ALBA2_SACS2
ID ALBA2_SACS2 Reviewed; 89 AA.
AC Q97ZF4;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=DNA/RNA-binding protein Alba 2;
GN Name=albA2; OrderedLocusNames=SSO6877;
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC -!- FUNCTION: Binds double-stranded DNA tightly but without sequence
CC specificity. It is distributed uniformly and abundantly on the
CC chromosome, suggesting a role in chromatin architecture. However, it
CC does not significantly compact DNA. Binds rRNA and mRNA in vivo. May
CC play a role in maintaining the structural and functional stability of
CC RNA, and, perhaps, ribosomes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- INTERACTION:
CC Q97ZF4; P60849: albA1; NbExp=6; IntAct=EBI-9021196, EBI-9021190;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Chromosome
CC {ECO:0000250}.
CC -!- PTM: Acetylated. Deacetylation by the SIR2-homolog deacetylase may
CC regulate its activity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone-like Alba family. {ECO:0000305}.
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DR EMBL; AE006641; AAK41238.1; -; Genomic_DNA.
DR PIR; G90247; G90247.
DR RefSeq; WP_009992410.1; NC_002754.1.
DR PDB; 1UDV; X-ray; 1.85 A; A/B=1-89.
DR PDB; 2A2Y; NMR; -; A/B=1-89.
DR PDB; 2BKY; X-ray; 1.70 A; X/Y=1-89.
DR PDBsum; 1UDV; -.
DR PDBsum; 2A2Y; -.
DR PDBsum; 2BKY; -.
DR AlphaFoldDB; Q97ZF4; -.
DR BMRB; Q97ZF4; -.
DR SMR; Q97ZF4; -.
DR DIP; DIP-48445N; -.
DR IntAct; Q97ZF4; 1.
DR STRING; 273057.SSO6877; -.
DR EnsemblBacteria; AAK41238; AAK41238; SSO6877.
DR GeneID; 44129895; -.
DR KEGG; sso:SSO6877; -.
DR PATRIC; fig|273057.12.peg.962; -.
DR eggNOG; arCOG01753; Archaea.
DR HOGENOM; CLU_110989_2_0_2; -.
DR InParanoid; Q97ZF4; -.
DR OMA; EVILMFQ; -.
DR PhylomeDB; Q97ZF4; -.
DR EvolutionaryTrace; Q97ZF4; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.110.20; -; 1.
DR HAMAP; MF_01122; AlbA; 1.
DR InterPro; IPR036882; Alba-like_dom_sf.
DR InterPro; IPR013795; DNA/RNA-bd_Alba.
DR InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR Pfam; PF01918; Alba; 1.
DR PIRSF; PIRSF028732; Alba; 1.
DR SUPFAM; SSF82704; SSF82704; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Chromosome; Cytoplasm; DNA-binding;
KW Reference proteome; RNA-binding.
FT CHAIN 1..89
FT /note="DNA/RNA-binding protein Alba 2"
FT /id="PRO_0000151713"
FT MOD_RES 14
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT STRAND 6..9
FT /evidence="ECO:0007829|PDB:2BKY"
FT STRAND 12..14
FT /evidence="ECO:0007829|PDB:1UDV"
FT HELIX 16..28
FT /evidence="ECO:0007829|PDB:2BKY"
FT STRAND 33..39
FT /evidence="ECO:0007829|PDB:2BKY"
FT HELIX 42..57
FT /evidence="ECO:0007829|PDB:2BKY"
FT HELIX 58..60
FT /evidence="ECO:0007829|PDB:2BKY"
FT STRAND 61..73
FT /evidence="ECO:0007829|PDB:2BKY"
FT STRAND 76..87
FT /evidence="ECO:0007829|PDB:2BKY"
SQ SEQUENCE 89 AA; 10239 MW; A945B8C63E8AA02B CRC64;
MTEKLNEIVV RKTKNVEDHV LDVIVLFNQG IDEVILKGTG REISKAVDVY NSLKDRLGDG
VQLVNVQTGS EVRDRRRISY ILLRLKRVY
