ID   FOXA2_DANRE             Reviewed;         409 AA.
AC   Q07342;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Forkhead box protein A2;
DE   AltName: Full=Axial protein;
GN   Name=foxa2; Synonyms=axial;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7687227; DOI=10.1101/gad.7.7b.1436;
RA   Straehle U., Blader P., Henrique D., Ingham P.W.;
RT   "Axial, a zebrafish gene expressed along the developing body axis, shows
RT   altered expression in cyclops mutant embryos.";
RL   Genes Dev. 7:1436-1446(1993).
CC   -!- FUNCTION: May play a crucial role in specification of both the axial
CC       mesendoderm and the ventral nervous system.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed just before gastrulation in a narrow
CC       region on the dorsal side of the embryo. Expression can be detected in
CC       the involuted cells comprising the mesendoderm of the developing axis.
CC       At the end of gastrulation expression is turned on in the ventral
CC       neural plate in cells adjacent to the axial-expressing mesodermal
CC       cells.
CC   -!- INDUCTION: By mesoderm-inducing factor activin A.
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DR   EMBL; Z22762; CAA80443.1; -; mRNA.
DR   PIR; A47527; A47527.
DR   RefSeq; NP_571024.1; NM_130949.2.
DR   AlphaFoldDB; Q07342; -.
DR   SMR; Q07342; -.
DR   STRING; 7955.ENSDARP00000007827; -.
DR   PaxDb; Q07342; -.
DR   GeneID; 30126; -.
DR   KEGG; dre:30126; -.
DR   CTD; 3170; -.
DR   ZFIN; ZDB-GENE-980526-404; foxa2.
DR   eggNOG; KOG3563; Eukaryota.
DR   InParanoid; Q07342; -.
DR   OrthoDB; 1181467at2759; -.
DR   PRO; PR:Q07342; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:ZFIN.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0048319; P:axial mesoderm morphogenesis; IGI:ZFIN.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0032289; P:central nervous system myelin formation; IMP:ZFIN.
DR   GO; GO:0007492; P:endoderm development; IMP:ZFIN.
DR   GO; GO:0033504; P:floor plate development; IMP:ZFIN.
DR   GO; GO:0021779; P:oligodendrocyte cell fate commitment; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007418; P:ventral midline development; IMP:ZFIN.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR013638; Fork-head_N.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018533; Forkhead_box_C.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF08430; Forkhead_N; 1.
DR   Pfam; PF09354; HNF_C; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..409
FT                   /note="Forkhead box protein A2"
FT                   /id="PRO_0000091895"
FT   DNA_BIND        150..241
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          250..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  45076 MW;  3ABB5B1D7B37071A CRC64;
     MLGAVKMEGH EHAADWSTYY GEPECYTSVS NMNTGLGMNS MNTYMTMSGM SSTANMTAAN
     TMNMSYVNTG MSPSMTGMSP GTGAMAGMGA GMTGMSAALS PTMSPMAAQA PSMNALTSYS
     NMNAMSPMYG QSNINRSRDP KTYRRSYTHA KPPYSYISLI TMAIQQSPSK MLTLSEIYQW
     IMDLFPFYRQ NQQRWQNSIR HSLSFNDCFL KVPRSPDKPG KGSFWTLHPD SGNMFENGCY
     LRRQKRFKCD KKLSKDPSRK TSEGGSNSSS ESCNGNESPH SNSSSNELKR SLSDMKSGQG
     LSPDHAASPT SQAQHLLAQH HSVLAHEGHL KPEHHYSFNH PFSINNLMSS EQQHHKMDLK
     TYEQVMHYGY GSPMAGTLSM GSMASKAGLD SPDTSYYQGV YSRPILNSS