ALBA_PYRAB
ID ALBA_PYRAB Reviewed; 93 AA.
AC Q9V1N3; G8ZG93;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=DNA/RNA-binding protein Alba {ECO:0000255|HAMAP-Rule:MF_01122};
GN Name=albA {ECO:0000255|HAMAP-Rule:MF_01122}; OrderedLocusNames=PYRAB03940;
GN ORFNames=PAB7094;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- FUNCTION: Binds double-stranded DNA tightly but without sequence
CC specificity. It is distributed uniformly and abundantly on the
CC chromosome, suggesting a role in chromatin architecture. However, it
CC does not significantly compact DNA. Binds rRNA and mRNA in vivo. May
CC play a role in maintaining the structural and functional stability of
CC RNA, and, perhaps, ribosomes. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01122}.
CC Chromosome {ECO:0000255|HAMAP-Rule:MF_01122}.
CC -!- PTM: Acetylated. Deacetylation by the SIR2-homolog deacetylase may
CC regulate its activity. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC -!- SIMILARITY: Belongs to the histone-like Alba family.
CC {ECO:0000255|HAMAP-Rule:MF_01122}.
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DR EMBL; AJ248284; CAB49316.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE69772.1; -; Genomic_DNA.
DR PIR; E75154; E75154.
DR RefSeq; WP_010867516.1; NC_000868.1.
DR AlphaFoldDB; Q9V1N3; -.
DR SMR; Q9V1N3; -.
DR STRING; 272844.PAB7094; -.
DR EnsemblBacteria; CAB49316; CAB49316; PAB7094.
DR GeneID; 1495285; -.
DR KEGG; pab:PAB7094; -.
DR PATRIC; fig|272844.11.peg.415; -.
DR eggNOG; arCOG01753; Archaea.
DR HOGENOM; CLU_110989_1_0_2; -.
DR OMA; QFNEGAK; -.
DR OrthoDB; 111461at2157; -.
DR PhylomeDB; Q9V1N3; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.110.20; -; 1.
DR HAMAP; MF_01122; AlbA; 1.
DR InterPro; IPR036882; Alba-like_dom_sf.
DR InterPro; IPR013795; DNA/RNA-bd_Alba.
DR InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR Pfam; PF01918; Alba; 1.
DR PIRSF; PIRSF028732; Alba; 1.
DR SUPFAM; SSF82704; SSF82704; 1.
DR TIGRFAMs; TIGR00285; TIGR00285; 1.
PE 3: Inferred from homology;
KW Acetylation; Chromosome; Cytoplasm; DNA-binding; RNA-binding.
FT CHAIN 1..93
FT /note="DNA/RNA-binding protein Alba"
FT /id="PRO_0000151704"
FT MOD_RES 12
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01122"
SQ SEQUENCE 93 AA; 10352 MW; CD2D47A30C1566BD CRC64;
MTEEHVVYIG KKPVMNYVLA VITQFHEGAK EVSIKARGRA ISRAVDVAEI VRNRFLKDDV
DVKEIKIGTE ELPTADGRTT NTSTIEIVLA RKA
