct=EBI-12142257, EBI-17250048;
CC Q8TBE3; Q9UPQ8: DOLK; NbExp=3; IntAct=EBI-12142257, EBI-8645574;
CC Q8TBE3; P56851: EDDM3B; NbExp=3; IntAct=EBI-12142257, EBI-10215665;
CC Q8TBE3; P54852: EMP3; NbExp=3; IntAct=EBI-12142257, EBI-3907816;
CC Q8TBE3; O75355-2: ENTPD3; NbExp=3; IntAct=EBI-12142257, EBI-12279764;
CC Q8TBE3; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-12142257, EBI-10976398;
CC Q8TBE3; Q92935: EXTL1; NbExp=3; IntAct=EBI-12142257, EBI-1760167;
CC Q8TBE3; Q92520: FAM3C; NbExp=3; IntAct=EBI-12142257, EBI-2876774;
CC Q8TBE3; Q8N3T1: GALNT15; NbExp=3; IntAct=EBI-12142257, EBI-3925203;
CC Q8TBE3; Q8N0V5-3: GCNT2; NbExp=3; IntAct=EBI-12142257, EBI-17248158;
CC Q8TBE3; Q9HCP6: HHATL; NbExp=3; IntAct=EBI-12142257, EBI-5916693;
CC Q8TBE3; P24593: IGFBP5; NbExp=3; IntAct=EBI-12142257, EBI-720480;
CC Q8TBE3; O43736: ITM2A; NbExp=3; IntAct=EBI-12142257, EBI-2431769;
CC Q8TBE3; Q9NQX7-3: ITM2C; NbExp=3; IntAct=EBI-12142257, EBI-12811565;
CC Q8TBE3; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-12142257, EBI-10266796;
CC Q8TBE3; Q53RY4: KRTCAP3; NbExp=3; IntAct=EBI-12142257, EBI-12383540;
CC Q8TBE3; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12142257, EBI-2820517;
CC Q8TBE3; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-12142257, EBI-12033434;
CC Q8TBE3; P21145: MAL; NbExp=3; IntAct=EBI-12142257, EBI-3932027;
CC Q8TBE3; Q13021: MALL; NbExp=3; IntAct=EBI-12142257, EBI-750078;
CC Q8TBE3; O75425: MOSPD3; NbExp=3; IntAct=EBI-12142257, EBI-12179105;
CC Q8TBE3; Q96S97: MYADM; NbExp=3; IntAct=EBI-12142257, EBI-13301517;
CC Q8TBE3; Q92982: NINJ1; NbExp=3; IntAct=EBI-12142257, EBI-2802124;
CC Q8TBE3; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-12142257, EBI-10317425;
CC Q8TBE3; Q16617: NKG7; NbExp=3; IntAct=EBI-12142257, EBI-3919611;
CC Q8TBE3; P42857: NSG1; NbExp=3; IntAct=EBI-12142257, EBI-6380741;
CC Q8TBE3; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-12142257, EBI-2804156;
CC Q8TBE3; P0DJD7: PGA4; NbExp=3; IntAct=EBI-12142257, EBI-12957629;
CC Q8TBE3; Q9UHJ9-5: PGAP2; NbExp=3; IntAct=EBI-12142257, EBI-12092917;
CC Q8TBE3; Q9Y342: PLLP; NbExp=3; IntAct=EBI-12142257, EBI-3919291;
CC Q8TBE3; P26678: PLN; NbExp=3; IntAct=EBI-12142257, EBI-692836;
CC Q8TBE3; P60201-2: PLP1; NbExp=3; IntAct=EBI-12142257, EBI-12188331;
CC Q8TBE3; Q04941: PLP2; NbExp=3; IntAct=EBI-12142257, EBI-608347;
CC Q8TBE3; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-12142257, EBI-11721828;
CC Q8TBE3; Q59EV6: PPGB; NbExp=3; IntAct=EBI-12142257, EBI-14210385;
CC Q8TBE3; Q8NFJ6: PROKR2; NbExp=3; IntAct=EBI-12142257, EBI-12902928;
CC Q8TBE3; Q9NS64: RPRM; NbExp=3; IntAct=EBI-12142257, EBI-1052363;
CC Q8TBE3; O75396: SEC22B; NbExp=3; IntAct=EBI-12142257, EBI-1058865;
CC Q8TBE3; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-12142257, EBI-749270;
CC Q8TBE3; P11686: SFTPC; NbExp=3; IntAct=EBI-12142257, EBI-10197617;
CC Q8TBE3; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-12142257, EBI-10262251;
CC Q8TBE3; P78382: SLC35A1; NbExp=3; IntAct=EBI-12142257, EBI-12870360;
CC Q8TBE3; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-12142257, EBI-10290130;
CC Q8TBE3; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-12142257, EBI-12188413;
CC Q8TBE3; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-12142257, EBI-741850;
CC Q8TBE3; Q96JF0-2: ST6GAL2; NbExp=3; IntAct=EBI-12142257, EBI-12908338;
CC Q8TBE3; Q9UNK0: STX8; NbExp=3; IntAct=EBI-12142257, EBI-727240;
CC Q8TBE3; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-12142257, EBI-8644968;
CC Q8TBE3; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-12142257, EBI-2844246;
CC Q8TBE3; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-12142257, EBI-10255122;
CC Q8TBE3; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-12142257, EBI-11956809;
CC Q8TBE3; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-12142257, EBI-2852148;
CC Q8TBE3; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-12142257, EBI-8649725;
CC Q8TBE3; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-12142257, EBI-12015604;
CC Q8TBE3; Q9NRS4: TMPRSS4; NbExp=3; IntAct=EBI-12142257, EBI-10313040;
CC Q8TBE3; P01375: TNF; NbExp=3; IntAct=EBI-12142257, EBI-359977;
CC Q8TBE3; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-12142257, EBI-16746122;
CC Q8TBE3; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-12142257, EBI-12195249;
CC Q8TBE3; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-12142257, EBI-10243654;
CC Q8TBE3; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12142257, EBI-11988865;
CC Q8TBE3; Q9GZX9: TWSG1; NbExp=3; IntAct=EBI-12142257, EBI-10304067;
CC Q8TBE3; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-12142257, EBI-2819725;
CC Q8TBE3; O75841: UPK1B; NbExp=3; IntAct=EBI-12142257, EBI-12237619;
CC Q8TBE3; O00526: UPK2; NbExp=3; IntAct=EBI-12142257, EBI-10179682;
CC Q8TBE3; O95183: VAMP5; NbExp=3; IntAct=EBI-12142257, EBI-10191195;
CC Q8TBE3; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-12142257, EBI-12190699;
CC Q8TBE3; Q8N966: ZDHHC22; NbExp=3; IntAct=EBI-12142257, EBI-10268111;
CC Q8TBE3; O95159: ZFPL1; NbExp=3; IntAct=EBI-12142257, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- CAUTION: Encoded in intron of the gene CYFIP2 (opposite strand).
CC {ECO:0000305}.
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DR EMBL; AK289701; BAF82390.1; -; mRNA.
DR EMBL; AC016571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61607.1; -; Genomic_DNA.
DR EMBL; BC022570; AAH22570.1; -; mRNA.
DR CCDS; CCDS4337.1; -.
DR RefSeq; NP_001001343.2; NM_001001343.3.
DR AlphaFoldDB; Q8TBE3; -.
DR BioGRID; 135924; 89.
DR IntAct; Q8TBE3; 93.
DR STRING; 9606.ENSP00000310594; -.
DR iPTMnet; Q8TBE3; -.
DR PhosphoSitePlus; Q8TBE3; -.
DR BioMuta; FNDC9; -.
DR DMDM; 212276424; -.
DR MassIVE; Q8TBE3; -.
DR PaxDb; Q8TBE3; -.
DR PeptideAtlas; Q8TBE3; -.
DR PRIDE; Q8TBE3; -.
DR Antibodypedia; 2636; 34 antibodies from 14 providers.
DR DNASU; 408263; -.
DR Ensembl; ENST00000312349.5; ENSP00000310594.4; ENSG00000172568.5.
DR GeneID; 408263; -.
DR KEGG; hsa:408263; -.
DR MANE-Select; ENST00000312349.5; ENSP00000310594.4; NM_001001343.4; NP_001001343.2.
DR UCSC; uc003lwu.3; human.
DR CTD; 408263; -.
DR DisGeNET; 408263; -.
DR GeneCards; FNDC9; -.
DR HGNC; HGNC:33547; FNDC9.
DR HPA; ENSG00000172568; Group enriched (brain, pituitary gland).
DR neXtProt; NX_Q8TBE3; -.
DR OpenTargets; ENSG00000172568; -.
DR PharmGKB; PA162380178; -.
DR VEuPathDB; HostDB:ENSG00000172568; -.
DR eggNOG; ENOG502RYGM; Eukaryota.
DR GeneTree; ENSGT00390000013517; -.
DR InParanoid; Q8TBE3; -.
DR OMA; CKKILFP; -.
DR OrthoDB; 1299680at2759; -.
DR PhylomeDB; Q8TBE3; -.
DR TreeFam; TF335961; -.
DR PathwayCommons; Q8TBE3; -.
DR SignaLink; Q8TBE3; -.
DR BioGRID-ORCS; 408263; 12 hits in 1064 CRISPR screens.
DR GenomeRNAi; 408263; -.
DR Pharos; Q8TBE3; Tdark.
DR PRO; PR:Q8TBE3; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TBE3; protein.
DR Bgee; ENSG00000172568; Expressed in nucleus accumbens and 62 other tissues.
DR ExpressionAtlas; Q8TBE3; baseline and differential.
DR Genevisible; Q8TBE3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..224
FT /note="Fibronectin type III domain-containing protein 9"
FT /id="PRO_0000299409"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..101
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 175..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 50
FT /note="H -> N (in dbSNP:rs17852104)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_047138"
FT VARIANT 138
FT /note="V -> I (in dbSNP:rs10037485)"
FT /id="VAR_047139"
FT VARIANT 166
FT /note="P -> A (in dbSNP:rs17054522)"
FT /id="VAR_047140"
SQ SEQUENCE 224 AA; 25275 MW; 54D6E1C3BD28101F CRC64;
MNIEVGNISY TGAIISWSSS EPCLEDYYHI MYRPNWNSIF SGYLRYSFHH EEKVPRTISS
VVLEHLAPST LYFLCISCKK AAFPYRHYCT MFHTLDKSPL APGSSLVDPQ ISLWVLMAIL
LACFTAVLAF ICLQFWCVRC HEPRWSYRAG HMEEANGLVR WPEEAPDLGQ REEDLQGLPL
VEMPRKNSRD GAELDPEANQ DAPDAGALQR GGGDPPAILP HCGE
