ID   3MGH_RICTY              Reviewed;         223 AA.
AC   Q68X22;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
DE            EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
GN   OrderedLocusNames=RT0340;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00527}.
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DR   EMBL; AE017197; AAU03820.1; -; Genomic_DNA.
DR   RefSeq; WP_011190804.1; NC_006142.1.
DR   AlphaFoldDB; Q68X22; -.
DR   SMR; Q68X22; -.
DR   STRING; 257363.RT0340; -.
DR   EnsemblBacteria; AAU03820; AAU03820; RT0340.
DR   KEGG; rty:RT0340; -.
DR   eggNOG; COG2094; Bacteria.
DR   HOGENOM; CLU_060471_3_0_5; -.
DR   OMA; WYLKNSR; -.
DR   OrthoDB; 1385409at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd00540; AAG; 1.
DR   Gene3D; 3.10.300.10; -; 1.
DR   HAMAP; MF_00527; 3MGH; 1.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR003180; MPG.
DR   InterPro; IPR036995; MPG_sf.
DR   PANTHER; PTHR10429; PTHR10429; 1.
DR   Pfam; PF02245; Pur_DNA_glyco; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   TIGRFAMs; TIGR00567; 3mg; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase.
FT   CHAIN           1..223
FT                   /note="Putative 3-methyladenine DNA glycosylase"
FT                   /id="PRO_0000265056"
SQ   SEQUENCE   223 AA;  25246 MW;  33075B6B3AA6C0CA CRC64;
     MNKLIPLPRE FFARDTNLVS TELIGKVLYF QGTTAIITET ESYIGNDDPA CHAARGRTKR
     TDVMFGPAGF SYVYLIYGMY HCLNFVTEDE GFPAATLIRG VYVISHNDLY TIYTAKVKSQ
     ITDEKTQSII ISEDRRSTKF DIPNLEESNL YLNGPGKLCK YLGINTTHNK CDLINNKDFF
     VSDIGLNLPY STTKRIGITK GTDKLWRYIV TDNKNALLNI NIL