ID   FOSL2_CHICK             Reviewed;         323 AA.
AC   P18625;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Fos-related antigen 2;
DE            Short=FRA-2;
GN   Name=FOSL2; Synonyms=FRA-2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=2110368; DOI=10.1073/pnas.87.9.3619;
RA   Nishina H., Sato H., Suzuki T., Iba H.;
RT   "Isolation and characterization of fra-2, an additional member of the fos
RT   gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:3619-3623(1990).
CC   -!- SUBUNIT: Heterodimer with JUN.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- INDUCTION: Serum inducible, and cycloheximide superinducible.
CC   -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily. {ECO:0000305}.
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DR   EMBL; D10876; BAA01644.1; -; Genomic_DNA.
DR   PIR; A35909; A35909.
DR   RefSeq; NP_001039301.1; NM_001045836.1.
DR   AlphaFoldDB; P18625; -.
DR   SMR; P18625; -.
DR   STRING; 9031.ENSGALP00000016284; -.
DR   PaxDb; P18625; -.
DR   Ensembl; ENSGALT00000016303; ENSGALP00000016284; ENSGALG00000010036.
DR   GeneID; 421416; -.
DR   KEGG; gga:421416; -.
DR   CTD; 2355; -.
DR   VEuPathDB; HostDB:geneid_421416; -.
DR   eggNOG; KOG1414; Eukaryota.
DR   GeneTree; ENSGT00940000158876; -.
DR   InParanoid; P18625; -.
DR   OMA; PNMLEPE; -.
DR   OrthoDB; 1221590at2759; -.
DR   PhylomeDB; P18625; -.
DR   PRO; PR:P18625; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000010036; Expressed in spermatocyte and 14 other tissues.
DR   ExpressionAtlas; P18625; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003334; P:keratinocyte development; IEA:Ensembl.
DR   GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR000837; AP-1.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR029814; Fra2.
DR   PANTHER; PTHR23351; PTHR23351; 1.
DR   PANTHER; PTHR23351:SF25; PTHR23351:SF25; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   PRINTS; PR00042; LEUZIPPRFOS.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA-binding; Nucleus; Proto-oncogene;
KW   Reference proteome.
FT   CHAIN           1..323
FT                   /note="Fos-related antigen 2"
FT                   /id="PRO_0000076482"
FT   DOMAIN          124..187
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..128
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          129..136
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          194..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          288..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..214
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  35242 MW;  E5C2468588F4C3F7 CRC64;
     MYQDYPGSFD TSSRGSSGSP GHPEPYSAGA AQQKFRVDMP GSGSAFIPTI NAITTSQDLQ
     WMVQPTVITS MSSPYSRSHP YSHPLPPLSS VAGHTALQRP GVIKTIGTTV GRRRRDEQLS
     PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEVLE EEKSVLQKEI AELQKEKEKL
     EFMLVAHSPV CKISPEERRS PPTSSLQSVR TGASGAVVVK QEPVEEEIPS SSLVLDKAQR
     SVIKPISIAG GYYGEEALNT PIVVTSTPAI TPGSSNLVFT YPNVLDQESP LSPSESCSKA
     HRRSSSSGDQ SSDSLNSPTL LAL