ID   ALBA_PYRHO              Reviewed;          93 AA.
AC   O74101;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=DNA/RNA-binding protein Alba {ECO:0000255|HAMAP-Rule:MF_01122};
GN   Name=albA {ECO:0000255|HAMAP-Rule:MF_01122}; OrderedLocusNames=PH1839.1;
GN   ORFNames=PHS053;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Binds double-stranded DNA tightly but without sequence
CC       specificity. It is distributed uniformly and abundantly on the
CC       chromosome, suggesting a role in chromatin architecture. However, it
CC       does not significantly compact DNA. Binds rRNA and mRNA in vivo. May
CC       play a role in maintaining the structural and functional stability of
CC       RNA, and, perhaps, ribosomes. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01122}.
CC       Chromosome {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- PTM: Acetylated. Deacetylation by the SIR2-homolog deacetylase may
CC       regulate its activity. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SIMILARITY: Belongs to the histone-like Alba family.
CC       {ECO:0000255|HAMAP-Rule:MF_01122}.
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DR   EMBL; BA000001; BAA30960.1; -; Genomic_DNA.
DR   PIR; A71196; A71196.
DR   RefSeq; WP_010885899.1; NC_000961.1.
DR   PDB; 2Z7C; X-ray; 2.80 A; A/B/C/D=1-93.
DR   PDBsum; 2Z7C; -.
DR   AlphaFoldDB; O74101; -.
DR   SMR; O74101; -.
DR   MINT; O74101; -.
DR   STRING; 70601.3258277; -.
DR   EnsemblBacteria; BAA30960; BAA30960; BAA30960.
DR   GeneID; 1442681; -.
DR   KEGG; pho:PHS053; -.
DR   eggNOG; arCOG01753; Archaea.
DR   OMA; QFNEGAK; -.
DR   OrthoDB; 111461at2157; -.
DR   EvolutionaryTrace; O74101; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.110.20; -; 1.
DR   HAMAP; MF_01122; AlbA; 1.
DR   InterPro; IPR036882; Alba-like_dom_sf.
DR   InterPro; IPR013795; DNA/RNA-bd_Alba.
DR   InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR   Pfam; PF01918; Alba; 1.
DR   PIRSF; PIRSF028732; Alba; 1.
DR   SUPFAM; SSF82704; SSF82704; 1.
DR   TIGRFAMs; TIGR00285; TIGR00285; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Chromosome; Cytoplasm; DNA-binding; RNA-binding.
FT   CHAIN           1..93
FT                   /note="DNA/RNA-binding protein Alba"
FT                   /id="PRO_0000151707"
FT   MOD_RES         12
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01122"
FT   STRAND          6..8
FT                   /evidence="ECO:0007829|PDB:2Z7C"
FT   HELIX           14..26
FT                   /evidence="ECO:0007829|PDB:2Z7C"
FT   STRAND          30..37
FT                   /evidence="ECO:0007829|PDB:2Z7C"
FT   HELIX           40..54
FT                   /evidence="ECO:0007829|PDB:2Z7C"
FT   STRAND          61..73
FT                   /evidence="ECO:0007829|PDB:2Z7C"
FT   STRAND          79..90
FT                   /evidence="ECO:0007829|PDB:2Z7C"
SQ   SEQUENCE   93 AA;  10382 MW;  D15D47A30C1566BD CRC64;
     MTEEHVVYIG KKPVMNYVLA VITQFHEGAK EVSIKARGRA ISRAVDVAEI VRNRFLKDDV
     DVKEIKIGTE ELPTADGRTT NTSTIEIVLA RKT