FOLR3_HUMAN
ID FOLR3_HUMAN Reviewed; 245 AA.
AC P41439; A0A087WXH3; J3KQ90; Q05C14;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Folate receptor gamma;
DE Short=FR-gamma;
DE AltName: Full=Folate receptor 3;
DE Flags: Precursor;
GN Name=FOLR3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT 107-TYR--SER-245 DEL.
RC TISSUE=Hematopoietic;
RX PubMed=8110752; DOI=10.1021/bi00171a021;
RA Shen F., Ross J.F., Wang X., Ratnam M.;
RT "Identification of a novel folate receptor, a truncated receptor, and
RT receptor type beta in hematopoietic cells: cDNA cloning, expression,
RT immunoreactivity, and tissue specificity.";
RL Biochemistry 33:1209-1215(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP CHARACTERIZATION.
RX PubMed=7727426; DOI=10.1021/bi00016a042;
RA Shen F., Wu M., Ross J.F., Miller D., Ratnam M.;
RT "Folate receptor type gamma is primarily a secretory protein due to lack of
RT an efficient signal for glycosylphosphatidylinositol modification: protein
RT characterization and cell type specificity.";
RL Biochemistry 34:5660-5665(1995).
RN [5]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
CC -!- FUNCTION: Binds to folate and reduced folic acid derivatives and
CC mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
CC Isoform Short does not bind folate.
CC -!- INTERACTION:
CC P41439; X5D778: ANKRD11; NbExp=3; IntAct=EBI-12893875, EBI-17183751;
CC P41439; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-12893875, EBI-741480;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Long;
CC IsoId=P41439-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P41439-4; Sequence=VSP_060090, VSP_060091;
CC -!- TISSUE SPECIFICITY: Spleen, thymus, bone marrow, ovarian carcinoma, and
CC uterine carcinoma.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. Variant in position:
CC 150:MSAHPTWGPGSGRSTRAGAKSAF->ECSPNLGPWIRQVNQSWRKERILNVPLCKEDCERW
CC WEDCRTSYTCKSNWHKGWNWTSGINECPAGALCSTFESYFPTPAALCEGLWSHSFKVSNYSRG.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the folate receptor family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA18381.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAA18382.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA83553.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA83566.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Z32564; CAA83553.1; ALT_INIT; mRNA.
DR EMBL; Z32633; CAA83566.1; ALT_INIT; mRNA.
DR EMBL; U08471; AAA18382.1; ALT_INIT; mRNA.
DR EMBL; U08470; AAA18381.1; ALT_INIT; mRNA.
DR EMBL; AP000812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030285; AAH30285.1; -; mRNA.
DR CCDS; CCDS73344.1; -. [P41439-1]
DR PIR; A53506; A53506.
DR RefSeq; NP_000795.2; NM_000804.3. [P41439-1]
DR RefSeq; NP_001304974.1; NM_001318045.1.
DR AlphaFoldDB; P41439; -.
DR SMR; P41439; -.
DR BioGRID; 108635; 6.
DR IntAct; P41439; 2.
DR STRING; 9606.ENSP00000481114; -.
DR DrugBank; DB00158; Folic acid.
DR DrugBank; DB05168; Vintafolide.
DR GlyGen; P41439; 3 sites.
DR iPTMnet; P41439; -.
DR PhosphoSitePlus; P41439; -.
DR BioMuta; FOLR3; -.
DR DMDM; 1169723; -.
DR jPOST; P41439; -.
DR MassIVE; P41439; -.
DR MaxQB; P41439; -.
DR PeptideAtlas; P41439; -.
DR PRIDE; P41439; -.
DR ProteomicsDB; 55460; -. [P41439-1]
DR Antibodypedia; 30810; 131 antibodies from 22 providers.
DR DNASU; 2352; -.
DR Ensembl; ENST00000611028.3; ENSP00000481114.1; ENSG00000110203.10. [P41439-1]
DR Ensembl; ENST00000612844.4; ENSP00000481027.1; ENSG00000110203.10. [P41439-4]
DR GeneID; 2352; -.
DR KEGG; hsa:2352; -.
DR MANE-Select; ENST00000611028.3; ENSP00000481114.1; NM_000804.4; NP_000795.2.
DR UCSC; uc058ezu.1; human. [P41439-1]
DR CTD; 2352; -.
DR DisGeNET; 2352; -.
DR GeneCards; FOLR3; -.
DR HGNC; HGNC:3795; FOLR3.
DR HPA; ENSG00000110203; Group enriched (bone marrow, lymphoid tissue).
DR MIM; 602469; gene.
DR neXtProt; NX_P41439; -.
DR OpenTargets; ENSG00000110203; -.
DR PharmGKB; PA28211; -.
DR VEuPathDB; HostDB:ENSG00000110203; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183144; -.
DR HOGENOM; CLU_070826_3_0_1; -.
DR InParanoid; P41439; -.
DR OMA; HFIQDGC; -.
DR OrthoDB; 1224404at2759; -.
DR PhylomeDB; P41439; -.
DR PathwayCommons; P41439; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; P41439; -.
DR BioGRID-ORCS; 2352; 13 hits in 285 CRISPR screens.
DR ChiTaRS; FOLR3; human.
DR GenomeRNAi; 2352; -.
DR Pharos; P41439; Tbio.
DR PRO; PR:P41439; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P41439; protein.
DR Bgee; ENSG00000110203; Expressed in granulocyte and 128 other tissues.
DR ExpressionAtlas; P41439; baseline and differential.
DR Genevisible; P41439; HS.
DR GO; GO:0031362; C:anchored component of external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0019898; C:extrinsic component of membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0035580; C:specific granule lumen; TAS:Reactome.
DR GO; GO:1904724; C:tertiary granule lumen; TAS:Reactome.
DR GO; GO:0005542; F:folic acid binding; TAS:ProtInc.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0015884; P:folic acid transport; TAS:ProtInc.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IBA:GO_Central.
DR GO; GO:0035036; P:sperm-egg recognition; IBA:GO_Central.
DR InterPro; IPR004269; Folate_rcpt.
DR InterPro; IPR018143; Folate_rcpt-like.
DR InterPro; IPR032934; FR-gamma.
DR PANTHER; PTHR10517; PTHR10517; 1.
DR PANTHER; PTHR10517:SF17; PTHR10517:SF17; 1.
DR Pfam; PF03024; Folate_rec; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Folate-binding; Glycoprotein;
KW Receptor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..245
FT /note="Folate receptor gamma"
FT /id="PRO_0000008810"
FT BINDING 103
FT /ligand="folate"
FT /ligand_id="ChEBI:CHEBI:62501"
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT BINDING 107
FT /ligand="folate"
FT /ligand_id="ChEBI:CHEBI:62501"
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT BINDING 124..128
FT /ligand="folate"
FT /ligand_id="ChEBI:CHEBI:62501"
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT BINDING 157..162
FT /ligand="folate"
FT /ligand_id="ChEBI:CHEBI:62501"
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT BINDING 196
FT /ligand="folate"
FT /ligand_id="ChEBI:CHEBI:62501"
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 37..65
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 57..105
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 66..109
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 89..175
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 96..146
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 135..209
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 139..189
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT DISULFID 152..169
FT /evidence="ECO:0000250|UniProtKB:P15328"
FT VAR_SEQ 57..172
FT /note="CSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPTCKRHFIQDSCLYE
FT CSPNLGPWIRQVNQSWRKERILNVPLCKEDCERWWEDCRTSYTCKSNWHKGWNWTSGIN
FT ECPAG -> VGAPQGPSPGSVPLDDLPGAEEPEYGGDGCGGERLSPVSSPPSAVPGRRM
FT PAARPAPARSCTRTPPACTTLTGITVVRWNPPASATLSRTAVSMSAHPTWGPGSGRSTR
FT AGAKSAF (in isoform 2)"
FT /id="VSP_060090"
FT VAR_SEQ 173..245
FT /note="Missing (in isoform 2)"
FT /id="VSP_060091"
FT VARIANT 107..245
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:8110752"
FT /id="VAR_081429"
FT CONFLICT 45
FT /note="T -> I (in Ref. 3; AAH30285)"
FT /evidence="ECO:0000305"
FT CONFLICT P41439-4:78
FT /note="E -> V (in Ref. 3; AAH30285)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 27885 MW; 478636F757EC40DB CRC64;
MDMAWQMMQL LLLALVTAAG SAQPRSARAR TDLLNVCMNA KHHKTQPSPE DELYGQCSPW
KKNACCTAST SQELHKDTSR LYNFNWDHCG KMEPTCKRHF IQDSCLYECS PNLGPWIRQV
NQSWRKERIL NVPLCKEDCE RWWEDCRTSY TCKSNWHKGW NWTSGINECP AGALCSTFES
YFPTPAALCE GLWSHSFKVS NYSRGSGRCI QMWFDSAQGN PNEEVAKFYA AAMNAGAPSR
GIIDS
