ID   ALBA_METTH              Reviewed;          91 AA.
AC   O27527;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=DNA/RNA-binding protein Alba {ECO:0000255|HAMAP-Rule:MF_01122};
GN   Name=albA {ECO:0000255|HAMAP-Rule:MF_01122}; OrderedLocusNames=MTH_1483;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Binds double-stranded DNA tightly but without sequence
CC       specificity. It is distributed uniformly and abundantly on the
CC       chromosome, suggesting a role in chromatin architecture. However, it
CC       does not significantly compact DNA. Binds rRNA and mRNA in vivo. May
CC       play a role in maintaining the structural and functional stability of
CC       RNA, and, perhaps, ribosomes. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01122}.
CC       Chromosome {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- PTM: Acetylated. Deacetylation by the SIR2-homolog deacetylase may
CC       regulate its activity. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SIMILARITY: Belongs to the histone-like Alba family.
CC       {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB85958.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000666; AAB85958.1; ALT_INIT; Genomic_DNA.
DR   PIR; F69064; F69064.
DR   RefSeq; WP_048061063.1; NC_000916.1.
DR   PDB; 3TOE; X-ray; 2.20 A; A/B=1-91.
DR   PDBsum; 3TOE; -.
DR   AlphaFoldDB; O27527; -.
DR   SMR; O27527; -.
DR   STRING; 187420.MTH_1483; -.
DR   EnsemblBacteria; AAB85958; AAB85958; MTH_1483.
DR   GeneID; 1471752; -.
DR   KEGG; mth:MTH_1483; -.
DR   PATRIC; fig|187420.15.peg.1445; -.
DR   HOGENOM; CLU_110989_1_0_2; -.
DR   OMA; QFNEGAK; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.110.20; -; 1.
DR   HAMAP; MF_01122; AlbA; 1.
DR   InterPro; IPR036882; Alba-like_dom_sf.
DR   InterPro; IPR013795; DNA/RNA-bd_Alba.
DR   InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR   Pfam; PF01918; Alba; 1.
DR   PIRSF; PIRSF028732; Alba; 1.
DR   SUPFAM; SSF82704; SSF82704; 1.
DR   TIGRFAMs; TIGR00285; TIGR00285; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Chromosome; Cytoplasm; DNA-binding;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..91
FT                   /note="DNA/RNA-binding protein Alba"
FT                   /id="PRO_0000151702"
FT   MOD_RES         12
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01122"
FT   HELIX           14..26
FT                   /evidence="ECO:0007829|PDB:3TOE"
FT   STRAND          31..37
FT                   /evidence="ECO:0007829|PDB:3TOE"
FT   HELIX           40..54
FT                   /evidence="ECO:0007829|PDB:3TOE"
FT   STRAND          60..72
FT                   /evidence="ECO:0007829|PDB:3TOE"
FT   STRAND          76..89
FT                   /evidence="ECO:0007829|PDB:3TOE"
SQ   SEQUENCE   91 AA;  9975 MW;  0ED292A9463784F6 CRC64;
     MSEENVVYIG NKPVMNYVLA VVTQMNGGTS EVILKARGIA ISRAVDVAEI VRNRFIPDIQ
     IENIDICTEE IIGNEGTATN VSAIEIQLRK D