ALB3_ARATH
ID ALB3_ARATH Reviewed; 462 AA.
AC Q8LBP4; O04665;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Inner membrane protein ALBINO3, chloroplastic;
DE Flags: Precursor;
GN Name=ALB3; OrderedLocusNames=At2g28800; ORFNames=F8N16.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=9165749; DOI=10.2307/3870427;
RA Sundberg E., Slagter J.G., Fridborg I., Cleary S.P., Robinson C.,
RA Coupland G.;
RT "ALBINO3, an Arabidopsis nuclear gene essential for chloroplast
RT differentiation, encodes a chloroplast protein that shows homology to
RT proteins present in bacterial membranes and yeast mitochondria.";
RL Plant Cell 9:717-730(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=10636840; DOI=10.1074/jbc.275.3.1529;
RA Moore M., Harrison M.S., Peterson E.C., Henry R.;
RT "Chloroplast Oxa1p homolog albino3 is required for post-translational
RT integration of the light harvesting chlorophyll-binding protein into
RT thylakoid membranes.";
RL J. Biol. Chem. 275:1529-1532(2000).
RN [7]
RP FUNCTION.
RX PubMed=11524428; DOI=10.1074/jbc.m106523200;
RA Woolhead C.A., Thompson S.J., Moore M., Tissier C., Mant A., Rodger A.,
RA Henry R., Robinson C.;
RT "Distinct Albino3-dependent and -independent pathways for thylakoid
RT membrane protein insertion.";
RL J. Biol. Chem. 276:40841-40846(2001).
RN [8]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH SCY1.
RX PubMed=12217076; DOI=10.1042/bj20021291;
RA Klostermann E., Droste Gen Helling I., Carde J.P., Schunemann D.;
RT "The thylakoid membrane protein ALB3 associates with the cpSecY-translocase
RT in Arabidopsis thaliana.";
RL Biochem. J. 368:777-781(2002).
RN [9]
RP FUNCTION.
RX PubMed=11891220; DOI=10.1074/jbc.m110857200;
RA Jiang F., Yi L., Moore M., Chen M., Rohl T., Van Wijk K.-J., De Gier J.-W.,
RA Henry R., Dalbey R.E.;
RT "Chloroplast YidC homolog Albino3 can functionally complement the bacterial
RT YidC depletion strain and promote membrane insertion of both bacterial and
RT chloroplast thylakoid proteins.";
RL J. Biol. Chem. 277:19281-19288(2002).
RN [10]
RP INTERACTION WITH CPFTSY AND CPSRP COMPLEX.
RX PubMed=14517205; DOI=10.1083/jcb.200307067;
RA Moore M., Goforth R.L., Mori H., Henry R.;
RT "Functional interaction of chloroplast SRP/FtsY with the ALB3 translocase
RT in thylakoids: substrate not required.";
RL J. Cell Biol. 162:1245-1254(2003).
RN [11]
RP INTERACTION WITH SECE1 AND SCY1.
RX PubMed=15988575; DOI=10.1007/s00253-005-0029-3;
RA Pasch J.C., Nickelsen J., Schunemann D.;
RT "The yeast split-ubiquitin system to study chloroplast membrane protein
RT interactions.";
RL Appl. Microbiol. Biotechnol. 69:440-447(2005).
RN [12]
RP INTERACTION WITH CAO/CPSRP43.
RX PubMed=17513500; DOI=10.1105/tpc.106.048959;
RA Tzvetkova-Chevolleau T., Hutin C., Noel L.D., Goforth R., Carde J.P.,
RA Caffarri S., Sinning I., Groves M., Teulon J.M., Hoffman N.E., Henry R.,
RA Havaux M., Nussaume L.;
RT "Canonical signal recognition particle components can be bypassed for
RT posttranslational protein targeting in chloroplasts.";
RL Plant Cell 19:1635-1648(2007).
RN [13]
RP RETRACTED PAPER.
RX PubMed=17601825; DOI=10.1105/tpc.107.050526;
RA Ma J., Peng L., Guo J., Lu Q., Lu C., Zhang L.;
RT "LPA2 is required for efficient assembly of photosystem II in Arabidopsis
RT thaliana.";
RL Plant Cell 19:1980-1993(2007).
RN [14]
RP RETRACTION NOTICE OF PUBMED:17601825.
RX PubMed=27895223; DOI=10.1105/tpc.16.00881;
RA Ma J., Peng L., Guo J., Lu Q., Lu C., Zhang L.;
RL Plant Cell 28:3061-3061(2016).
RN [15]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [16]
RP INTERACTION WITH CAO/CPSRP43; FFC/CPSRP54; CPFTSY AND LHCP.
RX PubMed=20828566; DOI=10.1016/j.febslet.2010.08.053;
RA Bals T., Duenschede B., Funke S., Schuenemann D.;
RT "Interplay between the cpSRP pathway components, the substrate LHCP and the
RT translocase Alb3: an in vivo and in vitro study.";
RL FEBS Lett. 584:4138-4144(2010).
RN [17]
RP INTERACTION WITH CAO/CPSRP43, AND MUTAGENESIS OF 376-LYS-ARG-377 AND
RP 454-LYS-ARG-455.
RX PubMed=20018841; DOI=10.1074/jbc.m109.084996;
RA Falk S., Ravaud S., Koch J., Sinning I.;
RT "The C terminus of the Alb3 membrane insertase recruits cpSRP43 to the
RT thylakoid membrane.";
RL J. Biol. Chem. 285:5954-5962(2010).
RN [18]
RP INTERACTION WITH PAM68.
RX PubMed=20923938; DOI=10.1105/tpc.110.077453;
RA Armbruster U., Zuhlke J., Rengstl B., Kreller R., Makarenko E., Ruhle T.,
RA Schunemann D., Jahns P., Weisshaar B., Nickelsen J., Leister D.;
RT "The Arabidopsis thylakoid protein PAM68 is required for efficient D1
RT biogenesis and photosystem II assembly.";
RL Plant Cell 22:3439-3460(2010).
RN [19]
RP RETRACTED PAPER.
RX PubMed=20605914; DOI=10.1104/pp.110.159558;
RA Cai W., Ma J., Chi W., Zou M., Guo J., Lu C., Zhang L.;
RT "Cooperation of LPA3 and LPA2 is essential for photosystem II assembly in
RT Arabidopsis.";
RL Plant Physiol. 154:109-120(2010).
RN [20]
RP RETRACTION NOTICE OF PUBMED:20605914.
RX PubMed=28154118; DOI=10.1104/pp.16.01908;
RA Cai W., Ma J., Chi W., Zou M., Guo J., Lu C., Zhang L.;
RL Plant Physiol. 173:1526-1526(2017).
RN [21]
RP INTERACTION WITH CAO/CPSRP43, AND SUBUNIT.
RX PubMed=21832051; DOI=10.1074/jbc.m111.250746;
RA Dunschede B., Bals T., Funke S., Schunemann D.;
RT "Interaction studies between the chloroplast signal recognition particle
RT subunit cpSRP43 and the full-length translocase Alb3 reveal a membrane-
RT embedded binding region in Alb3.";
RL J. Biol. Chem. 286:35187-35195(2011).
RN [22]
RP INTERACTION WITH TERC.
RX PubMed=24612058; DOI=10.1111/tpj.12474;
RA Schneider A., Steinberger I., Strissel H., Kunz H.H., Manavski N.,
RA Meurer J., Burkhard G., Jarzombski S., Schunemann D., Geimer S.,
RA Flugge U.I., Leister D.;
RT "The Arabidopsis tellurite resistance C protein together with ALB3 is
RT involved in photosystem II protein synthesis.";
RL Plant J. 78:344-356(2014).
RN [23]
RP INTERACTION WITH ALB4.
RX PubMed=26265777; DOI=10.1104/pp.15.00376;
RA Troesch R., Toepel M., Flores-Perez U., Jarvis P.;
RT "Genetic and physical interaction studies reveal functional similarities
RT between ALBINO3 and ALBINO4 in Arabidopsis.";
RL Plant Physiol. 169:1292-1306(2015).
RN [24]
RP INTERACTION WITH STIC2.
RX PubMed=28684427; DOI=10.1105/tpc.16.00962;
RA Bedard J., Troesch R., Wu F., Ling Q., Flores-Perez U., Toepel M.,
RA Nawaz F., Jarvis P.;
RT "Suppressors of the chloroplast protein import mutant tic40 reveal a
RT genetic link between protein import and thylakoid biogenesis.";
RL Plant Cell 29:1726-1747(2017).
RN [25]
RP X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 453-461.
RX PubMed=26568381; DOI=10.1038/ncomms9875;
RA Horn A., Hennig J., Ahmed Y.L., Stier G., Wild K., Sattler M., Sinning I.;
RT "Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3
RT insertase interaction.";
RL Nat. Commun. 6:8875-8875(2015).
CC -!- FUNCTION: Required for the insertion of some light harvesting
CC chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid
CC membrane. Required for the insertion of LHCB1, LHCB4.1 and LHCB5
CC proteins into thylakoid membrane, while it is not required for
CC insertion of proteins PsbX, PsbW and PsbY.
CC {ECO:0000269|PubMed:10636840, ECO:0000269|PubMed:11524428,
CC ECO:0000269|PubMed:11891220, ECO:0000269|PubMed:9165749}.
CC -!- SUBUNIT: Homodimer. Forms a complex with CPFTSY and the signal
CC recognition particle (cpSRP). Interacts (via C-terminus) with
CC CAO/cpSRP43 (via chromodomains 2 and 3) and with LHCP. Interacts with
CC PAM68, SECE1 and SCY1 (PubMed:12217076, PubMed:14517205,
CC PubMed:15988575, PubMed:17513500, PubMed:20018841, PubMed:20828566,
CC PubMed:20923938, PubMed:21832051). Interacts with TERC
CC (PubMed:24612058). Interacts with ALB4 (PubMed:26265777). Interacts
CC with STIC2 (PubMed:28684427). {ECO:0000269|PubMed:12217076,
CC ECO:0000269|PubMed:14517205, ECO:0000269|PubMed:15988575,
CC ECO:0000269|PubMed:17513500, ECO:0000269|PubMed:20018841,
CC ECO:0000269|PubMed:20828566, ECO:0000269|PubMed:20923938,
CC ECO:0000269|PubMed:21832051, ECO:0000269|PubMed:24612058,
CC ECO:0000269|PubMed:26265777, ECO:0000269|PubMed:28684427}.
CC -!- INTERACTION:
CC Q8LBP4; Q9FYL3: ALB4; NbExp=6; IntAct=EBI-1806831, EBI-16630560;
CC Q8LBP4; O22265: CAO; NbExp=10; IntAct=EBI-1806831, EBI-780656;
CC Q8LBP4; O80842: CPFTSY; NbExp=2; IntAct=EBI-1806831, EBI-2353373;
CC Q8LBP4; Q38885: SCY1; NbExp=8; IntAct=EBI-1806831, EBI-1806802;
CC Q8LBP4; O82230: STIC2; NbExp=4; IntAct=EBI-1806831, EBI-4428759;
CC Q8LBP4; P27490: CAB8; Xeno; NbExp=2; IntAct=EBI-1806831, EBI-8295162;
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000269|PubMed:12217076, ECO:0000269|PubMed:9165749}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:12217076,
CC ECO:0000269|PubMed:9165749}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8LBP4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8LBP4-2; Sequence=VSP_011358, VSP_011359;
CC -!- TISSUE SPECIFICITY: Mainly expressed in organs that contain green
CC tissues such as leaves, flower buds and stems.
CC {ECO:0000269|PubMed:9165749}.
CC -!- DOMAIN: The C-terminus (339-462) is required for interaction with
CC cpSRP.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC (TC 2.A.9.2) family.
CC {ECO:0000305}.
CC -!- CAUTION: Two articles reported an interaction with LPA2; however, these
CC papers were later retracted. {ECO:0000305|PubMed:17601825,
CC ECO:0000305|PubMed:20605914, ECO:0000305|PubMed:27895223,
CC ECO:0000305|PubMed:28154118}.
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DR EMBL; U89272; AAB61458.1; -; mRNA.
DR EMBL; AC005727; AAC79585.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08172.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08173.1; -; Genomic_DNA.
DR EMBL; BT002436; AAO00796.1; -; mRNA.
DR EMBL; BT006602; AAP31946.1; -; mRNA.
DR EMBL; AY087081; AAM64642.1; -; mRNA.
DR PIR; A84689; A84689.
DR RefSeq; NP_180446.1; NM_128439.3. [Q8LBP4-1]
DR RefSeq; NP_850125.1; NM_179794.2. [Q8LBP4-2]
DR PDB; 5E4W; X-ray; 2.80 A; E/F=453-461.
DR PDBsum; 5E4W; -.
DR AlphaFoldDB; Q8LBP4; -.
DR SMR; Q8LBP4; -.
DR BioGRID; 2779; 10.
DR IntAct; Q8LBP4; 30.
DR MINT; Q8LBP4; -.
DR STRING; 3702.AT2G28800.1; -.
DR TCDB; 2.A.9.2.1; the membrane protein insertase (yidc/alb3/oxa1) family.
DR iPTMnet; Q8LBP4; -.
DR PaxDb; Q8LBP4; -.
DR PRIDE; Q8LBP4; -.
DR ProteomicsDB; 244706; -. [Q8LBP4-1]
DR EnsemblPlants; AT2G28800.1; AT2G28800.1; AT2G28800. [Q8LBP4-1]
DR EnsemblPlants; AT2G28800.2; AT2G28800.2; AT2G28800. [Q8LBP4-2]
DR GeneID; 817429; -.
DR Gramene; AT2G28800.1; AT2G28800.1; AT2G28800. [Q8LBP4-1]
DR Gramene; AT2G28800.2; AT2G28800.2; AT2G28800. [Q8LBP4-2]
DR KEGG; ath:AT2G28800; -.
DR Araport; AT2G28800; -.
DR TAIR; locus:2053230; AT2G28800.
DR eggNOG; KOG1239; Eukaryota.
DR InParanoid; Q8LBP4; -.
DR OMA; IHVPYAY; -.
DR PhylomeDB; Q8LBP4; -.
DR BioCyc; ARA:AT2G28800-MON; -.
DR BioCyc; MetaCyc:AT2G28800-MON; -.
DR PRO; PR:Q8LBP4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8LBP4; baseline and differential.
DR Genevisible; Q8LBP4; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0009534; C:chloroplast thylakoid; HDA:TAIR.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005777; C:peroxisome; HDA:TAIR.
DR GO; GO:0032991; C:protein-containing complex; IMP:CAFA.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; IPI:CAFA.
DR GO; GO:0070208; P:protein heterotrimerization; IMP:CAFA.
DR GO; GO:0045038; P:protein import into chloroplast thylakoid membrane; IDA:TAIR.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0072598; P:protein localization to chloroplast; IMP:TAIR.
DR GO; GO:0010027; P:thylakoid membrane organization; IMP:TAIR.
DR DisProt; DP00662; -.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chloroplast; Membrane; Plastid;
KW Reference proteome; Thylakoid; Transit peptide; Transmembrane;
KW Transmembrane helix.
FT TRANSIT 1..56
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 57..462
FT /note="Inner membrane protein ALBINO3, chloroplastic"
FT /id="PRO_0000020365"
FT TOPO_DOM 57..130
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..205
FT /note="Stromal"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..232
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..278
FT /note="Stromal"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..317
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..462
FT /note="Stromal"
FT /evidence="ECO:0000255"
FT REGION 314..318
FT /note="Interaction with CAO/cpSRP43"
FT REGION 374..388
FT /note="Interaction with CAO/cpSRP43"
FT REGION 393..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..432
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 340..348
FT /note="TNNVLSTAQ -> VSLSLKLLI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_011358"
FT VAR_SEQ 349..462
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_011359"
FT MUTAGEN 376..377
FT /note="KR->AA: Decreased interaction with CAO/cpSRP43. Loss
FT of interaction with CAO/cpSRP43; when associated with 454-
FT A-A-455."
FT /evidence="ECO:0000269|PubMed:20018841"
FT MUTAGEN 454..455
FT /note="KR->AA: Decreased interaction with CAO/cpSRP43. Loss
FT of interaction with CAO/cpSRP43; when associated with 376-
FT A-A-377."
FT /evidence="ECO:0000269|PubMed:20018841"
FT CONFLICT 75
FT /note="A -> S (in Ref. 5; AAM64642)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="G -> S (in Ref. 5; AAM64642)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="V -> L (in Ref. 5; AAM64642)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="R -> T (in Ref. 5; AAM64642)"
FT /evidence="ECO:0000305"
FT STRAND 455..459
FT /evidence="ECO:0007829|PDB:5E4W"
SQ SEQUENCE 462 AA; 50245 MW; 2BBF7AF5BA2E6DDE CRC64;
MARVLVSSPS SFFGSPLIKP SSSLRHSGVG GGGTAQFLPY RSNNNKLFTT STTVRFSLNE
IPPFHGLDSS VDIGAIFTRA ESLLYTIADA AVVGADSVVT TDSSAVQKSG GWFGFISDAM
ELVLKILKDG LSAVHVPYAY GFAIILLTII VKAATYPLTK QQVESTLAMQ NLQPKIKAIQ
QRYAGNQERI QLETSRLYKQ AGVNPLAGCL PTLATIPVWI GLYQALSNVA NEGLFTEGFF
WIPSLGGPTS IAARQSGSGI SWLFPFVDGH PPLGWYDTVA YLVLPVLLIA SQYVSMEIMK
PPQTDDPAQK NTLLVFKFLP LMIGYFALSV PSGLSIYWLT NNVLSTAQQV YLRKLGGAKP
NMDENASKII SAGRAKRSIA QPDDAGERFR QLKEQEKRSK KNKAVAKDTV ELVEESQSES
EEGSDDEEEE AREGALASST TSKPLPEVGQ RRSKRSKRKR TV
