ID   FNKC_DICDI              Reviewed;        1304 AA.
AC   Q8T126; Q551T8;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable inactive serine/threonine-protein kinase fnkC;
GN   Name=fnkC; Synonyms=FNIPK-C; ORFNames=DDB_G0276349;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000014; EAL69255.1; -; Genomic_DNA.
DR   RefSeq; XP_643187.1; XM_638095.1.
DR   AlphaFoldDB; Q8T126; -.
DR   SMR; Q8T126; -.
DR   STRING; 44689.DDB0231207; -.
DR   PaxDb; Q8T126; -.
DR   EnsemblProtists; EAL69255; EAL69255; DDB_G0276349.
DR   GeneID; 8620459; -.
DR   KEGG; ddi:DDB_G0276349; -.
DR   dictyBase; DDB_G0276349; fnkC.
DR   eggNOG; KOG1863; Eukaryota.
DR   eggNOG; KOG4645; Eukaryota.
DR   HOGENOM; CLU_261259_0_0_1; -.
DR   InParanoid; Q8T126; -.
DR   OMA; QKCLIQD; -.
DR   PRO; PR:Q8T126; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   CDD; cd00121; MATH; 2.
DR   Gene3D; 2.60.210.10; -; 2.
DR   InterPro; IPR008615; FNIP.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008974; TRAF-like.
DR   Pfam; PF05725; FNIP; 5.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00061; MATH; 2.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50144; MATH; 2.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Repeat.
FT   CHAIN           1..1304
FT                   /note="Probable inactive serine/threonine-protein kinase
FT                   fnkC"
FT                   /id="PRO_0000363982"
FT   DOMAIN          33..402
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REPEAT          514..556
FT                   /note="FNIP 1"
FT   REPEAT          710..753
FT                   /note="FNIP 2"
FT   REPEAT          754..797
FT                   /note="FNIP 3"
FT   REPEAT          798..841
FT                   /note="FNIP 4"
FT   REPEAT          900..943
FT                   /note="FNIP 5"
FT   DOMAIN          1025..1154
FT                   /note="MATH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   DOMAIN          1172..1291
FT                   /note="MATH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   REGION          208..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         39..47
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         68
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   1304 AA;  147936 MW;  9466E1F32B864714 CRC64;
     MDNNNSNNKN NEESNNIVIP ILSEKEKKHL YEFEIIRILK KDEFSTTCKA KKLSGQFNEK
     RVNFCIIKII KKRVKKFDSK KNEIIIEIDP RKEREILEKI KHICVLEYYG YSEDEDNGYI
     YTEYIQGGID IVETVTNKLL KEHSHSFQSE DIIRRCAFQL VLLLNHLHNN LHIIHGNINT
     DNVLIADQEF SLKLFDFSLS KDISYYSKDN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNA
     NNSNNNTLNN LSIVNNNSSS SSNDNSSEAE GGGGGGEASI TSTISTILSG SSSSQLSTPS
     TSLESSFSLE INLNDSSCYL IAPEIRNQQK ITSKGLSKKS DIWGLGCLLL LMVGGDPKIT
     TNFEPTIPYH LSNNCKNFIQ KCLIQDPYHR WDTNLLLTHK FIEKTSFENS CNNQNNSSTT
     TTTTINTYSI ENEENILLIN GSNGMNEFEE IPNYITTLKF QESFNMEIVN EMFTDSIVHL
     EFPQGFNKLD FNELPDFLST LIYHGEFNIE SNYHSKSLKP RDIPKSIIHL QLPNYNLKIR
     RNSIPDQTKF LILGSDLGEN EIQSLINLPP SIIDLEFGCD LELILNFLTQ EMIPSNITSL
     KINSQQIFLP FKRSNPFGLT NNIGNNNSNN GEQFNIPIDE LPLSKDINDL MILETVEINN
     LNQLNSNKLL TLTNRVGKLI FSKEFDEPLT IGCIKSRSIT SLKFNKGSRF NQLLVVGCLP
     VNLTSLEFGD RFNQALSVGC IPPKVTHLKF GRCFNQPLKL GVIPDSCTFI QFGSQFNQSL
     EPMVIPSSVK ELIFGSQYNQ PTIQGTFPDR IKKLVFSDDH DQFHSQDTLP KSLVHLEFGE
     SQNFNQILFN QSSSNLIPSL TPPPPIYQKL TTFIFNGYFT VPLKVFDLPL SITHLELPQY
     NDILEKDCIP SFVKTLVLGS SFTIIESFIN LPKSITSLSF GCDENVIGLI NQSLIPPNCN
     TLKINGQSIS LPITQTLQIF KNPILPTESS LILSQQQQQQ QQQQQMDLSV EYENQNFLTT
     NTLNQGSWII SINNFSNRKD QFYSPIFSLI GSNWRCKFYS NGKDASTSGK LSIFISNCDL
     LNNPFTIFLE KSISYKLTLI NQKNPNESIQ KSSSHTFSIK EFNHGYGSFI GLFSLLNPNN
     GFLVNNTIKV RIDAAPTSPL VNTYDKYNIG LNQAFSYSVP MMSKKSEPFI SPIFMSCGRK
     WIIKIYPMGQ PSSNYMSVFL EYRDEGEENV HFSLELISQL YPEQSIKYWV QYRFNSKSNS
     FGYPKFIGVS TLMDPDMGFL VNDTIILNVS ILQLKPIKKS FGFL