FOSL_DROPS
ID FOSL_DROPS Reviewed; 778 AA.
AC Q29AP1; I5AN93; I5AN94; I5AN95;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Transcription factor kayak {ECO:0000250|UniProtKB:P21525};
GN Name=kay {ECO:0000250|UniProtKB:P21525}; ORFNames=GA13774;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Developmentally regulated transcription factor AP-1 binds and
CC recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role
CC in the function or determination of a particular subset of cells in the
CC developing embryo. It is able to carry out its function either
CC independently of or in conjunction with Jra (By similarity).
CC {ECO:0000250|UniProtKB:P21525}.
CC -!- SUBUNIT: Homodimer. Heterodimer with Jra. The kay-Jra heterodimer binds
CC more stably to the AP-1 site than either of the two proteins alone (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P21525,
CC ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=D;
CC IsoId=Q29AP1-1; Sequence=Displayed;
CC Name=A;
CC IsoId=Q29AP1-2; Sequence=VSP_044219, VSP_044224;
CC Name=B;
CC IsoId=Q29AP1-3; Sequence=VSP_044220, VSP_044223;
CC Name=C;
CC IsoId=Q29AP1-4; Sequence=VSP_044221, VSP_044222;
CC -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily. {ECO:0000255}.
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DR EMBL; CM000070; EAL27308.3; -; Genomic_DNA.
DR EMBL; CM000070; EIM52428.1; -; Genomic_DNA.
DR EMBL; CM000070; EIM52429.1; -; Genomic_DNA.
DR EMBL; CM000070; EIM52430.1; -; Genomic_DNA.
DR AlphaFoldDB; Q29AP1; -.
DR SMR; Q29AP1; -.
DR STRING; 7237.FBpp0297003; -.
DR eggNOG; KOG1414; Eukaryota.
DR InParanoid; Q29AP1; -.
DR OMA; YQNGHIM; -.
DR ChiTaRS; kay; fly.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR23351; PTHR23351; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR PRINTS; PR00042; LEUZIPPRFOS.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator; Alternative splicing; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..778
FT /note="Transcription factor kayak"
FT /id="PRO_0000377388"
FT DOMAIN 457..520
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 24..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..478
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 485..513
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 550..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 588
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..205
FT /note="MMKNLNGRAHNACYHPYLHQLHQAQQLQHQQQQQQQQQQQTQLQQTPHAAHT
FT QQNGLTQNAQPQIQWPYNSSAAANQYYQQQQQQQQQEQQMLRQRQLPTQQPAASYEQQQ
FT QQPQQHQHLQQQQQQHQLRQTFTNAATNTNAAAMAAMCQMQNFFTQQQQQQQQQEFNNN
FT CVHINYNQQQQQQPTAAVATTTPTQKATPTKTTPT -> MIAIKSIEMQHNNNSGSIGG
FT SGNDSHVQQQQQQQMLHQQQQQFQQDFVWANIGNISGSNSPISNSLQLQLQQQQQRSAS
FT WTAECNKQRQITNNNNNMNVNYNQHLTQQQQQQLQQYMQPTYNNYTQLQLQQQQQQPQQ
FT LVPATTSQSNNCYYACQQQQQQQHQQQQHQQQQHQQQQQQQFLAPTTTPSAVAATAIAA
FT TRQVIQRH (in isoform A)"
FT /evidence="ECO:0000305"
FT /id="VSP_044219"
FT VAR_SEQ 1..65
FT /note="MMKNLNGRAHNACYHPYLHQLHQAQQLQHQQQQQQQQQQQTQLQQTPHAAHT
FT QQNGLTQNAQPQI -> MKVKVERKTITKATPTTMSKPKLDEEESEEAAATTEQLDFLP
FT ADLTATTTTIAAATPTTAAAAAA (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_044220"
FT VAR_SEQ 1..25
FT /note="MMKNLNGRAHNACYHPYLHQLHQAQ -> MTLDNYNIFGDEYLFSMPLSPLP
FT KV (in isoform C)"
FT /evidence="ECO:0000305"
FT /id="VSP_044221"
FT VAR_SEQ 26..245
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000305"
FT /id="VSP_044222"
FT VAR_SEQ 66..245
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_044223"
FT VAR_SEQ 206..245
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000305"
FT /id="VSP_044224"
SQ SEQUENCE 778 AA; 84349 MW; 4567DC6D0F278CE0 CRC64;
MMKNLNGRAH NACYHPYLHQ LHQAQQLQHQ QQQQQQQQQQ TQLQQTPHAA HTQQNGLTQN
AQPQIQWPYN SSAAANQYYQ QQQQQQQQEQ QMLRQRQLPT QQPAASYEQQ QQQPQQHQHL
QQQQQQHQLR QTFTNAATNT NAAAMAAMCQ MQNFFTQQQQ QQQQQEFNNN CVHINYNQQQ
QQQPTAAVAT TTPTQKATPT KTTPTNNPTT TTNNSTTTTT TNGDKFAMDA SEIASFLASE
LFMQQLGTFD GIQSAPTLTT PTLTPTTLRS IEETFFEMTN DAPYQAGFKP PPLAPLVNNN
NNNNGNGNGN GNGNGNVLAS SVVPTTTTTA TIIGVSNPLI SQQQQQQQQQ VFDCGASVMP
GSDTEESNGS WADGQMNEDQ SISDTSSGAT DSTSYQNGHM MGNSGGGNGG GTGGANNFSN
VLAAAGRNTN TSNSATPARR GGGRRPNRSA NMTPEEEEKR RIRRERNKQA AARCRKRRVD
QTNELTEEVE LLEKRGENLK KEMELLNETK NQLEYFLQAH RPTCQKVRAD MLSVTTCNGL
IGPPALLSAG SCGSGSSHHN NNSNSNDSSS GTITGLDATL NSTGRSNSPL DLKPVPIDED
LLLHIKDEPL DGALDSSSSL DQDGPPPHKR FALPNIATLM TPTGPAGSLQ TPVSGTAPHG
FGSFPTTISN ISNISSIHNG PTLNSLNKMP KERPNTLAFQ RPFGGQMQLS GSGRAPTQIQ
GVPIQTPSTG TFNFDSLMDG GTGLTPVSGP LIPNCTSQNK HPLELPTPTT EPSKLVSL
