ID   FOLT3_CAEEL             Reviewed;         424 AA.
AC   Q22931; A7LPE0;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 3.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Folate-like transporter 3;
GN   Name=folt-3; ORFNames=C50E3.16;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000305}.
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DR   EMBL; FO080913; CCD67752.1; -; Genomic_DNA.
DR   PIR; T29677; T29677.
DR   RefSeq; NP_001041097.2; NM_001047632.2.
DR   AlphaFoldDB; Q22931; -.
DR   STRING; 6239.C50E3.16; -.
DR   PaxDb; Q22931; -.
DR   EnsemblMetazoa; C50E3.16.1; C50E3.16.1; WBGene00044738.
DR   GeneID; 4363081; -.
DR   KEGG; cel:CELE_C50E3.16; -.
DR   UCSC; C50E3.16; c. elegans.
DR   CTD; 4363081; -.
DR   WormBase; C50E3.16; CE45273; WBGene00044738; folt-3.
DR   eggNOG; KOG3810; Eukaryota.
DR   GeneTree; ENSGT00950000183022; -.
DR   HOGENOM; CLU_036909_0_1_1; -.
DR   InParanoid; Q22931; -.
DR   OMA; WADYMTL; -.
DR   OrthoDB; 795242at2759; -.
DR   PhylomeDB; Q22931; -.
DR   Reactome; R-CEL-196757; Metabolism of folate and pterines.
DR   Reactome; R-CEL-196819; Vitamin B1 (thiamin) metabolism.
DR   PRO; PR:Q22931; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00044738; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005542; F:folic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10686; PTHR10686; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   PIRSF; PIRSF028739; Folate_carrier; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00806; rfc; 1.
PE   3: Inferred from homology;
KW   Folate-binding; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..424
FT                   /note="Folate-like transporter 3"
FT                   /id="PRO_0000178665"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        254
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   424 AA;  48974 MW;  FBDE3ACD44D519E6 CRC64;
     MGQWKVMILI CLYGAVKEFR PTEPYMYEYQ HTVLNISEHT LNSEVYPIWT YSYLVALIPS
     FLLTDVLLYK PILIIEALSY FACWMIFVFG RSVWCMQLLE LFYGWATATE IAYFAYIYVK
     VPKEDYKSAT AYTRAALLVG RFLAYTLAQL LIGLNWADYM TLNIINLVSM TFAVFLAAIL
     PHVPWRNAYQ KKLEDKKSVT DLESLVSEAK YSDYLKLFFV ELHQNLYTIY KNPLVLKWSI
     WSALSSCIFY QIINYTQTLW GTLPEKENKY NGIPEALVPL LGIPADLITR QMNVNWNRWG
     DALISVGSLL QAGLLFWMSQ SHEIIILYIC YIIYRVIYQL TTTIAQSTLA LTLDSRLFGL
     LFGINTFVAL ALQSILTAIV IDAEKLAIRA QFVVYSGYHI VVATLFGIIF GIWAIRTIWR
     KRSH