ALAE_SHIFL
ID ALAE_SHIFL Reviewed; 149 AA.
AC P64553; P76626;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=L-alanine exporter AlaE {ECO:0000255|HAMAP-Rule:MF_00914};
GN Name=alaE {ECO:0000255|HAMAP-Rule:MF_00914};
GN OrderedLocusNames=SF2698, S2884;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Exports L-alanine. {ECO:0000255|HAMAP-Rule:MF_00914}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00914}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00914}.
CC -!- SIMILARITY: Belongs to the AlaE exporter family. {ECO:0000255|HAMAP-
CC Rule:MF_00914}.
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DR EMBL; AE005674; AAN44191.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18019.1; -; Genomic_DNA.
DR RefSeq; NP_708484.1; NC_004337.2.
DR RefSeq; WP_000492656.1; NZ_WPGW01000014.1.
DR AlphaFoldDB; P64553; -.
DR STRING; 198214.SF2698; -.
DR EnsemblBacteria; AAN44191; AAN44191; SF2698.
DR EnsemblBacteria; AAP18019; AAP18019; S2884.
DR GeneID; 1025707; -.
DR GeneID; 66673460; -.
DR KEGG; sfl:SF2698; -.
DR KEGG; sfx:S2884; -.
DR PATRIC; fig|198214.7.peg.3213; -.
DR HOGENOM; CLU_126493_0_0_6; -.
DR OMA; ADWHQIA; -.
DR OrthoDB; 1555708at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0034639; F:L-amino acid efflux transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032973; P:amino acid export across plasma membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00914; L_Ala_exporter; 1.
DR InterPro; IPR010574; Ala_export_AlaE.
DR Pfam; PF06610; AlaE; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..149
FT /note="L-alanine exporter AlaE"
FT /id="PRO_0000169305"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00914"
SQ SEQUENCE 149 AA; 16949 MW; 0B1D31F498DBE4BC CRC64;
MFSPQSRLRH AVADTFAMVV YCSVVNMCIE VFLSGMSFEQ SFYSRLVAIP VNILIAWPYG
MYRDLFMRAA RKVSPSGWIK NLADILAYVT FQSPVYVAIL LVVGADWHQI MAAVSSNIVV
SMLMGAVYGY FLDYCRRLFK VSRYQQVKA
