ALBD_BACSU
ID ALBD_BACSU Reviewed; 436 AA.
AC P71008;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Antilisterial bacteriocin subtilosin biosynthesis protein AlbD;
GN Name=albD; Synonyms=ywhP; OrderedLocusNames=BSU37400;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA Kunst F., Danchin A., Glaser P.;
RT "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT degrees).";
RL Microbiology 143:3313-3328(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RC STRAIN=168 / JH642, and 22a;
RX PubMed=10572140; DOI=10.1128/jb.181.23.7346-7355.1999;
RA Zheng G., Yan L.Z., Vederas J.C., Zuber P.;
RT "Genes of the sbo-alb locus of Bacillus subtilis are required for
RT production of the antilisterial bacteriocin subtilosin.";
RL J. Bacteriol. 181:7346-7355(1999).
RN [4]
RP FUNCTION.
RC STRAIN=168 / JH642;
RX PubMed=10809709; DOI=10.1128/jb.182.11.3266-3273.2000;
RA Zheng G., Hehn R., Zuber P.;
RT "Mutational analysis of the sbo-alb locus of Bacillus subtilis:
RT identification of genes required for subtilosin production and immunity.";
RL J. Bacteriol. 182:3266-3273(2000).
RN [5]
RP TRANSCRIPTIONAL REGULATION.
RC STRAIN=168 / JH642;
RX PubMed=10809710; DOI=10.1128/jb.182.11.3274-3277.2000;
RA Nakano M.M., Zheng G., Zuber P.;
RT "Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of
RT signal transduction under anaerobic conditions in Bacillus subtilis.";
RL J. Bacteriol. 182:3274-3277(2000).
CC -!- FUNCTION: Involved in the production of the bacteriocin subtilosin.
CC Required for immunity to subtilosin. {ECO:0000269|PubMed:10572140,
CC ECO:0000269|PubMed:10809709}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Transcription is highly induced by oxygen limitation and is
CC under dual and independent control of Spo0A-AbrB and ResDE.
CC {ECO:0000269|PubMed:10809710}.
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DR EMBL; Z80360; CAB02506.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15767.1; -; Genomic_DNA.
DR PIR; G70058; G70058.
DR RefSeq; NP_391620.1; NC_000964.3.
DR RefSeq; WP_003243158.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P71008; -.
DR STRING; 224308.BSU37400; -.
DR PaxDb; P71008; -.
DR EnsemblBacteria; CAB15767; CAB15767; BSU_37400.
DR GeneID; 937053; -.
DR KEGG; bsu:BSU37400; -.
DR PATRIC; fig|224308.179.peg.4050; -.
DR eggNOG; COG0474; Bacteria.
DR OMA; RTMFWAK; -.
DR BioCyc; BSUB:BSU37400-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030152; P:bacteriocin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0030153; P:bacteriocin immunity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Antibiotic biosynthesis; Bacteriocin biosynthesis; Bacteriocin immunity;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..436
FT /note="Antilisterial bacteriocin subtilosin biosynthesis
FT protein AlbD"
FT /id="PRO_0000064544"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 436 AA; 49517 MW; FC47D578044F79ED CRC64;
MNNIIPIMSL LFKQLYSRQG KKDAIRIAAG LVILAVFEIG LIRQAGIDES VLRKTYIILA
LLLMNTYMVF LSVTSQWKES YMKLSCLLPI SSRSFWLAQS VVLFVDTCLR RTLFFFILPL
FLFGNGTLSG AQTLFWLGRF SFFTVYSIIF GVVLSNHFVK KKNLMFLLHA AIFACVCISA
ALMPAATIPL CAVHILWAVV IDFPVFLQAP PQQGKMHSFM RRSEFSFYKR EWNRFISSKA
MLLNYAVMAV FSGFFSFQMM NTGIFNQQVI YIVISALLLI CSPIALLYSI EKNDRMLLIT
LPIKRKTMFW AKYRFYSGLL AGGFLLVVMI VGFISGRSIS VLTFLQCIEL LLAGAYIRLT
ADEKRPSFSW QTEQQLWSGF SKYRSYLFCL PLFLAILAGT AVSLAVIPIA GLVIVYYLQK
QDGGFFDTSK RERLGS
