FNTA_SOLLC
ID FNTA_SOLLC Reviewed; 346 AA.
AC P93227;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha;
DE EC=2.5.1.58;
DE EC=2.5.1.59;
DE AltName: Full=CAAX farnesyltransferase subunit alpha;
DE AltName: Full=FTase-alpha;
DE AltName: Full=Ras proteins prenyltransferase subunit alpha;
DE AltName: Full=Type I protein geranyl-geranyltransferase subunit alpha;
DE Short=GGTase-I-alpha;
GN Name=FTA;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, AND SUBUNIT.
RC STRAIN=cv. VFNT Cherry LA1221;
RX PubMed=9121446; DOI=10.1128/mcb.17.4.1986;
RA Yalovsky S., Trueblood C.E., Callan K.L., Narita J.O., Jenkins S.M.,
RA Rine J., Gruissem W.;
RT "Plant farnesyltransferase can restore yeast Ras signaling and mating.";
RL Mol. Cell. Biol. 17:1986-1994(1997).
CC -!- FUNCTION: Essential subunit of both the farnesyltransferase and the
CC geranylgeranyltransferase complex. Contributes to the transfer of a
CC farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl
CC diphosphate to a cysteine at the fourth position from the C-terminus of
CC several proteins having the C-terminal sequence Cys-aliphatic-
CC aliphatic-X. {ECO:0000269|PubMed:9121446}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:13345, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11535,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:86019,
CC ChEBI:CHEBI:175763; EC=2.5.1.58;
CC Evidence={ECO:0000269|PubMed:9121446};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC ChEBI:CHEBI:86021; EC=2.5.1.59;
CC Evidence={ECO:0000269|PubMed:9121446};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:P29703};
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC {ECO:0000269|PubMed:9121446}.
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC family. {ECO:0000305}.
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DR EMBL; U83707; AAC49665.1; -; mRNA.
DR PIR; T07665; T07665.
DR AlphaFoldDB; P93227; -.
DR SMR; P93227; -.
DR STRING; 4081.Solyc06g073390.2.1; -.
DR PaxDb; P93227; -.
DR PRIDE; P93227; -.
DR eggNOG; KOG0530; Eukaryota.
DR InParanoid; P93227; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; P93227; baseline.
DR GO; GO:0005953; C:CAAX-protein geranylgeranyltransferase complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005965; C:protein farnesyltransferase complex; ISS:UniProtKB.
DR GO; GO:0004662; F:CAAX-protein geranylgeranyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004660; F:protein farnesyltransferase activity; ISS:UniProtKB.
DR GO; GO:0004661; F:protein geranylgeranyltransferase activity; ISS:UniProtKB.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblPlants.
DR GO; GO:0009788; P:negative regulation of abscisic acid-activated signaling pathway; IEA:EnsemblPlants.
DR GO; GO:0018343; P:protein farnesylation; ISS:UniProtKB.
DR GO; GO:0018344; P:protein geranylgeranylation; ISS:UniProtKB.
DR GO; GO:0008360; P:regulation of cell shape; IEA:EnsemblPlants.
DR GO; GO:0048509; P:regulation of meristem development; IEA:EnsemblPlants.
DR GO; GO:0009414; P:response to water deprivation; IEA:EnsemblPlants.
DR InterPro; IPR002088; Prenyl_trans_a.
DR Pfam; PF01239; PPTA; 4.
DR PROSITE; PS51147; PFTA; 5.
PE 1: Evidence at protein level;
KW Magnesium; Prenyltransferase; Reference proteome; Repeat; Transferase.
FT CHAIN 1..346
FT /note="Protein
FT farnesyltransferase/geranylgeranyltransferase type-1
FT subunit alpha"
FT /id="PRO_0000119750"
FT REPEAT 59..93
FT /note="PFTA 1"
FT REPEAT 94..128
FT /note="PFTA 2"
FT REPEAT 130..164
FT /note="PFTA 3"
FT REPEAT 165..198
FT /note="PFTA 4"
FT REPEAT 205..239
FT /note="PFTA 5"
SQ SEQUENCE 346 AA; 40103 MW; 17952611F8D8CACE CRC64;
MDSCEVTKTR IPFKERPDWA DVKPVPQDDG PCPVVPIAYT EDFSETMDYF RAIYVADERS
TRALQLTGEA IQLNPGNYTV WQFRRVVLEA LGVDLREELK FVDRIAGENT KNYQIWHHRR
WLAEKLGADA VTNELEFTKK IFSQDAKNYH AWSHRQWVLQ ALGGWEDELA YCQQLLEDDI
YNNSAWNQRY FVVTRSPLLG GLVAMRELEV NYTVQAIRAS PENESPWRYL RGLYKNDTQS
LVQDSQVASV LWDVLTSQNS HVHALRFLLD LLCHDLEPSQ ELKSAVDVLT PQSCSPDLAL
TKKICSILEH ADPMRVKYWN WRKSMVRVQL LQSQNAERLA NLSVQE
