ID   ALBA_THEKO              Reviewed;          91 AA.
AC   Q5JF39;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=DNA/RNA-binding protein Alba {ECO:0000255|HAMAP-Rule:MF_01122};
GN   Name=albA {ECO:0000255|HAMAP-Rule:MF_01122}; OrderedLocusNames=TK0560;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DNA-BINDING.
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=21148291; DOI=10.1091/mbc.e10-08-0668;
RA   Maruyama H., Shin M., Oda T., Matsumi R., Ohniwa R.L., Itoh T.,
RA   Shirahige K., Imanaka T., Atomi H., Yoshimura S.H., Takeyasu K.;
RT   "Histone and TK0471/TrmBL2 form a novel heterogeneous genome architecture
RT   in the hyperthermophilic archaeon Thermococcus kodakarensis.";
RL   Mol. Biol. Cell 22:386-398(2011).
CC   -!- FUNCTION: Binds double-stranded DNA tightly but without sequence
CC       specificity. It is distributed uniformly and abundantly on the
CC       chromosome, suggesting a role in chromatin architecture. Binds rRNA and
CC       mRNA in vivo. May play a role in maintaining the structural and
CC       functional stability of RNA, and, perhaps, ribosomes (By similarity).
CC       Incubation with DNA in vitro gives fibrous structures 10.3 +/- 1.1 nm
CC       in thickness (naked DNA is 1.83 +/- 0.37 nm). This protein does not
CC       significantly compact DNA (PubMed:21148291). {ECO:0000255|HAMAP-
CC       Rule:MF_01122, ECO:0000269|PubMed:21148291}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01122,
CC       ECO:0000305|PubMed:21148291}. Chromosome {ECO:0000255|HAMAP-
CC       Rule:MF_01122, ECO:0000269|PubMed:21148291}.
CC   -!- PTM: Acetylated. Deacetylation by the SIR2-homolog deacetylase may
CC       regulate its activity. {ECO:0000255|HAMAP-Rule:MF_01122}.
CC   -!- SIMILARITY: Belongs to the histone-like Alba family.
CC       {ECO:0000255|HAMAP-Rule:MF_01122}.
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DR   EMBL; AP006878; BAD84749.1; -; Genomic_DNA.
DR   RefSeq; WP_011249515.1; NC_006624.1.
DR   AlphaFoldDB; Q5JF39; -.
DR   SMR; Q5JF39; -.
DR   STRING; 69014.TK0560; -.
DR   EnsemblBacteria; BAD84749; BAD84749; TK0560.
DR   GeneID; 3235255; -.
DR   KEGG; tko:TK0560; -.
DR   PATRIC; fig|69014.16.peg.547; -.
DR   eggNOG; arCOG01753; Archaea.
DR   HOGENOM; CLU_110989_1_0_2; -.
DR   InParanoid; Q5JF39; -.
DR   OMA; QFNEGAK; -.
DR   OrthoDB; 111461at2157; -.
DR   PhylomeDB; Q5JF39; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   Gene3D; 3.30.110.20; -; 1.
DR   HAMAP; MF_01122; AlbA; 1.
DR   InterPro; IPR036882; Alba-like_dom_sf.
DR   InterPro; IPR013795; DNA/RNA-bd_Alba.
DR   InterPro; IPR002775; DNA/RNA-bd_Alba-like.
DR   Pfam; PF01918; Alba; 1.
DR   PIRSF; PIRSF028732; Alba; 1.
DR   SUPFAM; SSF82704; SSF82704; 1.
DR   TIGRFAMs; TIGR00285; TIGR00285; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Chromosome; Cytoplasm; DNA-binding; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..91
FT                   /note="DNA/RNA-binding protein Alba"
FT                   /id="PRO_0000151708"
FT   MOD_RES         12
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01122"
SQ   SEQUENCE   91 AA;  10148 MW;  2C085DDAEA706A5C CRC64;
     MAEEHVVYIG KKPVMNYVLA VITQFNEGAK EVSIRARGRA ISRAVDVAEI VRNRFLPEVR
     VKEIKIGTEE LPTADGRTAN TSTIEIILEK P