ID   FOCA_HAEIN              Reviewed;         284 AA.
AC   P43756;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Probable formate transporter;
DE   AltName: Full=Formate channel;
GN   Name=focA; OrderedLocusNames=HI_0181;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in the bidirectional transport of formate.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FNT transporter (TC 2.A.44) family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC21850.1; -; Genomic_DNA.
DR   PIR; G64052; G64052.
DR   RefSeq; NP_438349.1; NC_000907.1.
DR   RefSeq; WP_005694105.1; NC_000907.1.
DR   AlphaFoldDB; P43756; -.
DR   SMR; P43756; -.
DR   STRING; 71421.HI_0181; -.
DR   EnsemblBacteria; AAC21850; AAC21850; HI_0181.
DR   KEGG; hin:HI_0181; -.
DR   PATRIC; fig|71421.8.peg.185; -.
DR   eggNOG; COG2116; Bacteria.
DR   HOGENOM; CLU_036896_3_0_6; -.
DR   OMA; MIWFPIM; -.
DR   PhylomeDB; P43756; -.
DR   BioCyc; HINF71421:G1GJ1-191-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015499; F:formate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015724; P:formate transport; IBA:GO_Central.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR000292; For/NO2_transpt.
DR   InterPro; IPR024002; For/NO2_transpt_CS.
DR   InterPro; IPR023999; Formate_transptr_FocA_put.
DR   PANTHER; PTHR30520; PTHR30520; 1.
DR   Pfam; PF01226; Form_Nir_trans; 1.
DR   TIGRFAMs; TIGR00790; fnt; 1.
DR   TIGRFAMs; TIGR04060; formate_focA; 1.
DR   PROSITE; PS01005; FORMATE_NITRITE_TP_1; 1.
DR   PROSITE; PS01006; FORMATE_NITRITE_TP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..284
FT                   /note="Probable formate transporter"
FT                   /id="PRO_0000094720"
FT   TOPO_DOM        1..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..71
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..119
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..167
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..194
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  30850 MW;  075E621E5C624BF1 CRC64;
     MASENQKLSS VALTPVEATD YAENTATYKA NKRPFLSFMS GISAGACIAL AFVFYTTTQT
     ASAGAPWGLT KLVGGLVFSL GVIMVVILGS ELFTSSTLTL VARVGGRITT TQMIRNWIVV
     YLGNFVGGLF IAAVIWFSGQ TMAANGQWGL TILATAQHKI HHTWFEAFNL GILCNIMVCV
     AVWMSYSGKT VTDKAFIMIM PIGLFVASGF EHCVANMFMI PMGIITAHFS TPEFWQQIGV
     DPMKYADLDL YHFIVKNLIP VTLGNIVGGA ICIGVFQRYL TKTH