ID   FOXA1_XENTR             Reviewed;         428 AA.
AC   Q8AWH1;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Forkhead box protein A1;
DE            Short=FoxA1;
DE   AltName: Full=tFoxA1;
GN   Name=foxa1 {ECO:0000250|UniProtKB:Q6LD29};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAN76331.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Neurula {ECO:0000269|PubMed:12508233};
RX   PubMed=12508233; DOI=10.1002/dvdy.10201;
RA   D'Souza A., Lee M., Taverner N., Mason J., Carruthers S., Smith J.C.,
RA   Amaya E., Papalopulu N., Zorn A.M.;
RT   "Molecular components of the endoderm specification pathway in Xenopus
RT   tropicalis.";
RL   Dev. Dyn. 226:118-127(2003).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000269|PubMed:12508233}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the endoderm of mid-gastrula embryos.
CC       At neurula stage, expressed in the notochord and in ciliated cells of
CC       the epithelium. During tailbud stages, expressed throughout the
CC       endoderm as well as in the notochord and neural floor plate.
CC       {ECO:0000269|PubMed:12508233}.
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DR   EMBL; AY157637; AAN76331.1; -; mRNA.
DR   RefSeq; NP_989419.1; NM_204088.1.
DR   AlphaFoldDB; Q8AWH1; -.
DR   SMR; Q8AWH1; -.
DR   STRING; 8364.ENSXETP00000026943; -.
DR   PaxDb; Q8AWH1; -.
DR   GeneID; 395059; -.
DR   KEGG; xtr:395059; -.
DR   CTD; 3169; -.
DR   eggNOG; KOG3563; Eukaryota.
DR   InParanoid; Q8AWH1; -.
DR   OrthoDB; 1181467at2759; -.
DR   Reactome; R-XTR-9018519; Estrogen-dependent gene expression.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025867; Expressed in neurula embryo and 36 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR013638; Fork-head_N.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018533; Forkhead_box_C.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF08430; Forkhead_N; 1.
DR   Pfam; PF09354; HNF_C; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..428
FT                   /note="Forkhead box protein A1"
FT                   /id="PRO_0000248855"
FT   DNA_BIND        158..252
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          257..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  46606 MW;  657A3A37A99B77DE CRC64;
     MLGIVKMEGH ETTDWSNYYQ DTQEAYSSVP VSNMTQGLAS MNTYMTMNPM SSSSNMTAGS
     FNMSYANSGL GAGLSPSGMS GMGAGSASAM NGMGSGVSSM GTALSPSSMN AMSAQQASIN
     SLSYSGMNPG MSPMAYGPSN MNRTRDTKTF RRSYPHAKPP YSYISLITMA IQQAPSKMLT
     LSEIYQWIMD LFLYYRQNQQ RWQNSIRHSL SFNDCFVKVA RSPDKPGKGS YWTLHPDSGN
     MFENGCYLRR QKRFKCEKQQ GGKGSQDGRK DVSGPSSPLH RVHGKSSQMD SSSSMSNPSS
     SPQSLEHNGS NGEMKPQVAA GPSPLSSHQN HSTHSLAHET HIHLKGDPHY SFNHPFSINN
     LMSSSEQQHK LDFKAYEQAL QQYSSYSGGL PGMPLGSPSM AGRGSIEPSA LEPTYYQGVY
     SRPVLNTS