FNKD_DICDI
ID FNKD_DICDI Reviewed; 723 AA.
AC Q557D1; Q86I02;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Probable inactive serine/threonine-protein kinase fnkD {ECO:0000250|UniProtKB:Q8T126};
DE AltName: Full=FNIP repeat-containing protein D;
GN Name=fnkD-1 {ECO:0000312|dictyBase:DDB_G0273129};
GN Synonyms=FNIPK-D {ECO:0000250|UniProtKB:Q8T126}; ORFNames=DDB_G0273129;
GN and
GN Name=fnkD-2 {ECO:0000312|dictyBase:DDB_G0273641};
GN Synonyms=FNIPK-D {ECO:0000250|UniProtKB:Q8T126}; ORFNames=DDB_G0273641;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000312|EMBL:EAL70511.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000312|EMBL:EAL70511.1};
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive. {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. {ECO:0000255}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70511.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70782.1; -; Genomic_DNA.
DR RefSeq; XP_644437.1; XM_639345.1.
DR RefSeq; XP_644813.1; XM_639721.1.
DR AlphaFoldDB; Q557D1; -.
DR SMR; Q557D1; -.
DR STRING; 44689.DDB0231208; -.
DR PaxDb; Q557D1; -.
DR EnsemblProtists; EAL70511; EAL70511; DDB_G0273641.
DR EnsemblProtists; EAL70782; EAL70782; DDB_G0273129.
DR GeneID; 8618915; -.
DR GeneID; 8619062; -.
DR KEGG; ddi:DDB_G0273129; -.
DR KEGG; ddi:DDB_G0273641; -.
DR dictyBase; DDB_G0273129; fnkD-1.
DR dictyBase; DDB_G0273641; fnkD-2.
DR HOGENOM; CLU_382837_0_0_1; -.
DR OMA; NDINCKE; -.
DR PhylomeDB; Q557D1; -.
DR PRO; PR:Q557D1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR008615; FNIP.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF05725; FNIP; 3.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat.
FT CHAIN 1..723
FT /note="Probable inactive serine/threonine-protein kinase
FT fnkD"
FT /id="PRO_0000379439"
FT DOMAIN 33..276
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 301..342
FT /note="FNIP 1"
FT /evidence="ECO:0000255"
FT REPEAT 343..384
FT /note="FNIP 2"
FT /evidence="ECO:0000255"
FT REPEAT 385..426
FT /note="FNIP 3"
FT /evidence="ECO:0000255"
FT REPEAT 524..565
FT /note="FNIP 4"
FT /evidence="ECO:0000255"
FT REPEAT 566..606
FT /note="FNIP 5"
FT /evidence="ECO:0000255"
FT REPEAT 647..690
FT /note="FNIP 6"
FT /evidence="ECO:0000255"
SQ SEQUENCE 723 AA; 81892 MW; 33C00EA22C494C40 CRC64;
MDIISTTFDQ INTHIKFTNQ KKIEFQNHIE KEWEIITQLE SNEQFTVYMS KKLKGPNFTN
NRFGLCTVKK IKSQYFNENE ILNHIKLRDN KYVLKYYGCG KDNNQDVYIY LEFIEYSIPI
SKVKLIPNDS SIDNFNNVSN TIIELVTCKL VESLNCIHKD NKIVHGNIKG ENILLVNDES
EYGFSVKFIN FSLNIGYEDS IHLDMFNLGC VLIQMLGCDC TKDENIDFLF SKIPNHLVEK
FKKVISQLLS KNINNQILTD IISNKITTSL PKYSTLIGEP NDGLIYIGIQ NNSDGLILPL
FNQPICKKTF TYGVYYLSLS SFHRQLNVGV IPESIHTLEL ASFNQTILPG VIPTSVRTLK
LPSYNKTLTQ GSIPKGVRTL LLSSFNQPLT TDIIPKTVTI LKLQSFNQPI EWGALPCSLV
ELSLASYKQP LQWGVIPYYI STLELPLASA PFSEGSIPSG VSKLIQQGEI QQINKPIKIN
NENNQNYMSC SQNEFDSKLT LILNSKITRE SLFFGLKYLE LSTFNQSFET LPIPETVEYL
KLPMYNQPLT PKLLPSGIKF LILPSFNHPI RGESIPPSVI HLVFNKLFSV IESIPSSVKY
LDLGDEYYVY PGHLLHSVLS FRSGLKFRVT DPIPYSQSLT NLNLYNFNIE LLKNGISSNV
TSLTLGSNFT NIESLSNLPS SVTNLSFGIT TLNEKAISDI TKYVKSTVTT ITVNNEQIRK
KIN
