ID   FOS_AVINK               Reviewed;         322 AA.
AC   P23050;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=p55-v-Fos-transforming protein;
GN   Name=V-FOS;
OS   Avian retrovirus NK24.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus;
OC   unclassified Alpharetrovirus.
OX   NCBI_TaxID=11875;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2824811; DOI=10.1128/jvi.61.12.3733-3740.1987;
RA   Nishizawa M., Goto N., Kawai S.;
RT   "An avian transforming retrovirus isolated from a nephroblastoma that
RT   carries the fos gene as the oncogene.";
RL   J. Virol. 61:3733-3740(1987).
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA66158.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M18041; AAA66158.1; ALT_INIT; Genomic_RNA.
DR   PIR; B34071; TVFVF4.
DR   SMR; P23050; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR000837; AP-1.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR029816; c-Fos/v-Fos.
DR   PANTHER; PTHR23351; PTHR23351; 1.
DR   PANTHER; PTHR23351:SF4; PTHR23351:SF4; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   PRINTS; PR00042; LEUZIPPRFOS.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host nucleus; Oncogene; Phosphoprotein.
FT   CHAIN           1..322
FT                   /note="p55-v-Fos-transforming protein"
FT                   /id="PRO_0000076459"
FT   DOMAIN          91..154
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          69..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..113
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          119..147
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          298..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  34334 MW;  4EDD08AAC727DDB2 CRC64;
     SQDFCTDLAV SSANFVPTVT AISTSPDLQW LVQPTLISSV APSQNRGHPY GVPAPAPPAA
     YSRPAVLKAP GGRGQSIGRR GKVEQLSPEE EEKRRIRRER NKMAAAKCRN RRRELTDTLQ
     AETDQLEEEK SALQAEIANL LKEKEKLEFI LAAHRPACKM PEELRFSEEL AAATALDLGA
     PSPAAAEEAF ALPLMTEAPP AVPPKEPSGS GLELKAEPFD ELLFSAGPRE ASRSVPDMDL
     PGASSFYASD WEPLGAGSGG ELEPLCTPVV TCTPCPSTYT STFVFTYPEA DAFPSCAAAH
     RKGSSSNEPS SDSLSSPTLL AL