ALB4_ARATH
ID ALB4_ARATH Reviewed; 499 AA.
AC Q9FYL3; Q1RPP7; Q9FYL4;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=ALBINO3-like protein 1, chloroplastic {ECO:0000305};
DE AltName: Full=Arabidopsis thaliana envelope membrane integrase {ECO:0000305};
DE AltName: Full=Protein ALBINA 4 {ECO:0000305};
DE Short=Ath4 {ECO:0000305};
DE AltName: Full=Protein ARTEMIS {ECO:0000303|PubMed:12169665};
DE AltName: Full=Suppressor of tic40 protein 1 {ECO:0000303|PubMed:28684427};
DE Flags: Precursor;
GN Name=ALB4 {ECO:0000303|PubMed:16595657};
GN Synonyms=ALB {ECO:0000312|EMBL:CAJ45566.1}, ALB3L1 {ECO:0000305},
GN ART1 {ECO:0000305}, STIC1 {ECO:0000303|PubMed:28684427};
GN OrderedLocusNames=At1g24490 {ECO:0000312|Araport:AT1G24490};
GN ORFNames=F21J9.16 {ECO:0000312|EMBL:AAF97961.1}, F21J9_170;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12169665; DOI=10.1073/pnas.172032599;
RA Fulgosi H., Gerdes L., Westphal S., Glockmann C., Soll J.;
RT "Cell and chloroplast division requires ARTEMIS.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:11501-11506(2002).
RN [2]
RP SEQUENCE REVISION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=16595657; DOI=10.1074/jbc.m513623200;
RA Gerdes L., Bals T., Klostermann E., Karl M., Philippar K., Huenken M.,
RA Soll J., Schuenemann D.;
RT "A second thylakoid membrane-localized Alb3/OxaI/YidC homologue is involved
RT in proper chloroplast biogenesis in Arabidopsis thaliana.";
RL J. Biol. Chem. 281:16632-16642(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP FUNCTION.
RX PubMed=19995738; DOI=10.1093/mp/ssp095;
RA Benz M., Bals T., Guegel I.L., Piotrowski M., Kuhn A., Schuenemann D.,
RA Soll J., Ankele E.;
RT "Alb4 of Arabidopsis promotes assembly and stabilization of a non
RT chlorophyll-binding photosynthetic complex, the CF1CF0-ATP synthase.";
RL Mol. Plant 2:1410-1424(2009).
RN [6]
RP FUNCTION, AND INTERACTION WITH ALB3.
RX PubMed=26265777; DOI=10.1104/pp.15.00376;
RA Troesch R., Toepel M., Flores-Perez U., Jarvis P.;
RT "Genetic and physical interaction studies reveal functional similarities
RT between ALBINO3 and ALBINO4 in Arabidopsis.";
RL Plant Physiol. 169:1292-1306(2015).
RN [7]
RP FUNCTION, HOMODIMERIZATION, INTERACTION WITH STIC2, SUBCELLULAR LOCATION,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=28684427; DOI=10.1105/tpc.16.00962;
RA Bedard J., Troesch R., Wu F., Ling Q., Flores-Perez U., Toepel M.,
RA Nawaz F., Jarvis P.;
RT "Suppressors of the chloroplast protein import mutant tic40 reveal a
RT genetic link between protein import and thylakoid biogenesis.";
RL Plant Cell 29:1726-1747(2017).
CC -!- FUNCTION: Required for the insertion of some light harvesting
CC chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid
CC membrane. Plays a role in the accumulation of some cytochrome b6f
CC components in the thylakoid membrane (PubMed:26265777). Required for
CC the assembly and/or stability of the F(1)F(0) ATP synthase in
CC chloroplast thylakoid membranes. Functions to stabilize or promote
CC assembly of F(1) during its attachment to the membrane-embedded F(0)
CC part (PubMed:19995738). Participates with STIC2 in thylakoid protein
CC targeting. May function with a specific subset of thylakoidal proteins
CC (PubMed:28684427). {ECO:0000269|PubMed:19995738,
CC ECO:0000269|PubMed:26265777, ECO:0000269|PubMed:28684427}.
CC -!- SUBUNIT: Homodimer (PubMed:28684427). Interacts with ALB3
CC (PubMed:26265777). Interacts with STIC2 (PubMed:28684427).
CC {ECO:0000269|PubMed:26265777, ECO:0000269|PubMed:28684427}.
CC -!- INTERACTION:
CC Q9FYL3; Q8LBP4: ALB3; NbExp=6; IntAct=EBI-16630560, EBI-1806831;
CC Q9FYL3; O82230: STIC2; NbExp=4; IntAct=EBI-16630560, EBI-4428759;
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000269|PubMed:16595657, ECO:0000269|PubMed:28684427}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9FYL3-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Highly expressed in green tissues.
CC {ECO:0000269|PubMed:16595657}.
CC -!- DISRUPTION PHENOTYPE: No visible macroscopic phenotype under normal
CC growth condtions. Increased number of plastoglobules (lipid bodies) in
CC chloroplasts. {ECO:0000269|PubMed:28684427}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC (TC 2.A.9.2) family.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be the product of one gene (ARTEMIS)
CC that in fact corresponds to two separate genes At1g24485 and At1g24490.
CC {ECO:0000305|PubMed:12169665}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF97961.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AM177312; CAJ45566.1; -; mRNA.
DR EMBL; AC000103; AAF97961.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30539.1; -; Genomic_DNA.
DR PIR; H86378; H86378.
DR RefSeq; NP_173858.5; NM_102294.7. [Q9FYL3-1]
DR AlphaFoldDB; Q9FYL3; -.
DR SMR; Q9FYL3; -.
DR BioGRID; 24303; 5.
DR IntAct; Q9FYL3; 6.
DR STRING; 3702.AT1G24490.1; -.
DR TCDB; 2.A.9.2.2; the membrane protein insertase (yidc/alb3/oxa1) family.
DR PaxDb; Q9FYL3; -.
DR PRIDE; Q9FYL3; -.
DR ProteomicsDB; 245037; -. [Q9FYL3-1]
DR EnsemblPlants; AT1G24490.1; AT1G24490.1; AT1G24490. [Q9FYL3-1]
DR GeneID; 839065; -.
DR Gramene; AT1G24490.1; AT1G24490.1; AT1G24490. [Q9FYL3-1]
DR KEGG; ath:AT1G24490; -.
DR Araport; AT1G24490; -.
DR TAIR; locus:2809836; AT1G24490.
DR eggNOG; KOG1239; Eukaryota.
DR HOGENOM; CLU_036138_7_1_1; -.
DR InParanoid; Q9FYL3; -.
DR OMA; SGITNYM; -.
DR OrthoDB; 1314061at2759; -.
DR PhylomeDB; Q9FYL3; -.
DR PRO; PR:Q9FYL3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FYL3; baseline and differential.
DR Genevisible; Q9FYL3; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009579; C:thylakoid; IDA:TAIR.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0009658; P:chloroplast organization; IMP:TAIR.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0072598; P:protein localization to chloroplast; IGI:TAIR.
DR GO; GO:0010027; P:thylakoid membrane organization; IBA:GO_Central.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chloroplast; Coiled coil; Membrane; Plastid;
KW Reference proteome; Thylakoid; Transit peptide; Transmembrane;
KW Transmembrane helix.
FT TRANSIT 1..45
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 46..499
FT /note="ALBINO3-like protein 1, chloroplastic"
FT /id="PRO_0000020366"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 378..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 397..436
FT /evidence="ECO:0000255"
FT COMPBIAS 378..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 55188 MW; 4AC2A1EE3524FB70 CRC64;
MSSTISLKPT HLILSSFSTG KVLQFRRSRF SHTPSSSSSR YRTLVAQLGF RPDSFDFIKD
HAENLLYTIA DAAVSSSETF ESVAGTTTKT TQSNDWFSGI ANYMETILKV LKDGLSTVHV
PYSYGFAIIL LTVLVKAATF PLTKKQVESA MAMKSLTPQI KAIQERYAGD QEKIQLETAR
LYKLAGINPL AGCLPTLATI PVWIGLYRAL SNVADEGLLT EGFFWIPSLA GPTTVAARQN
GSGISWLFPF IEGHPPLGWP DTLAYLVLPL LLVFSQYLSI QIMQSSQSND PAMKSSQAVT
KLLPLMIGYF ALSVPSGLSL YWLTNNILST AQQVWLQKYG GAKNPVEKFT NLVTKEDKTQ
QIEKSFSEPL VQKSVSELKI PREKGGEKVT PECPKPGERF RLLKEQEAKR RREKEERQKA
EAALSNQNTD KAHEQDEKSD TAIVAEDDKK TELSAVDETS DGTVAVNGKP SIQKDETTNG
TFGIGHDTEQ QHSHETEKR
