ALB1_YEAST
ID ALB1_YEAST Reviewed; 175 AA.
AC P47019; D6VW64;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Ribosome biogenesis protein ALB1;
GN Name=ALB1; OrderedLocusNames=YJL122W; ORFNames=J0723;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8948101;
RX DOI=10.1002/(sici)1097-0061(199611)12:14<1471::aid-yea30>3.0.co;2-4;
RA Cziepluch C., Kordes E., Pujol A., Jauniaux J.-C.;
RT "Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19
RT open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14,
RT RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta
RT elements and a Ty4 transposon.";
RL Yeast 12:1471-1474(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP COPURIFICATION WITH RIBOSOMAL COMPLEXES, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16702403; DOI=10.1101/gad.1422006;
RA Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.;
RT "Systematic identification and functional screens of uncharacterized
RT proteins associated with eukaryotic ribosomal complexes.";
RL Genes Dev. 20:1294-1307(2006).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE PRE-60S RIBOSOME, AND
RP INTERACTION WITH ARX1.
RX PubMed=16651379; DOI=10.1083/jcb.200510080;
RA Lebreton A., Saveanu C., Decourty L., Rain J.-C., Jacquier A.,
RA Fromont-Racine M.;
RT "A functional network involved in the recycling of nucleocytoplasmic pre-
RT 60S factors.";
RL J. Cell Biol. 173:349-360(2006).
RN [8]
RP FUNCTION.
RX PubMed=16544271; DOI=10.1002/yea.1353;
RA Wade C.H., Umbarger M.A., McAlear M.A.;
RT "The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains
RT over 200 genes.";
RL Yeast 23:293-306(2006).
RN [9]
RP FUNCTION.
RX PubMed=17242366; DOI=10.1073/pnas.0610704104;
RA Meyer A.E., Hung N.-J., Yang P., Johnson A.W., Craig E.A.;
RT "The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal
RT subunit biogenesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1558-1563(2007).
RN [10]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17652132; DOI=10.1261/rna.585007;
RA Demoinet E., Jacquier A., Lutfalla G., Fromont-Racine M.;
RT "The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling
RT of preribosomal factors in Saccharomyces cerevisiae.";
RL RNA 13:1570-1581(2007).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: With ARX1, involved in proper assembly of pre-ribosomal
CC particles during the biogenesis of the 60S ribosomal subunit.
CC Accompanies the pre-60S particles to the cytoplasm.
CC {ECO:0000269|PubMed:16544271, ECO:0000269|PubMed:16651379,
CC ECO:0000269|PubMed:17242366, ECO:0000269|PubMed:17652132}.
CC -!- SUBUNIT: Component of the nucleoplasmic and cytoplasmic pre-60S
CC ribosomal particles. Interacts directly with ARX1.
CC {ECO:0000269|PubMed:16651379}.
CC -!- INTERACTION:
CC P47019; Q03862: ARX1; NbExp=3; IntAct=EBI-26061, EBI-31385;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: Present with 4780 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the ALB1 family. {ECO:0000305}.
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DR EMBL; Z49397; CAA89417.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08680.1; -; Genomic_DNA.
DR PIR; S56903; S56903.
DR RefSeq; NP_012413.1; NM_001181555.1.
DR AlphaFoldDB; P47019; -.
DR SMR; P47019; -.
DR BioGRID; 33634; 104.
DR DIP; DIP-6452N; -.
DR IntAct; P47019; 24.
DR MINT; P47019; -.
DR STRING; 4932.YJL122W; -.
DR iPTMnet; P47019; -.
DR MaxQB; P47019; -.
DR PaxDb; P47019; -.
DR PRIDE; P47019; -.
DR EnsemblFungi; YJL122W_mRNA; YJL122W; YJL122W.
DR GeneID; 853320; -.
DR KEGG; sce:YJL122W; -.
DR SGD; S000003658; ALB1.
DR VEuPathDB; FungiDB:YJL122W; -.
DR eggNOG; ENOG502S14D; Eukaryota.
DR HOGENOM; CLU_103824_0_0_1; -.
DR InParanoid; P47019; -.
DR OMA; DLYFQNK; -.
DR BioCyc; YEAST:G3O-31573-MON; -.
DR PRO; PR:P47019; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47019; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IGI:SGD.
DR InterPro; IPR022784; Ribosome_bgen_Alb1.
DR Pfam; PF09135; Alb1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis; Transport.
FT CHAIN 1..175
FT /note="Ribosome biogenesis protein ALB1"
FT /id="PRO_0000203041"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 175 AA; 19287 MW; 3DECC43269EBB6D3 CRC64;
MPSKNSINRP KLTSNLHHKV HSLNKKRAQR ERAGLLKPAR SSVNSKSGEI KSVALDLYFQ
NKKNESQNST AVTLQNASSS PASITTRTLS KKRAKKIERN LKYATQRKLL VDASAKLEDE
MDIDLDGGKK VKENEKKSSL TLVKEALWSV IDDTASQGLI IENGQGTTLG GPFFP
