FOSL1_MOUSE
ID FOSL1_MOUSE Reviewed; 273 AA.
AC P48755; O35285;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Fos-related antigen 1;
DE Short=FRA-1;
GN Name=Fosl1; Synonyms=Fra1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cByJ; TISSUE=Spleen;
RX PubMed=8892610;
RA Huo L., Rothstein T.L.;
RT "Isolation and characterization of murine fra-1: induction mediated by CD40
RT and surface Ig is protein kinase C dependent.";
RL J. Immunol. 157:3812-3818(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=9294610; DOI=10.1038/sj.onc.1201460;
RA Schreiber M., Poirier C., Franchi A., Kurzbauer R., Guenet J.-L.,
RA Carle G.F., Wagner E.F.;
RT "Structure and chromosomal assignment of the mouse fra-1 gene, and its
RT exclusion as a candidate gene for oc (osteosclerosis).";
RL Oncogene 15:1171-1178(1997).
RN [3]
RP INTERACTION WITH SMARCB1; SMARCD1; ARID1A AND JUN.
RX PubMed=29272704; DOI=10.1016/j.molcel.2017.11.026;
RA Vierbuchen T., Ling E., Cowley C.J., Couch C.H., Wang X., Harmin D.A.,
RA Roberts C.W.M., Greenberg M.E.;
RT "AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent
RT Enhancer Selection.";
RL Mol. Cell 68:1067-1082.e12(2017).
CC -!- SUBUNIT: Heterodimer (By similarity). Interacts with the BAF
CC multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1
CC (PubMed:29272704). Interacts with ARID1A and JUN (PubMed:29272704).
CC {ECO:0000250|UniProtKB:P47930, ECO:0000269|PubMed:29272704}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P51145}.
CC -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily. {ECO:0000305}.
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DR EMBL; U34245; AAC52888.1; -; mRNA.
DR EMBL; AF017128; AAB71369.1; -; Genomic_DNA.
DR CCDS; CCDS29464.1; -.
DR RefSeq; NP_034365.1; NM_010235.2.
DR AlphaFoldDB; P48755; -.
DR SMR; P48755; -.
DR ELM; P48755; -.
DR STRING; 10090.ENSMUSP00000025850; -.
DR iPTMnet; P48755; -.
DR PhosphoSitePlus; P48755; -.
DR PaxDb; P48755; -.
DR PeptideAtlas; P48755; -.
DR PRIDE; P48755; -.
DR ProteomicsDB; 271711; -.
DR Antibodypedia; 3828; 419 antibodies from 40 providers.
DR DNASU; 14283; -.
DR Ensembl; ENSMUST00000025850; ENSMUSP00000025850; ENSMUSG00000024912.
DR GeneID; 14283; -.
DR KEGG; mmu:14283; -.
DR UCSC; uc008gdc.1; mouse.
DR CTD; 8061; -.
DR MGI; MGI:107179; Fosl1.
DR VEuPathDB; HostDB:ENSMUSG00000024912; -.
DR eggNOG; KOG1414; Eukaryota.
DR GeneTree; ENSGT00940000160034; -.
DR HOGENOM; CLU_049742_2_1_1; -.
DR InParanoid; P48755; -.
DR OMA; LEPADSC; -.
DR OrthoDB; 1221590at2759; -.
DR PhylomeDB; P48755; -.
DR TreeFam; TF326301; -.
DR BioGRID-ORCS; 14283; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Fosl1; mouse.
DR PRO; PR:P48755; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; P48755; protein.
DR Bgee; ENSMUSG00000024912; Expressed in ectoplacental cone and 43 other tissues.
DR ExpressionAtlas; P48755; baseline and differential.
DR Genevisible; P48755; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0042734; C:presynaptic membrane; ISO:MGI.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0031668; P:cellular response to extracellular stimulus; IDA:MGI.
DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0060674; P:placenta blood vessel development; IMP:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISO:MGI.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:2000144; P:positive regulation of DNA-templated transcription, initiation; ISO:MGI.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0051591; P:response to cAMP; IEA:Ensembl.
DR GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR GO; GO:0009629; P:response to gravity; IEA:Ensembl.
DR GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0007296; P:vitellogenesis; IMP:MGI.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR029815; Fra1.
DR PANTHER; PTHR23351; PTHR23351; 1.
DR PANTHER; PTHR23351:SF6; PTHR23351:SF6; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR PRINTS; PR00042; LEUZIPPRFOS.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..273
FT /note="Fos-related antigen 1"
FT /id="PRO_0000076480"
FT DOMAIN 105..168
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..127
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 133..161
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 169..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 267
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P15407"
FT CONFLICT 17
FT /note="P -> A (in Ref. 1; AAC52888)"
FT /evidence="ECO:0000305"
FT CONFLICT 39
FT /note="L -> F (in Ref. 1; AAC52888)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="P -> L (in Ref. 1; AAC52888)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="A -> T (in Ref. 1; AAC52888)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 29800 MW; 4B068B0259866805 CRC64;
MYRDYGEPGP SSGAGSPYGR PAQPPQAQAQ TAQQQKFHLV PSIDSSSQEL HWMVQPHFLG
PTGYPRPLAY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA
KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGDKK
DPGGSGSTSG ASSPPAPGRP VPCISLSPGP VLEPEALHTP TLMTTPSLTP FTPSLVFTYP
STPEPCSSAH RKSSSSSGDP SSDPLGSPTL LAL
