ID   ALB1E_PEA               Reviewed;         130 AA.
AC   P62930; P08687; Q40999; Q7XZC1; Q9M3X4;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Albumin-1 E;
DE   AltName: Full=PA1 E;
DE   AltName: Full=PsaA1b014;
DE            Short=Psa;
DE   Contains:
DE     RecName: Full=Albumin-1 E chain b;
DE     AltName: Full=Leginsulin E;
DE     AltName: Full=PA1b E;
DE   Contains:
DE     RecName: Full=Albumin-1 E chain a;
DE     AltName: Full=PA1a E;
DE   Flags: Precursor;
OS   Pisum sativum (Garden pea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX   NCBI_TaxID=3888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Greenfeast;
RX   PubMed=9749674; DOI=10.1007/s004380050817;
RA   Morton R.L., Ellery A.J., Higgins T.J.;
RT   "Downstream elements from the pea albumin 1 gene confer sulfur
RT   responsiveness on a reporter gene.";
RL   Mol. Gen. Genet. 259:309-316(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Frisson; TISSUE=Seed;
RX   AGRICOLA=IND43645431; DOI=10.1016/j.plantsci.2004.04.018;
RA   Louis S., Delobel B., Gressent F., Rahioui I., Quillien L., Vallier A.,
RA   Rahbe Y.;
RT   "Molecular and biological screening for insect-toxic seed albumins from
RT   four legume species.";
RL   Plant Sci. 167:705-714(2004).
CC   -!- FUNCTION: PA1b binds to basic 7S globulin (BG) and stimulates its
CC       phosphorylation activity. Involved in the signal transduction system to
CC       regulate the growth and differentiation as a hormone peptide. Toxic to
CC       various insects through binding to a high affinity binding site in the
CC       insect gut (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- PTM: The C-terminal glycine may be removed from PA1b.
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DR   EMBL; M81864; AAC61879.1; -; Genomic_DNA.
DR   EMBL; AJ574795; CAE00467.1; -; Genomic_DNA.
DR   AlphaFoldDB; P62930; -.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012512; Albumin_I.
DR   InterPro; IPR032000; Albumin_I_a.
DR   Pfam; PF08027; Albumin_I; 1.
DR   Pfam; PF16720; Albumin_I_a; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Seed storage protein; Signal; Storage protein;
KW   Toxin.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..63
FT                   /note="Albumin-1 E chain b"
FT                   /id="PRO_0000032231"
FT   PROPEP          64..69
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000032232"
FT   CHAIN           70..122
FT                   /note="Albumin-1 E chain a"
FT                   /id="PRO_0000032233"
FT   PROPEP          123..130
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000032234"
FT   DISULFID        29..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..58
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   130 AA;  13778 MW;  C534DE67A304F749 CRC64;
     MASVKLASLI VLFATLGMFL TKNVGAASCN GVCSPFEMPP CGSSACRCIP VGLLIGYCRN
     PSGVFLKGND EHPNLCESDA DCKKKGSGNF CGHYPNPDIE YGWCFASKSE AEDVFSKITP
     KDLLKSVSTA