ID   FNR_AGGAP               Reviewed;          92 AA.
AC   Q47948;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Anaerobic regulatory protein;
DE   Flags: Fragment;
GN   Name=fnr;
OS   Aggregatibacter aphrophilus (Haemophilus aphrophilus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Aggregatibacter.
OX   NCBI_TaxID=732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13252;
RX   PubMed=8998988; DOI=10.1111/j.1574-6968.1996.tb08108.x;
RA   Hattori T., Takahashi K., Nakanishi T., Ohta H., Fukui K., Taniguchi S.,
RA   Takigawa M.;
RT   "Novel FNR homologues identified in four representative oral facultative
RT   anaerobes: Capnocytophaga ochracea, Capnocytophaga sputigena, Haemophilus
RT   aphrophilus, and Actinobacillus actinomycetemcomitans.";
RL   FEMS Microbiol. Lett. 137:213-220(1996).
CC   -!- FUNCTION: It is involved in the activation of genes necessary for
CC       anaerobic respiration.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: By anaerobiosis.
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DR   EMBL; D78254; BAA11318.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q47948; -.
DR   SMR; Q47948; -.
DR   STRING; 732.ADJ80_08040; -.
DR   eggNOG; COG0664; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00325; Crp; 1.
DR   PRINTS; PR00034; HTHCRP.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   2: Evidence at transcript level;
KW   4Fe-4S; Activator; Cytoplasm; DNA-binding; Iron; Iron-sulfur;
KW   Metal-binding; Transcription; Transcription regulation.
FT   CHAIN           <1..>92
FT                   /note="Anaerobic regulatory protein"
FT                   /id="PRO_0000100176"
FT   DOMAIN          43..>92
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   BINDING         1
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         92
SQ   SEQUENCE   92 AA;  10624 MW;  F6326332F5DF6AED CRC64;
     CEIPFDILDD LSGKMPKLRQ QIMRLMSSEI KSDQEMILLL SKMNAEERLA AFIYNLSQRY
     SARGFSAREF RLTMTRGDIG NYLGLTVETI SR