FNDC9_MOUSE
ID FNDC9_MOUSE Reviewed; 226 AA.
AC Q8BJN4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Fibronectin type III domain-containing protein 9;
GN Name=Fndc9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- CAUTION: Encoded in intron of the gene CYFIP2 (opposite strand).
CC {ECO:0000305}.
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DR EMBL; AK081240; BAC38174.1; -; mRNA.
DR EMBL; AL713958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104394; AAI04395.1; -; mRNA.
DR EMBL; BC104395; AAI04396.1; -; mRNA.
DR CCDS; CCDS24574.1; -.
DR RefSeq; NP_796049.1; NM_177075.4.
DR AlphaFoldDB; Q8BJN4; -.
DR SMR; Q8BJN4; -.
DR STRING; 10090.ENSMUSP00000060509; -.
DR PhosphoSitePlus; Q8BJN4; -.
DR PaxDb; Q8BJN4; -.
DR PRIDE; Q8BJN4; -.
DR ProteomicsDB; 271788; -.
DR DNASU; 320116; -.
DR Ensembl; ENSMUST00000060185; ENSMUSP00000060509; ENSMUSG00000048721.
DR GeneID; 320116; -.
DR KEGG; mmu:320116; -.
DR UCSC; uc007ioe.1; mouse.
DR CTD; 408263; -.
DR MGI; MGI:2443410; Fndc9.
DR VEuPathDB; HostDB:ENSMUSG00000048721; -.
DR eggNOG; ENOG502RYGM; Eukaryota.
DR GeneTree; ENSGT00390000013517; -.
DR HOGENOM; CLU_107630_0_0_1; -.
DR InParanoid; Q8BJN4; -.
DR OMA; CKKILFP; -.
DR OrthoDB; 1299680at2759; -.
DR PhylomeDB; Q8BJN4; -.
DR TreeFam; TF335961; -.
DR BioGRID-ORCS; 320116; 4 hits in 70 CRISPR screens.
DR PRO; PR:Q8BJN4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BJN4; protein.
DR Bgee; ENSMUSG00000048721; Expressed in esophagus and 69 other tissues.
DR Genevisible; Q8BJN4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..226
FT /note="Fibronectin type III domain-containing protein 9"
FT /id="PRO_0000299410"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..101
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
SQ SEQUENCE 226 AA; 25656 MW; 8795AFCCD4E8260B CRC64;
MNIEVGNVSH TGAIISWSPS EPCLEDYYHI MYRPNWNSIF SGYLRYNFHH EEKVPRTITS
VALEHLAPST LYFLCISCKK AAFPYSHYCT MFHTLDKSPL AAGGSLVDPQ ISLWVLMAIL
LACFTAVLAF ICLQFWCLRC HEPRWSYRAG QMEEANGLVR WPEETPALGQ REEDLQGFPL
EELPRKNSGA RAKAEPEAEA IQDALEVVAL AREIGNQPAI LPHYRE
