FOLT_LEUMM
ID FOLT_LEUMM Reviewed; 185 AA.
AC Q03ZT0;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Folate transporter FolT;
DE AltName: Full=Folate ECF transporter S component FolT;
GN Name=folT; OrderedLocusNames=LEUM_0142;
OS Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM
OS 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB
OS 8023 / NCTC 12954 / NRRL B-1118 / 37Y).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=203120;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523
RC / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
RN [2]
RP FUNCTION AS A TRANSPORT COMPONENT, SUBUNIT, SUBCELLULAR LOCATION, AND
RP EXPRESSION IN E.COLI.
RC STRAIN=ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523
RC / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y;
RX PubMed=18931129; DOI=10.1128/jb.01208-08;
RA Rodionov D.A., Hebbeln P., Eudes A., ter Beek J., Rodionova I.A.,
RA Erkens G.B., Slotboom D.J., Gelfand M.S., Osterman A.L., Hanson A.D.,
RA Eitinger T.;
RT "A novel class of modular transporters for vitamins in prokaryotes.";
RL J. Bacteriol. 191:42-51(2009).
CC -!- FUNCTION: Folate-binding protein that interacts with the energy-
CC coupling factor (ECF) ABC-transporter complex. Unlike classic ABC
CC transporters this ECF transporter provides the energy necessary to
CC transport a number of different substrates. The substrates themselves
CC are bound by transmembrane, not extracytoplasmic soluble proteins (By
CC similarity). Upon coexpression with EcfA1A2T in E.coli allows 5-
CC formyltetrahydrofolate uptake; uptake requires both FolT and EcfA1A2T.
CC {ECO:0000250, ECO:0000269|PubMed:18931129}.
CC -!- SUBUNIT: In E.coli forms a stable energy-coupling factor (ECF)
CC transporter complex probably composed of a membrane-embedded substrate-
CC binding protein (S component), two ATP-binding proteins (A components)
CC and a transmembrane protein (T component).
CC {ECO:0000269|PubMed:18931129}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:18931129};
CC Multi-pass membrane protein {ECO:0000305|PubMed:18931129}.
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DR EMBL; CP000414; ABJ61292.1; -; Genomic_DNA.
DR RefSeq; WP_011679104.1; NC_008531.1.
DR AlphaFoldDB; Q03ZT0; -.
DR SMR; Q03ZT0; -.
DR STRING; 203120.LEUM_0142; -.
DR EnsemblBacteria; ABJ61292; ABJ61292; LEUM_0142.
DR GeneID; 61177379; -.
DR KEGG; lme:LEUM_0142; -.
DR eggNOG; COG4720; Bacteria.
DR HOGENOM; CLU_098232_3_0_9; -.
DR OMA; WLHIMYG; -.
DR OrthoDB; 1784202at2; -.
DR Proteomes; UP000000362; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005542; F:folic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR030949; ECF_S_folate_fam.
DR InterPro; IPR024529; ECF_trnsprt_substrate-spec.
DR Pfam; PF12822; ECF_trnsprt; 1.
DR TIGRFAMs; TIGR04518; ECF_S_folT_fam; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Folate-binding; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..185
FT /note="Folate transporter FolT"
FT /id="PRO_0000409017"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 185 AA; 20967 MW; B91D533002733A6D CRC64;
MENTTRTWVF PKLDTRQFVL LAMLMALHMV LSRLTVGTNV LQVSFAFVTM SLIAKWYGPL
WSMLIAAILD VIGATIINPG AFFVGFTFTA MISALIYSLA YFKHDKTSWW RVSVAVGLVL
LIANIGLNSI WLVMMYHTAH DWPSFLAFIT PRVIKNLIMF PIQVGISYFL LNNQVISHTT
KKIFS