FOLH1_HUMAN
ID FOLH1_HUMAN Reviewed; 750 AA.
AC Q04609; A4UU12; A9CB79; B7Z312; B7Z343; D3DQS5; E9PDX8; O43748; Q16305;
AC Q541A4; Q8TAY3; Q9NP15; Q9NYE2; Q9P1P8;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 218.
DE RecName: Full=Glutamate carboxypeptidase 2 {ECO:0000305};
DE EC=3.4.17.21;
DE AltName: Full=Cell growth-inhibiting gene 27 protein;
DE AltName: Full=Folate hydrolase 1;
DE AltName: Full=Folylpoly-gamma-glutamate carboxypeptidase;
DE Short=FGCP;
DE AltName: Full=Glutamate carboxypeptidase II;
DE Short=GCPII;
DE AltName: Full=Membrane glutamate carboxypeptidase;
DE Short=mGCP;
DE AltName: Full=N-acetylated-alpha-linked acidic dipeptidase I;
DE Short=NAALADase I;
DE AltName: Full=Prostate-specific membrane antigen;
DE Short=PSM;
DE Short=PSMA;
DE AltName: Full=Pteroylpoly-gamma-glutamate carboxypeptidase;
GN Name=FOLH1 {ECO:0000312|HGNC:HGNC:3788}; Synonyms=FOLH, NAALAD1, PSM, PSMA;
GN ORFNames=GIG27;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-1), AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Prostatic carcinoma;
RX PubMed=8417812;
RA Israeli R.S., Powell C.T., Fair W.R., Heston W.D.W.;
RT "Molecular cloning of a complementary DNA encoding a prostate-specific
RT membrane antigen.";
RL Cancer Res. 53:227-230(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA').
RC TISSUE=Prostate;
RX PubMed=7882349;
RA Su S.L., Huang I.-P., Fair W.R., Powell C.T., Heston W.D.W.;
RT "Alternatively spliced variants of prostate-specific membrane antigen RNA:
RT ratio of expression as a potential measurement of progression.";
RL Cancer Res. 55:1441-1443(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM PSMA-1), AND VARIANT HIS-75.
RX PubMed=9838072; DOI=10.1016/s0167-4781(98)00200-0;
RA O'Keefe D.S., Su S.L., Bacich D.J., Horiguchi Y., Luo Y., Powell C.T.,
RA Zandvliet D., Russell P.J., Molloy P.L., Nowak N.J., Shows T.B.,
RA Mullins C., Vonder Haar R.A., Fair W.R., Heston W.D.W.;
RT "Mapping, genomic organization and promoter analysis of the human prostate-
RT specific membrane antigen gene.";
RL Biochim. Biophys. Acta 1443:113-127(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-1).
RC TISSUE=Brain;
RX PubMed=9694964;
RA Luthi-Carter R., Barczak A.K., Speno H., Coyle J.T.;
RT "Molecular characterization of human brain N-acetylated alpha-linked acidic
RT dipeptidase (NAALADase).";
RL J. Pharmacol. Exp. Ther. 286:1020-1025(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-1), AND CHARACTERIZATION.
RC TISSUE=Prostate;
RX PubMed=10085079; DOI=10.1074/jbc.274.13.8470;
RA Pangalos M.N., Neefs J.-M., Somers M., Verhasselt P., Bekkers M.,
RA van der Helm L., Fraiponts E., Ashton D., Gordon R.D.;
RT "Isolation and expression of novel human glutamate carboxypeptidases with
RT N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV
RT activity.";
RL J. Biol. Chem. 274:8470-8483(1999).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-1), VARIANT TYR-475, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Jejunum, and Small intestine;
RX PubMed=11092759; DOI=10.1093/hmg/9.19.2837;
RA Devlin A.M., Ling E.-H., Peerson J.M., Fernando S., Clarke R., Smith A.D.,
RA Halsted C.H.;
RT "Glutamate carboxypeptidase II: a polymorphism associated with lower levels
RT of serum folate and hyperhomocysteinemia.";
RL Hum. Mol. Genet. 9:2837-2844(2000).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-1).
RC TISSUE=Prostatic carcinoma;
RA Ye C.Z., Zhang F.L., Zhang Y.K., Chen C.Q.;
RT "Cloning and sequencing of Chinese prostate-specific membrane antigen.";
RL Mian Yi Xue Za Zhi 17:328-330(2001).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-9).
RX PubMed=17929272; DOI=10.1002/pros.20664;
RA Cao K.Y., Mao X.P., Wang D.H., Xu L., Yuan G.Q., Dai S.Q., Zheng B.J.,
RA Qiu S.P.;
RT "High expression of PSM-E correlated with tumor grade in prostate cancer: a
RT new alternatively spliced variant of prostate-specific membrane antigen.";
RL Prostate 67:1791-1800(2007).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Peace D.J., Zhang Y., Holt G., Ferrer K.T., Heller M., Sosman J.A.,
RA Xue B.H.;
RT "Identification of three novel splice variants of prostate-specific
RT membrane antigen.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-8).
RA Kim J.W., Kim H.K., Shin S.M.;
RT "Identification of a cell growth-inhibiting gene.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PSMA-1; PSMA-7 AND 10).
RC TISSUE=Amygdala, Corpus callosum, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [13]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [14]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PSMA-8).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [15]
RP PROTEIN SEQUENCE OF 60-74, AND SUBCELLULAR LOCATION.
RC TISSUE=Prostatic carcinoma;
RX PubMed=9809977;
RA Grauer L.S., Lawler K.D., Marignac J.L., Kumar A., Goel A.S., Wolfert R.L.;
RT "Identification, purification, and subcellular localization of prostate-
RT specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma
RT cell line.";
RL Cancer Res. 58:4787-4789(1998).
RN [16]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 160-750 (ISOFORM PSMA-4), AND NUCLEOTIDE
RP SEQUENCE [MRNA] OF 586-750 (ISOFORM PSMA-3).
RA Lupold S.E., Criley S.C., Coffey D.S.;
RT "Alternative splicing of the prostate-specific membrane antigen.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [17]
RP ALTERNATIVE SPLICING.
RA Bzdega T., She D., Turi T., Wroblewska B., Neale J.H.;
RT "Molecular cloning of alternatively spliced variants of the peptidase
RT against N-acetylaspartylglutamate (NAAG) from human and rat nervous
RT systems.";
RL Abstr. - Soc. Neurosci. 24:579-579(1998).
RN [18]
RP CHARACTERIZATION.
RX PubMed=9622670; DOI=10.1016/s0006-8993(98)00244-3;
RA Luthi-Carter R., Barczak A.K., Speno H.D., Coyle J.T.;
RT "Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned
RT human glutamate carboxypeptidase II.";
RL Brain Res. 795:341-348(1998).
RN [19]
RP DOMAIN STRUCTURE.
RX PubMed=9187245; DOI=10.1016/s0167-4838(97)00008-3;
RA Rawlings N.D., Barrett A.J.;
RT "Structure of membrane glutamate carboxypeptidase.";
RL Biochim. Biophys. Acta 1339:247-252(1997).
RN [20]
RP MUTAGENESIS.
RX PubMed=9882712; DOI=10.1124/mol.55.1.179;
RA Speno H.S., Luthi-Carter R., Macias W.L., Valentine S.L., Joshi A.R.T.,
RA Coyle J.T.;
RT "Site-directed mutagenesis of predicted active site residues in glutamate
RT carboxypeptidase II.";
RL Mol. Pharmacol. 55:179-185(1999).
RN [21]
RP GLYCOSYLATION AT ASN-76; ASN-336; ASN-459; ASN-476 AND ASN-638.
RX PubMed=12754519; DOI=10.1038/nbt827;
RA Zhang H., Li X.-J., Martin D.B., Aebersold R.;
RT "Identification and quantification of N-linked glycoproteins using
RT hydrazide chemistry, stable isotope labeling and mass spectrometry.";
RL Nat. Biotechnol. 21:660-666(2003).
RN [22]
RP GLYCOSYLATION AT ASN-51; ASN-76; ASN-121; ASN-140; ASN-153; ASN-195;
RP ASN-336; ASN-459; ASN-476 AND ASN-638, AND MUTAGENESIS OF ASN-51; ASN-76;
RP ASN-121; ASN-140; ASN-153; ASN-195; ASN-336; ASN-459; ASN-476; ASN-638 AND
RP THR-640.
RX PubMed=15152093; DOI=10.1110/ps.04622104;
RA Barinka C., Sacha P., Sklenar J., Man P., Bezouska K., Slusher B.S.,
RA Konvalinka J.;
RT "Identification of the N-glycosylation sites on glutamate carboxypeptidase
RT II necessary for proteolytic activity.";
RL Protein Sci. 13:1627-1635(2004).
RN [23]
RP TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=14716746; DOI=10.1002/pros.10319;
RA O'Keefe D.S., Bacich D.J., Heston W.D.W.;
RT "Comparative analysis of prostate-specific membrane antigen (PSMA) versus a
RT prostate-specific membrane antigen-like gene.";
RL Prostate 58:200-210(2004).
RN [24]
RP TISSUE SPECIFICITY.
RX PubMed=16555021; DOI=10.1007/s00268-005-0544-5;
RA Kinoshita Y., Kuratsukuri K., Landas S., Imaida K., Rovito P.M. Jr.,
RA Wang C.Y., Haas G.P.;
RT "Expression of prostate-specific membrane antigen in normal and malignant
RT human tissues.";
RL World J. Surg. 30:628-636(2006).
RN [25]
RP TISSUE SPECIFICITY.
RX PubMed=17150306; DOI=10.1016/j.neuroscience.2006.10.022;
RA Sacha P., Zamecnik J., Barinka C., Hlouchova K., Vicha A., Mlcochova P.,
RA Hilgert I., Eckschlager T., Konvalinka J.;
RT "Expression of glutamate carboxypeptidase II in human brain.";
RL Neuroscience 144:1361-1372(2007).
RN [26]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 44-750 IN COMPLEXES WITH
RP GLUTAMATE; INHIBITORS; CALCIUM AND ZINC IONS, COFACTOR, SUBUNIT, AND
RP GLYCOSYLATION AT ASN-76; ASN-121; ASN-140; ASN-195; ASN-459; ASN-476 AND
RP ASN-638.
RX PubMed=16467855; DOI=10.1038/sj.emboj.7600969;
RA Mesters J.R., Barinka C., Li W., Tsukamoto T., Majer P., Slusher B.S.,
RA Konvalinka J., Hilgenfeld R.;
RT "Structure of glutamate carboxypeptidase II, a drug target in neuronal
RT damage and prostate cancer.";
RL EMBO J. 25:1375-1384(2006).
RN [27]
RP X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 44-750 IN COMPLEXES WITH THE
RP INHIBITORS QUISQUALATE AND 2-PMPA; CALCIUM AND ZINC IONS, AND GLYCOSYLATION
RP AT ASN-76; ASN-121; ASN-140; ASN-195; ASN-459; ASN-476 AND ASN-638.
RX PubMed=17372356; DOI=10.1107/s090744490700902x;
RA Mesters J.R., Henning K., Hilgenfeld R.;
RT "Human glutamate carboxypeptidase II inhibition: structures of GCPII in
RT complex with two potent inhibitors, quisqualate and 2-PMPA.";
RL Acta Crystallogr. D 63:508-513(2007).
RN [28]
RP X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 44-750 IN COMPLEXES WITH
RP SUBSTRATE ANALOGS; CALCIUM AND ZINC IONS, ACTIVITY REGULATION, AND
RP GLYCOSYLATION AT ASN-76; ASN-121; ASN-140 ASN-195; ASN-459; ASN-476 AND
RP ASN-638.
RX PubMed=17567119; DOI=10.1021/jm070133w;
RA Barinka C., Rovenska M., Mlcochova P., Hlouchova K., Plechanovova A.,
RA Majer P., Tsukamoto T., Slusher B.S., Konvalinka J., Lubkowski J.;
RT "Structural insight into the pharmacophore pocket of human glutamate
RT carboxypeptidase II.";
RL J. Med. Chem. 50:3267-3273(2007).
RN [29]
RP X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 44-750 IN COMPLEXES WITH
RP UREA-BASED INHIBITORS; CALCIUM AND ZINC IONS, AND GLYCOSYLATION AT ASN-76;
RP ASN-121; ASN-140; ASN-195; ASN-459; ASN-476 AND ASN-638.
RX PubMed=19053759; DOI=10.1021/jm800765e;
RA Barinka C., Byun Y., Dusich C.L., Banerjee S.R., Chen Y., Castanares M.,
RA Kozikowski A.P., Mease R.C., Pomper M.G., Lubkowski J.;
RT "Interactions between human glutamate carboxypeptidase II and urea-based
RT inhibitors: structural characterization.";
RL J. Med. Chem. 51:7737-7743(2008).
RN [30]
RP X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 44-750 IN COMPLEXES WITH SUBSTRATE
RP ANALOGS; CALCIUM AND ZINC IONS, AND GLYCOSYLATION AT ASN-76; ASN-121;
RP ASN-140; ASN-195; ASN-459; ASN-476 AND ASN-638.
RX PubMed=18234225; DOI=10.1016/j.jmb.2007.12.066;
RA Barinka C., Hlouchova K., Rovenska M., Majer P., Dauter M., Hin N.,
RA Ko Y.-S., Tsukamoto T., Slusher B.S., Konvalinka J., Lubkowski J.;
RT "Structural basis of interactions between human glutamate carboxypeptidase
RT II and its substrate analogs.";
RL J. Mol. Biol. 376:1438-1450(2008).
RN [31]
RP X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS) OF 44-750 IN COMPLEX WITH SUBSTRATE;
RP CALCIUM AND ZINC IONS, GLYCOSYLATION AT ASN-76; ASN-121; ASN-140; ASN-195;
RP ASN-459; ASN-476 AND ASN-638, AND MUTAGENESIS OF GLU-424.
RX PubMed=19301871; DOI=10.1021/bi900220s;
RA Klusak V., Barinka C., Plechanovova A., Mlcochova P., Konvalinka J.,
RA Rulisek L., Lubkowski J.;
RT "Reaction mechanism of glutamate carboxypeptidase II revealed by
RT mutagenesis, X-ray crystallography, and computational methods.";
RL Biochemistry 48:4126-4138(2009).
RN [32]
RP VARIANT [LARGE SCALE ANALYSIS] THR-23.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Has both folate hydrolase and N-acetylated-alpha-linked-
CC acidic dipeptidase (NAALADase) activity. Has a preference for tri-
CC alpha-glutamate peptides. In the intestine, required for the uptake of
CC folate. In the brain, modulates excitatory neurotransmission through
CC the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG),
CC thereby releasing glutamate. Involved in prostate tumor progression.
CC -!- FUNCTION: Also exhibits a dipeptidyl-peptidase IV type activity. In
CC vitro, cleaves Gly-Pro-AMC.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an unsubstituted, C-terminal glutamyl residue,
CC typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.;
CC EC=3.4.17.21;
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000269|PubMed:16467855, ECO:0000269|PubMed:17372356,
CC ECO:0000269|PubMed:17567119, ECO:0000269|PubMed:18234225,
CC ECO:0000269|PubMed:19053759, ECO:0000269|PubMed:19301871};
CC Note=Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.
CC {ECO:0000269|PubMed:16467855};
CC -!- ACTIVITY REGULATION: The NAALADase activity is inhibited by beta-NAAG,
CC quisqualic acid, 2-(phosphonomethyl) pentanedioic acid (PMPA) and EDTA.
CC Activated by cobalt. {ECO:0000269|PubMed:17567119}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC pH dependence:
CC Stable at pH greater than 6.5.;
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:16467855,
CC ECO:0000269|PubMed:19301871}.
CC -!- INTERACTION:
CC Q04609-8; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-13060980, EBI-10243654;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9809977};
CC Single-pass type II membrane protein {ECO:0000269|PubMed:9809977}.
CC -!- SUBCELLULAR LOCATION: [Isoform PSMA']: Cytoplasm
CC {ECO:0000269|PubMed:9809977}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=PSMA-1;
CC IsoId=Q04609-1; Sequence=Displayed;
CC Name=PSMA-3;
CC IsoId=Q04609-3; Sequence=VSP_040245;
CC Name=PSMA-4;
CC IsoId=Q04609-4; Sequence=VSP_040243, VSP_040244;
CC Name=PSMA';
CC IsoId=Q04609-6; Sequence=VSP_005336;
CC Name=PSMA-7;
CC IsoId=Q04609-7; Sequence=VSP_038058;
CC Name=PSMA-8;
CC IsoId=Q04609-8; Sequence=VSP_038059;
CC Name=PSMA-9; Synonyms=PSM-E;
CC IsoId=Q04609-9; Sequence=VSP_038058, VSP_038059;
CC Name=10;
CC IsoId=Q04609-10; Sequence=VSP_044287;
CC -!- TISSUE SPECIFICITY: Highly expressed in prostate epithelium. Detected
CC in urinary bladder, kidney, testis, ovary, fallopian tube, breast,
CC adrenal gland, liver, esophagus, stomach, small intestine, colon and
CC brain (at protein level). Detected in the small intestine, brain,
CC kidney, liver, spleen, colon, trachea, spinal cord and the capillary
CC endothelium of a variety of tumors. Expressed specifically in jejunum
CC brush border membranes. In the brain, highly expressed in the ventral
CC striatum and brain stem. Also expressed in fetal liver and kidney.
CC Isoform PSMA' is the most abundant form in normal prostate. Isoform
CC PSMA-1 is the most abundant form in primary prostate tumors. Isoform
CC PSMA-9 is specifically expressed in prostate cancer.
CC {ECO:0000269|PubMed:11092759, ECO:0000269|PubMed:14716746,
CC ECO:0000269|PubMed:16555021, ECO:0000269|PubMed:17150306}.
CC -!- INDUCTION: In the prostate, up-regulated in response to androgen
CC deprivation.
CC -!- DOMAIN: The NAALADase activity is found in the central region, the
CC dipeptidyl peptidase IV type activity in the C-terminal.
CC {ECO:0000269|PubMed:9187245}.
CC -!- PTM: The first two amino acids at the N-terminus of isoform PSMA'
CC appear to be cleaved by limited proteolysis.
CC -!- PTM: The N-terminus is blocked.
CC -!- POLYMORPHISM: Genetic variation in FOLH1 may be associated with low
CC folate levels and consequent hyperhomocysteinemia. This condition can
CC result in increased risk of cardiovascular disease, neural tube
CC defects, and cognitive deficits.
CC -!- MISCELLANEOUS: PSMA is used as a diagnostic and prognostic indicator of
CC prostate cancer, and as a possible marker for various neurological
CC disorders such as schizophrenia, Alzheimer disease and Huntington
CC disease.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF31167.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; M99487; AAA60209.1; -; mRNA.
DR EMBL; S76978; AAB33750.2; -; mRNA.
DR EMBL; AF007544; AAC83972.1; -; Genomic_DNA.
DR EMBL; AF176574; AAD51121.1; -; mRNA.
DR EMBL; EF488811; ABO93402.2; -; mRNA.
DR EMBL; AY101595; AAM34479.1; -; mRNA.
DR EMBL; AF107214; AAF31167.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DQ088979; AAZ66619.1; -; mRNA.
DR EMBL; AK312366; BAG35284.1; -; mRNA.
DR EMBL; AK295368; BAH12048.1; -; mRNA.
DR EMBL; AK295470; BAH12079.1; -; mRNA.
DR EMBL; AC110742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC118273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW67858.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW67861.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW67857.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW67859.1; -; Genomic_DNA.
DR EMBL; BC025672; AAH25672.1; -; mRNA.
DR EMBL; AF254357; AAF71357.1; -; mRNA.
DR EMBL; AF254358; AAF71358.1; -; mRNA.
DR CCDS; CCDS31493.1; -. [Q04609-8]
DR CCDS; CCDS53627.1; -. [Q04609-9]
DR CCDS; CCDS53628.1; -. [Q04609-7]
DR CCDS; CCDS7946.1; -. [Q04609-1]
DR PIR; A56881; A56881.
DR RefSeq; NP_001014986.1; NM_001014986.1. [Q04609-8]
DR RefSeq; NP_001180400.1; NM_001193471.1. [Q04609-7]
DR RefSeq; NP_001180401.1; NM_001193472.1. [Q04609-9]
DR RefSeq; NP_001180402.1; NM_001193473.1. [Q04609-10]
DR RefSeq; NP_004467.1; NM_004476.1. [Q04609-1]
DR RefSeq; XP_016872923.1; XM_017017434.1. [Q04609-7]
DR RefSeq; XP_016872924.1; XM_017017435.1. [Q04609-9]
DR RefSeq; XP_016872925.1; XM_017017436.1.
DR RefSeq; XP_016872926.1; XM_017017437.1.
DR RefSeq; XP_016872931.1; XM_017017442.1.
DR RefSeq; XP_016872932.1; XM_017017443.1.
DR RefSeq; XP_016872933.1; XM_017017444.1. [Q04609-10]
DR RefSeq; XP_016872934.1; XM_017017445.1. [Q04609-10]
DR RefSeq; XP_016872935.1; XM_017017446.1. [Q04609-10]
DR RefSeq; XP_016872936.1; XM_017017447.1. [Q04609-10]
DR RefSeq; XP_016872937.1; XM_017017448.1. [Q04609-10]
DR PDB; 1Z8L; X-ray; 3.50 A; A/B/C/D=56-750.
DR PDB; 2C6C; X-ray; 2.00 A; A=44-750.
DR PDB; 2C6G; X-ray; 2.20 A; A=44-750.
DR PDB; 2C6P; X-ray; 2.39 A; A=44-750.
DR PDB; 2CIJ; X-ray; 2.40 A; A=44-750.
DR PDB; 2JBJ; X-ray; 2.19 A; A=44-750.
DR PDB; 2JBK; X-ray; 2.99 A; A=44-750.
DR PDB; 2OOT; X-ray; 1.64 A; A=44-750.
DR PDB; 2OR4; X-ray; 1.62 A; A=44-750.
DR PDB; 2PVV; X-ray; 2.11 A; A=44-750.
DR PDB; 2PVW; X-ray; 1.71 A; A=44-750.
DR PDB; 2XEF; X-ray; 1.59 A; A=44-750.
DR PDB; 2XEG; X-ray; 1.59 A; A=44-750.
DR PDB; 2XEI; X-ray; 1.69 A; A=44-750.
DR PDB; 2XEJ; X-ray; 1.78 A; A=44-750.
DR PDB; 3BHX; X-ray; 1.60 A; A=44-750.
DR PDB; 3BI0; X-ray; 1.67 A; A=44-750.
DR PDB; 3BI1; X-ray; 1.50 A; A=44-750.
DR PDB; 3BXM; X-ray; 1.71 A; A=44-750.
DR PDB; 3D7D; X-ray; 1.69 A; A=44-750.
DR PDB; 3D7F; X-ray; 1.54 A; A=44-750.
DR PDB; 3D7G; X-ray; 1.75 A; A=44-750.
DR PDB; 3D7H; X-ray; 1.55 A; A=44-750.
DR PDB; 3IWW; X-ray; 2.30 A; A=44-750.
DR PDB; 3RBU; X-ray; 1.60 A; A=44-750.
DR PDB; 3SJE; X-ray; 1.70 A; A=44-750.
DR PDB; 3SJF; X-ray; 1.65 A; A=44-750.
DR PDB; 3SJG; X-ray; 1.65 A; A=44-750.
DR PDB; 3SJX; X-ray; 1.66 A; A=44-750.
DR PDB; 4JYW; X-ray; 1.73 A; A=44-750.
DR PDB; 4JZ0; X-ray; 1.83 A; A=44-750.
DR PDB; 4LQG; X-ray; 1.77 A; A=44-750.
DR PDB; 4MCP; X-ray; 1.65 A; A=44-750.
DR PDB; 4MCQ; X-ray; 2.00 A; A=44-750.
DR PDB; 4MCR; X-ray; 1.65 A; A=44-750.
DR PDB; 4MCS; X-ray; 1.83 A; A=44-750.
DR PDB; 4NGM; X-ray; 1.84 A; A=44-750.
DR PDB; 4NGN; X-ray; 1.64 A; A=44-750.
DR PDB; 4NGP; X-ray; 1.63 A; A=44-750.
DR PDB; 4NGQ; X-ray; 2.08 A; A=44-750.
DR PDB; 4NGR; X-ray; 1.90 A; A=44-750.
DR PDB; 4NGS; X-ray; 1.68 A; A=44-750.
DR PDB; 4NGT; X-ray; 2.31 A; A=44-750.
DR PDB; 4OC0; X-ray; 1.85 A; A=44-750.
DR PDB; 4OC1; X-ray; 1.75 A; A=44-750.
DR PDB; 4OC2; X-ray; 1.65 A; A=44-750.
DR PDB; 4OC3; X-ray; 1.79 A; A=44-750.
DR PDB; 4OC4; X-ray; 1.66 A; A=44-750.
DR PDB; 4OC5; X-ray; 1.70 A; A=44-750.
DR PDB; 4OME; X-ray; 1.79 A; A=44-750.
DR PDB; 4P44; X-ray; 1.75 A; A=44-750.
DR PDB; 4P45; X-ray; 1.87 A; A=44-750.
DR PDB; 4P4B; X-ray; 1.93 A; A=44-750.
DR PDB; 4P4D; X-ray; 1.65 A; A=44-750.
DR PDB; 4P4E; X-ray; 1.67 A; A=44-750.
DR PDB; 4P4F; X-ray; 1.86 A; A=44-750.
DR PDB; 4P4I; X-ray; 1.87 A; A=44-750.
DR PDB; 4P4J; X-ray; 1.66 A; A=44-750.
DR PDB; 4W9Y; X-ray; 1.64 A; A=44-750.
DR PDB; 4X3R; X-ray; 1.86 A; A=44-750.
DR PDB; 5D29; X-ray; 1.80 A; A=56-750.
DR PDB; 5ELY; X-ray; 1.81 A; A=55-750.
DR PDB; 5F09; X-ray; 1.85 A; A=44-750.
DR PDB; 5O5R; X-ray; 1.65 A; A=44-750.
DR PDB; 5O5T; X-ray; 1.43 A; A=44-750.
DR PDB; 5O5U; X-ray; 1.53 A; A=44-750.
DR PDB; 5OF0; X-ray; 1.48 A; A=44-750.
DR PDB; 6ETY; X-ray; 1.68 A; A=44-750.
DR PDB; 6EZ9; X-ray; 1.61 A; A=44-750.
DR PDB; 6F5L; X-ray; 1.63 A; A=44-750.
DR PDB; 6FE5; X-ray; 1.52 A; A=44-750.
DR PDB; 6H7Y; X-ray; 1.81 A; A=44-750.
DR PDB; 6H7Z; X-ray; 2.00 A; A=44-750.
DR PDB; 6HKJ; X-ray; 2.09 A; A=44-750.
DR PDB; 6HKZ; X-ray; 2.09 A; A=44-750.
DR PDB; 6RBC; X-ray; 1.77 A; A=44-750.
DR PDB; 6RTI; X-ray; 2.20 A; A=44-750.
DR PDB; 6S1X; X-ray; 1.76 A; A=44-750.
DR PDB; 6SGP; X-ray; 1.58 A; A=44-750.
DR PDB; 6SKH; X-ray; 1.58 A; A=44-750.
DR PDB; 7BFZ; X-ray; 1.73 A; A=44-750.
DR PDBsum; 1Z8L; -.
DR PDBsum; 2C6C; -.
DR PDBsum; 2C6G; -.
DR PDBsum; 2C6P; -.
DR PDBsum; 2CIJ; -.
DR PDBsum; 2JBJ; -.
DR PDBsum; 2JBK; -.
DR PDBsum; 2OOT; -.
DR PDBsum; 2OR4; -.
DR PDBsum; 2PVV; -.
DR PDBsum; 2PVW; -.
DR PDBsum; 2XEF; -.
DR PDBsum; 2XEG; -.
DR PDBsum; 2XEI; -.
DR PDBsum; 2XEJ; -.
DR PDBsum; 3BHX; -.
DR PDBsum; 3BI0; -.
DR PDBsum; 3BI1; -.
DR PDBsum; 3BXM; -.
DR PDBsum; 3D7D; -.
DR PDBsum; 3D7F; -.
DR PDBsum; 3D7G; -.
DR PDBsum; 3D7H; -.
DR PDBsum; 3IWW; -.
DR PDBsum; 3RBU; -.
DR PDBsum; 3SJE; -.
DR PDBsum; 3SJF; -.
DR PDBsum; 3SJG; -.
DR PDBsum; 3SJX; -.
DR PDBsum; 4JYW; -.
DR PDBsum; 4JZ0; -.
DR PDBsum; 4LQG; -.
DR PDBsum; 4MCP; -.
DR PDBsum; 4MCQ; -.
DR PDBsum; 4MCR; -.
DR PDBsum; 4MCS; -.
DR PDBsum; 4NGM; -.
DR PDBsum; 4NGN; -.
DR PDBsum; 4NGP; -.
DR PDBsum; 4NGQ; -.
DR PDBsum; 4NGR; -.
DR PDBsum; 4NGS; -.
DR PDBsum; 4NGT; -.
DR PDBsum; 4OC0; -.
DR PDBsum; 4OC1; -.
DR PDBsum; 4OC2; -.
DR PDBsum; 4OC3; -.
DR PDBsum; 4OC4; -.
DR PDBsum; 4OC5; -.
DR PDBsum; 4OME; -.
DR PDBsum; 4P44; -.
DR PDBsum; 4P45; -.
DR PDBsum; 4P4B; -.
DR PDBsum; 4P4D; -.
DR PDBsum; 4P4E; -.
DR PDBsum; 4P4F; -.
DR PDBsum; 4P4I; -.
DR PDBsum; 4P4J; -.
DR PDBsum; 4W9Y; -.
DR PDBsum; 4X3R; -.
DR PDBsum; 5D29; -.
DR PDBsum; 5ELY; -.
DR PDBsum; 5F09; -.
DR PDBsum; 5O5R; -.
DR PDBsum; 5O5T; -.
DR PDBsum; 5O5U; -.
DR PDBsum; 5OF0; -.
DR PDBsum; 6ETY; -.
DR PDBsum; 6EZ9; -.
DR PDBsum; 6F5L; -.
DR PDBsum; 6FE5; -.
DR PDBsum; 6H7Y; -.
DR PDBsum; 6H7Z; -.
DR PDBsum; 6HKJ; -.
DR PDBsum; 6HKZ; -.
DR PDBsum; 6RBC; -.
DR PDBsum; 6RTI; -.
DR PDBsum; 6S1X; -.
DR PDBsum; 6SGP; -.
DR PDBsum; 6SKH; -.
DR PDBsum; 7BFZ; -.
DR AlphaFoldDB; Q04609; -.
DR SMR; Q04609; -.
DR BioGRID; 108630; 21.
DR IntAct; Q04609; 7.
DR MINT; Q04609; -.
DR STRING; 9606.ENSP00000256999; -.
DR BindingDB; Q04609; -.
DR ChEMBL; CHEMBL1892; -.
DR DrugBank; DB06928; (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID.
DR DrugBank; DB00089; Capromab pendetide.
DR DrugBank; DB07754; DCFBC.
DR DrugBank; DB00142; Glutamic acid.
DR DrugBank; DB14805; Piflufolastat F 18.
DR DrugBank; DB08835; Spaglumic acid.
DR GuidetoPHARMACOLOGY; 1606; -.
DR MEROPS; M28.010; -.
DR GlyGen; Q04609; 13 sites.
DR iPTMnet; Q04609; -.
DR PhosphoSitePlus; Q04609; -.
DR SwissPalm; Q04609; -.
DR BioMuta; FOLH1; -.
DR DMDM; 548615; -.
DR CPTAC; CPTAC-1491; -.
DR jPOST; Q04609; -.
DR MassIVE; Q04609; -.
DR MaxQB; Q04609; -.
DR PaxDb; Q04609; -.
DR PeptideAtlas; Q04609; -.
DR PRIDE; Q04609; -.
DR ProteomicsDB; 58243; -. [Q04609-1]
DR ProteomicsDB; 58244; -. [Q04609-3]
DR ProteomicsDB; 58245; -. [Q04609-4]
DR ProteomicsDB; 58246; -. [Q04609-6]
DR ProteomicsDB; 58247; -. [Q04609-7]
DR ProteomicsDB; 58248; -. [Q04609-8]
DR ProteomicsDB; 58249; -. [Q04609-9]
DR ProteomicsDB; 6482; -.
DR ABCD; Q04609; 27 sequenced antibodies.
DR Antibodypedia; 2262; 1236 antibodies from 41 providers.
DR DNASU; 2346; -.
DR Ensembl; ENST00000256999.7; ENSP00000256999.2; ENSG00000086205.18. [Q04609-1]
DR Ensembl; ENST00000340334.11; ENSP00000344131.7; ENSG00000086205.18. [Q04609-7]
DR Ensembl; ENST00000356696.7; ENSP00000349129.3; ENSG00000086205.18. [Q04609-8]
DR Ensembl; ENST00000533034.1; ENSP00000431463.1; ENSG00000086205.18. [Q04609-9]
DR GeneID; 2346; -.
DR KEGG; hsa:2346; -.
DR MANE-Select; ENST00000256999.7; ENSP00000256999.2; NM_004476.3; NP_004467.1.
DR UCSC; uc001ngy.3; human. [Q04609-1]
DR CTD; 2346; -.
DR DisGeNET; 2346; -.
DR GeneCards; FOLH1; -.
DR HGNC; HGNC:3788; FOLH1.
DR HPA; ENSG00000086205; Tissue enhanced (intestine, prostate).
DR MIM; 600934; gene.
DR neXtProt; NX_Q04609; -.
DR OpenTargets; ENSG00000086205; -.
DR PharmGKB; PA28205; -.
DR VEuPathDB; HostDB:ENSG00000086205; -.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_3_2_1; -.
DR InParanoid; Q04609; -.
DR OMA; VFAPGIW; -.
DR OrthoDB; 633642at2759; -.
DR PhylomeDB; Q04609; -.
DR TreeFam; TF312981; -.
DR BRENDA; 3.4.17.21; 2681.
DR PathwayCommons; Q04609; -.
DR Reactome; R-HSA-8963693; Aspartate and asparagine metabolism.
DR SignaLink; Q04609; -.
DR BioGRID-ORCS; 2346; 19 hits in 1068 CRISPR screens.
DR ChiTaRS; FOLH1; human.
DR EvolutionaryTrace; Q04609; -.
DR GeneWiki; Glutamate_carboxypeptidase_II; -.
DR GenomeRNAi; 2346; -.
DR Pharos; Q04609; Tclin.
DR PRO; PR:Q04609; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q04609; protein.
DR Bgee; ENSG00000086205; Expressed in duodenum and 101 other tissues.
DR ExpressionAtlas; Q04609; baseline and differential.
DR Genevisible; Q04609; HS.
DR GO; GO:0009986; C:cell surface; IDA:BHF-UCL.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
DR GO; GO:1904492; F:Ac-Asp-Glu binding; IDA:BHF-UCL.
DR GO; GO:0004180; F:carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IDA:BHF-UCL.
DR GO; GO:0008233; F:peptidase activity; NAS:UniProtKB.
DR GO; GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IDA:BHF-UCL.
DR GO; GO:0035609; P:C-terminal protein deglutamylation; IDA:BHF-UCL.
DR GO; GO:0006760; P:folic acid-containing compound metabolic process; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IDA:BHF-UCL.
DR Gene3D; 1.20.930.40; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404; PTHR10404; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF47672; SSF47672; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Calcium; Carboxypeptidase;
KW Cell membrane; Cytoplasm; Dipeptidase; Direct protein sequencing;
KW Glycoprotein; Hydrolase; Membrane; Metal-binding; Metalloprotease;
KW Multifunctional enzyme; Phosphoprotein; Protease; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix; Zinc.
FT CHAIN 1..750
FT /note="Glutamate carboxypeptidase 2"
FT /id="PRO_0000174117"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 20..43
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000305"
FT TOPO_DOM 44..750
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT REGION 274..587
FT /note="NAALADase"
FT ACT_SITE 424
FT /note="Nucleophile; for NAALADase activity"
FT ACT_SITE 628
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 666
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 689
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT BINDING 210
FT /ligand="substrate"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JZ0, ECO:0007744|PDB:4LQG,
FT ECO:0007744|PDB:4MCP, ECO:0007744|PDB:4MCQ,
FT ECO:0007744|PDB:4MCR, ECO:0007744|PDB:4MCS,
FT ECO:0007744|PDB:4NGM, ECO:0007744|PDB:4NGN,
FT ECO:0007744|PDB:4NGP, ECO:0007744|PDB:4NGQ,
FT ECO:0007744|PDB:4NGR, ECO:0007744|PDB:4NGS,
FT ECO:0007744|PDB:4NGT, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 257
FT /ligand="substrate"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 269
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2C6P,
FT ECO:0007744|PDB:2CIJ, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OOT,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVV,
FT ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3BXM, ECO:0007744|PDB:3D7D,
FT ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
FT ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JYW,
FT ECO:0007744|PDB:4JZ0, ECO:0007744|PDB:4LQG,
FT ECO:0007744|PDB:4MCP, ECO:0007744|PDB:4MCQ,
FT ECO:0007744|PDB:4MCR, ECO:0007744|PDB:4MCS,
FT ECO:0007744|PDB:4NGM, ECO:0007744|PDB:4NGN,
FT ECO:0007744|PDB:4NGP, ECO:0007744|PDB:4NGQ,
FT ECO:0007744|PDB:4NGR, ECO:0007744|PDB:4NGS,
FT ECO:0007744|PDB:4NGT, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 272
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2C6P,
FT ECO:0007744|PDB:2CIJ, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OOT,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVV,
FT ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3BXM, ECO:0007744|PDB:3D7D,
FT ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
FT ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JYW,
FT ECO:0007744|PDB:4JZ0, ECO:0007744|PDB:4LQG,
FT ECO:0007744|PDB:4MCP, ECO:0007744|PDB:4MCQ,
FT ECO:0007744|PDB:4MCR, ECO:0007744|PDB:4MCS,
FT ECO:0007744|PDB:4NGM, ECO:0007744|PDB:4NGN,
FT ECO:0007744|PDB:4NGP, ECO:0007744|PDB:4NGQ,
FT ECO:0007744|PDB:4NGR, ECO:0007744|PDB:4NGS,
FT ECO:0007744|PDB:4NGT, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 377
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT BINDING 387
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT BINDING 387
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT BINDING 424
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3Q0"
FT BINDING 425
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT BINDING 433
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2C6P,
FT ECO:0007744|PDB:2CIJ, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OOT,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVV,
FT ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3BXM, ECO:0007744|PDB:3D7D,
FT ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
FT ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JYW,
FT ECO:0007744|PDB:4JZ0, ECO:0007744|PDB:4LQG,
FT ECO:0007744|PDB:4MCP, ECO:0007744|PDB:4MCQ,
FT ECO:0007744|PDB:4MCR, ECO:0007744|PDB:4MCS,
FT ECO:0007744|PDB:4NGM, ECO:0007744|PDB:4NGN,
FT ECO:0007744|PDB:4NGP, ECO:0007744|PDB:4NGQ,
FT ECO:0007744|PDB:4NGR, ECO:0007744|PDB:4NGS,
FT ECO:0007744|PDB:4NGT, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 436
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2C6P,
FT ECO:0007744|PDB:2CIJ, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OOT,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVV,
FT ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3BXM, ECO:0007744|PDB:3D7D,
FT ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
FT ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JYW,
FT ECO:0007744|PDB:4JZ0, ECO:0007744|PDB:4LQG,
FT ECO:0007744|PDB:4MCP, ECO:0007744|PDB:4MCQ,
FT ECO:0007744|PDB:4MCR, ECO:0007744|PDB:4MCS,
FT ECO:0007744|PDB:4NGM, ECO:0007744|PDB:4NGN,
FT ECO:0007744|PDB:4NGP, ECO:0007744|PDB:4NGQ,
FT ECO:0007744|PDB:4NGR, ECO:0007744|PDB:4NGS,
FT ECO:0007744|PDB:4NGT, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 453
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT BINDING 517..518
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3Q0"
FT BINDING 519
FT /ligand="substrate"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT BINDING 534..536
FT /ligand="substrate"
FT /evidence="ECO:0000269|PubMed:18234225,
FT ECO:0000269|PubMed:19053759, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 552..553
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3Q0"
FT BINDING 552
FT /ligand="substrate"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3D7D,
FT ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
FT ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JYW,
FT ECO:0007744|PDB:4JZ0, ECO:0007744|PDB:4LQG,
FT ECO:0007744|PDB:4MCP, ECO:0007744|PDB:4MCQ,
FT ECO:0007744|PDB:4MCR, ECO:0007744|PDB:4MCS,
FT ECO:0007744|PDB:4NGM, ECO:0007744|PDB:4NGN,
FT ECO:0007744|PDB:4NGP, ECO:0007744|PDB:4NGQ,
FT ECO:0007744|PDB:4NGR, ECO:0007744|PDB:4NGS,
FT ECO:0007744|PDB:4NGT, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT BINDING 553
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT BINDING 699..700
FT /ligand="substrate"
FT /evidence="ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3D7D,
FT ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
FT ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJX, ECO:0007744|PDB:4JYW,
FT ECO:0007744|PDB:4JZ0, ECO:0007744|PDB:4LQG,
FT ECO:0007744|PDB:4MCP, ECO:0007744|PDB:4MCQ,
FT ECO:0007744|PDB:4MCR, ECO:0007744|PDB:4MCS,
FT ECO:0007744|PDB:4NGM, ECO:0007744|PDB:4NGN,
FT ECO:0007744|PDB:4NGP, ECO:0007744|PDB:4NGQ,
FT ECO:0007744|PDB:4NGR, ECO:0007744|PDB:4NGS,
FT ECO:0007744|PDB:4NGT, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70627"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15152093"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754519,
FT ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15152093,
FT ECO:0000269|PubMed:16467855, ECO:0000269|PubMed:17372356,
FT ECO:0000269|PubMed:17567119, ECO:0000269|PubMed:18234225,
FT ECO:0000269|PubMed:19053759, ECO:0000269|PubMed:19301871,
FT ECO:0007744|PDB:1Z8L, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15152093,
FT ECO:0000269|PubMed:16467855, ECO:0000269|PubMed:17372356,
FT ECO:0000269|PubMed:17567119, ECO:0000269|PubMed:18234225,
FT ECO:0000269|PubMed:19053759, ECO:0000269|PubMed:19301871,
FT ECO:0007744|PDB:1Z8L, ECO:0007744|PDB:2C6C,
FT ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2C6P,
FT ECO:0007744|PDB:2CIJ, ECO:0007744|PDB:2JBJ,
FT ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OOT,
FT ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVV,
FT ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
FT ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
FT ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
FT ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
FT ECO:0007744|PDB:3BXM, ECO:0007744|PDB:3D7D,
FT ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
FT ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
FT ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJE,
FT ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15152093,
FT ECO:0007744|PDB:1Z8L"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15152093,
FT ECO:0000269|PubMed:16467855, ECO:0000269|PubMed:17372356,
FT ECO:0000269|PubMed:17567119, ECO:0000269|PubMed:18234225,
FT ECO:0000269|PubMed:19053759, ECO:0000269|PubMed:19301871,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4OC0,
FT ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
FT ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
FT ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
FT ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
FT ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
FT ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
FT ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J"
FT CARBOHYD 336
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754519,
FT ECO:0000269|PubMed:15152093"
FT CARBOHYD 459
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754519,
FT ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754519,
FT ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT CARBOHYD 638
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754519,
FT ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
FT ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
FT ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
FT ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
FT ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
FT ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
FT ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
FT ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
FT ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
FT ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
FT ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
FT ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
FT ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
FT ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
FT ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
FT ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
FT ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
FT ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
FT ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
FT ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
FT ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
FT ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
FT ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
FT ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
FT ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
FT ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
FT ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
FT ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
FT ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
FT ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
FT ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
FT ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
FT ECO:0007744|PDB:4P4J"
FT VAR_SEQ 1..308
FT /note="Missing (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044287"
FT VAR_SEQ 1..57
FT /note="Missing (in isoform PSMA')"
FT /evidence="ECO:0000303|PubMed:7882349"
FT /id="VSP_005336"
FT VAR_SEQ 1..39
FT /note="MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLF -> MTAGSSYPL
FT FLAAYACTGCLAERL (in isoform PSMA-7 and isoform PSMA-9)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17929272"
FT /id="VSP_038058"
FT VAR_SEQ 214..243
FT /note="VKNAQLAGAKGVILYSDPADYFAPGVKSYP -> NMLIGVELQRLLVFQVFL
FT FIQLDTMMHRSS (in isoform PSMA-4)"
FT /evidence="ECO:0000305"
FT /id="VSP_040243"
FT VAR_SEQ 244..750
FT /note="Missing (in isoform PSMA-4)"
FT /evidence="ECO:0000305"
FT /id="VSP_040244"
FT VAR_SEQ 657..750
FT /note="NPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGI
FT YDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA -> MSSMLQAATTSMQ
FT GSHSQEFMMLCLILKAKWTLPRPGEK (in isoform PSMA-3)"
FT /evidence="ECO:0000305"
FT /id="VSP_040245"
FT VAR_SEQ 657..688
FT /note="NPIVLRMMNDQLMFLERAFIDPLGLPDRPFYR -> K (in isoform
FT PSMA-8 and isoform PSMA-9)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17929272, ECO:0000303|Ref.10"
FT /id="VSP_038059"
FT VARIANT 23
FT /note="A -> T (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036398"
FT VARIANT 75
FT /note="Y -> H (in dbSNP:rs202676)"
FT /evidence="ECO:0000269|PubMed:9838072"
FT /id="VAR_024592"
FT VARIANT 475
FT /note="H -> Y (can be associated with lower folate and
FT higher homocysteine levels; dbSNP:rs61886492)"
FT /evidence="ECO:0000269|PubMed:11092759"
FT /id="VAR_012736"
FT VARIANT 627
FT /note="V -> L (in dbSNP:rs2988342)"
FT /id="VAR_028882"
FT MUTAGEN 51
FT /note="N->A: Loss of glycosylation. Reduces enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 76
FT /note="N->A: Loss of glycosylation. Reduces enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 121
FT /note="N->A: Loss of glycosylation. Severely reduced enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 140
FT /note="N->A: Loss of glycosylation. Severely reduced enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 153
FT /note="N->A: Loss of glycosylation. Severely reduced enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 195
FT /note="N->A: Loss of glycosylation. Severely reduced enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 336
FT /note="N->A: Loss of glycosylation. Reduces enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 377
FT /note="H->A,G,Q: Complete loss of activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 379
FT /note="D->E,N: Complete loss of activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 387
FT /note="D->E,L: Complete loss of activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 387
FT /note="D->N: No effect on enzyme activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 388
FT /note="P->A: No effect on enzyme activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 424
FT /note="E->A: Complete loss of activity."
FT /evidence="ECO:0000269|PubMed:19301871"
FT MUTAGEN 424
FT /note="E->D: Reduces enzyme activity."
FT /evidence="ECO:0000269|PubMed:19301871"
FT MUTAGEN 424
FT /note="E->Q: Reduces enzyme activity."
FT /evidence="ECO:0000269|PubMed:19301871"
FT MUTAGEN 425
FT /note="E->Q,D: Complete loss of activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 453
FT /note="D->N,L: Complete loss of activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 453
FT /note="D->Q: Reduces enzyme activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 454
FT /note="S->A: Reduces enzyme activity."
FT /evidence="ECO:0000269|PubMed:9882712"
FT MUTAGEN 459
FT /note="N->A: Loss of glycosylation. Reduces enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 476
FT /note="N->A: Loss of glycosylation. Reduces enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 638
FT /note="N->A: Loss of glycosylation. Abolishes enzyme
FT activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT MUTAGEN 640
FT /note="T->A: Abolishes enzyme activity."
FT /evidence="ECO:0000269|PubMed:15152093"
FT CONFLICT 194
FT /note="I -> V (in Ref. 9; AAZ66619)"
FT /evidence="ECO:0000305"
FT CONFLICT 354
FT /note="R -> K (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="I -> N (in Ref. 8; ABO93402)"
FT /evidence="ECO:0000305"
FT HELIX 58..64
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 67..77
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 87..102
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 106..119
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 122..124
FT /evidence="ECO:0007829|PDB:2C6G"
FT STRAND 127..131
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 137..140
FT /evidence="ECO:0007829|PDB:5O5T"
FT TURN 149..151
FT /evidence="ECO:0007829|PDB:3D7H"
FT HELIX 154..156
FT /evidence="ECO:0007829|PDB:3IWW"
FT STRAND 174..176
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 182..190
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 200..204
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 210..219
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 223..228
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 231..234
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 244..247
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 269..272
FT /evidence="ECO:0007829|PDB:1Z8L"
FT HELIX 283..285
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 294..297
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 299..306
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 317..319
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 322..325
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 330..333
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 335..337
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 341..346
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 349..362
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 365..377
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 381..383
FT /evidence="ECO:0007829|PDB:5O5T"
FT TURN 385..388
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 389..407
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 413..422
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 424..426
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 429..437
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 439..445
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 446..451
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 455..457
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 459..466
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 468..470
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 471..479
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 480..482
FT /evidence="ECO:0007829|PDB:5O5T"
FT TURN 486..490
FT /evidence="ECO:0007829|PDB:2JBK"
FT HELIX 493..500
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 504..506
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 507..510
FT /evidence="ECO:0007829|PDB:4NGP"
FT STRAND 517..519
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 521..525
FT /evidence="ECO:0007829|PDB:5O5T"
FT TURN 526..528
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 531..538
FT /evidence="ECO:0007829|PDB:5O5T"
FT TURN 541..543
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 546..548
FT /evidence="ECO:0007829|PDB:5O5T"
FT TURN 550..553
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 559..565
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 571..589
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 597..615
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 619..625
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 630..652
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 658..673
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 684..686
FT /evidence="ECO:0007829|PDB:1Z8L"
FT STRAND 689..695
FT /evidence="ECO:0007829|PDB:5O5T"
FT STRAND 698..705
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 706..712
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 715..717
FT /evidence="ECO:0007829|PDB:5O5T"
FT HELIX 721..744
FT /evidence="ECO:0007829|PDB:5O5T"
SQ SEQUENCE 750 AA; 84331 MW; AD8C0A7DBF47901A CRC64;
MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKA
FLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYP
NKTHPNYISI INEDGNEIFN TSLFEPPPPG YENVSDIVPP FSAFSPQGMP EGDLVYVNYA
RTEDFFKLER DMKINCSGKI VIARYGKVFR GNKVKNAQLA GAKGVILYSD PADYFAPGVK
SYPDGWNLPG GGVQRGNILN LNGAGDPLTP GYPANEYAYR RGIAEAVGLP SIPVHPIGYY
DAQKLLEKMG GSAPPDSSWR GSLKVPYNVG PGFTGNFSTQ KVKMHIHSTN EVTRIYNVIG
TLRGAVEPDR YVILGGHRDS WVFGGIDPQS GAAVVHEIVR SFGTLKKEGW RPRRTILFAS
WDAEEFGLLG STEWAEENSR LLQERGVAYI NADSSIEGNY TLRVDCTPLM YSLVHNLTKE
LKSPDEGFEG KSLYESWTKK SPSPEFSGMP RISKLGSGND FEVFFQRLGI ASGRARYTKN
WETNKFSGYP LYHSVYETYE LVEKFYDPMF KYHLTVAQVR GGMVFELANS IVLPFDCRDY
AVVLRKYADK IYSISMKHPQ EMKTYSVSFD SLFSAVKNFT EIASKFSERL QDFDKSNPIV
LRMMNDQLMF LERAFIDPLG LPDRPFYRHV IYAPSSHNKY AGESFPGIYD ALFDIESKVD
PSKAWGEVKR QIYVAAFTVQ AAAETLSEVA
