FOSL_DROMO
ID FOSL_DROMO Reviewed; 784 AA.
AC B4K617;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Transcription factor kayak {ECO:0000250|UniProtKB:P21525};
GN Name=kay {ECO:0000250|UniProtKB:P21525}; ORFNames=GI10426;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1] {ECO:0000312|EMBL:EDW16254.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW16254.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Developmentally regulated transcription factor AP-1 binds and
CC recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role
CC in the function or determination of a particular subset of cells in the
CC developing embryo. It is able to carry out its function either
CC independently of or in conjunction with Jra (By similarity).
CC {ECO:0000250|UniProtKB:P21525}.
CC -!- SUBUNIT: Homodimer. Heterodimer with Jra. The kay-Jra heterodimer binds
CC more stably to the AP-1 site than either of the two proteins alone (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P21525,
CC ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily. {ECO:0000255}.
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DR EMBL; CH933806; EDW16254.1; -; Genomic_DNA.
DR RefSeq; XP_002000793.2; XM_002000757.2.
DR AlphaFoldDB; B4K617; -.
DR SMR; B4K617; -.
DR STRING; 7230.FBpp0159643; -.
DR EnsemblMetazoa; FBtr0428490; FBpp0386028; FBgn0133190.
DR GeneID; 6574764; -.
DR eggNOG; KOG1414; Eukaryota.
DR HOGENOM; CLU_020183_0_0_1; -.
DR InParanoid; B4K617; -.
DR OMA; YQNGHIM; -.
DR OrthoDB; 1378696at2759; -.
DR PhylomeDB; B4K617; -.
DR ChiTaRS; kay; fly.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0035976; C:transcription factor AP-1 complex; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:EnsemblMetazoa.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblMetazoa.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0048674; P:collateral sprouting of injured axon; IEA:EnsemblMetazoa.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007391; P:dorsal closure; IEA:EnsemblMetazoa.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:EnsemblMetazoa.
DR GO; GO:0046529; P:imaginal disc fusion, thorax closure; IEA:EnsemblMetazoa.
DR GO; GO:0045475; P:locomotor rhythm; IEA:EnsemblMetazoa.
DR GO; GO:0007297; P:ovarian follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0061057; P:peptidoglycan recognition protein signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:1903688; P:positive regulation of border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IEA:EnsemblMetazoa.
DR GO; GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0051124; P:synaptic assembly at neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0035220; P:wing disc development; IEA:EnsemblMetazoa.
DR GO; GO:0042060; P:wound healing; IEA:EnsemblMetazoa.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR23351; PTHR23351; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR PRINTS; PR00042; LEUZIPPRFOS.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..784
FT /note="Transcription factor kayak"
FT /id="PRO_0000377386"
FT DOMAIN 459..522
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 97..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..463
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 464..471
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 616..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 594
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21525"
SQ SEQUENCE 784 AA; 85158 MW; C9E7BC2EDFABCEED CRC64;
MMKNLNGRAH NVCYQPYYQQ QLQHQQLHQQ QHQQQQQQQQ QQQHLQQQQL QLQLPYAAQY
NQLQQQQLQY NQQQYYQQQL QQQQQQQQQQ QLLRQQQPTQ SAYQQQNAKQ SYGHNNNNNS
NNNANMARSN MHATTVAAVN ANGNSHANAA NANTATAAMA AMCQMQSFLS QQQQQQRQQQ
QQQQQQYSNN SAHINYNQQQ QQSQQQQQSQ QQQQSQQQQQ SQQQQQQHLP TVATTNGDKL
TLDSANEIAN FLANELFMQQ LVTFDGMQSA PTLTTPTLTP TTLRTIEDTI YELTTDSHVP
FQAGFKPPPL TSLGNITNNN TITSTTAGGA TLPGINANLI NTNPQFDLIA LNCAGSVPGS
DTEESNGSWN EGQLNDDQST TDTSSAATDS TSYQNGGHMM GNGSNGGVNN FAAALSGVNT
SGRGSGLAAN STTSNSATPA RRGGGRRPNK AANMSPEEEE KRRIRRERNK LAAARCRKRR
VDQTNELTEE VDALMKKSED LKKEIESLTA TKSQLEYVLQ THSSTCQKVR DDLLTVATCN
GLIGPTTLLN ACNTSSVSLH NSNNSNNNSN SNDSSNGTIT GFDATLNSTG RSNSPLDLKP
VLIDEQLLQH IKHEPQDGAI DSGSSLDQDG PTPAKRFALP NIATFNASLQ TPTGPAAGAA
LNTPISSTAP SSFAHFSSAI SSPTLNAHAL NKLPKPRPNT LNVNAQRPFG VAAAAGDGKA
PPTQIQGVPI QTPSTGTFNF DSLMDGGTGL TPVSGPLMPT CSSQNKHPLE LPTPTSEPSK
LVSL
