ID   FOLT2_CAEEL             Reviewed;         424 AA.
AC   O45166;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Folate-like transporter 2;
GN   Name=folt-2; ORFNames=F37B4.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NOMENCLATURE, AND FUNCTION.
RX   PubMed=17475669; DOI=10.1152/ajpcell.00516.2006;
RA   Balamurugan K., Ashokkumar B., Moussaif M., Sze J.Y., Said H.M.;
RT   "Cloning and functional characterization of a folate transporter from the
RT   nematode Caenorhabditis elegans.";
RL   Am. J. Physiol. 293:C670-C681(2007).
CC   -!- FUNCTION: Unlike folt-1, does not appear to act as a folate
CC       transporter. {ECO:0000269|PubMed:17475669}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000305}.
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DR   EMBL; FO080739; CCD66319.1; -; Genomic_DNA.
DR   PIR; A88979; A88979.
DR   RefSeq; NP_503780.1; NM_071379.4.
DR   AlphaFoldDB; O45166; -.
DR   BioGRID; 43802; 3.
DR   DIP; DIP-25852N; -.
DR   STRING; 6239.F37B4.7; -.
DR   EPD; O45166; -.
DR   PaxDb; O45166; -.
DR   PeptideAtlas; O45166; -.
DR   EnsemblMetazoa; F37B4.7.1; F37B4.7.1; WBGene00018138.
DR   GeneID; 178745; -.
DR   KEGG; cel:CELE_F37B4.7; -.
DR   UCSC; F37B4.7; c. elegans.
DR   CTD; 178745; -.
DR   WormBase; F37B4.7; CE17796; WBGene00018138; folt-2.
DR   eggNOG; KOG3810; Eukaryota.
DR   GeneTree; ENSGT00950000183022; -.
DR   HOGENOM; CLU_036909_0_1_1; -.
DR   InParanoid; O45166; -.
DR   OMA; VQVLWKV; -.
DR   OrthoDB; 795242at2759; -.
DR   PhylomeDB; O45166; -.
DR   Reactome; R-CEL-196757; Metabolism of folate and pterines.
DR   Reactome; R-CEL-196819; Vitamin B1 (thiamin) metabolism.
DR   PRO; PR:O45166; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00018138; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005542; F:folic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR028338; ThTr-1.
DR   PANTHER; PTHR10686; PTHR10686; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   PIRSF; PIRSF028739; Folate_carrier; 1.
DR   PIRSF; PIRSF500794; Thiamine_transporter_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00806; rfc; 1.
PE   3: Inferred from homology;
KW   Folate-binding; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..424
FT                   /note="Folate-like transporter 2"
FT                   /id="PRO_0000178666"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        254
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   424 AA;  48964 MW;  87386CE6C5C54878 CRC64;
     MEQWKVMVLI CMYGAVKEFR PTEPYMYEYQ HTVLNMSEQT LNSQVYPIWT YSYLITLIPA
     FLLTDVFLYK PLLVFEAFSY FLCWVIFVFG KSVWSQQVLE VFYGWATATE IAYFAYIYVK
     VPKTEYKSAT AFTRAALLVG RFLAYALAQL LIGLNWTSYS TLNIISLVAM TIAVFLALIL
     PGVEWKEAYE KKLEDNNVQG NLKEIVDQSS YMDYLRMFFV GLRHNLMAIY RNPLILKWSV
     WSALSSCIFY QVTNYTQTLW GTLPESANRY NGITEALVPL LGIPADLITR QLNVNWNRWG
     DLLLAVGSIG QAGLLFWMSQ SHHIVVLYLS YIFYRVIYQL TTTIAQSTLA FSLDSRLFGL
     LFGINTFVAL LLQSILTAVV IDWQKLDIRP QFVVYSCYHL VVAFGFAIIF GIWASRRFFK
     TSTN