ID   ALBE_BACSU              Reviewed;         386 AA.
AC   P71007;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Antilisterial bacteriocin subtilosin biosynthesis protein AlbE;
GN   Name=albE; Synonyms=ywhO; OrderedLocusNames=BSU37410;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA   Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA   Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA   Kunst F., Danchin A., Glaser P.;
RT   "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT   degrees).";
RL   Microbiology 143:3313-3328(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RC   STRAIN=168 / JH642, and 22a;
RX   PubMed=10572140; DOI=10.1128/jb.181.23.7346-7355.1999;
RA   Zheng G., Yan L.Z., Vederas J.C., Zuber P.;
RT   "Genes of the sbo-alb locus of Bacillus subtilis are required for
RT   production of the antilisterial bacteriocin subtilosin.";
RL   J. Bacteriol. 181:7346-7355(1999).
RN   [4]
RP   FUNCTION.
RC   STRAIN=168 / JH642;
RX   PubMed=10809709; DOI=10.1128/jb.182.11.3266-3273.2000;
RA   Zheng G., Hehn R., Zuber P.;
RT   "Mutational analysis of the sbo-alb locus of Bacillus subtilis:
RT   identification of genes required for subtilosin production and immunity.";
RL   J. Bacteriol. 182:3266-3273(2000).
RN   [5]
RP   TRANSCRIPTIONAL REGULATION.
RC   STRAIN=168 / JH642;
RX   PubMed=10809710; DOI=10.1128/jb.182.11.3274-3277.2000;
RA   Nakano M.M., Zheng G., Zuber P.;
RT   "Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of
RT   signal transduction under anaerobic conditions in Bacillus subtilis.";
RL   J. Bacteriol. 182:3274-3277(2000).
CC   -!- FUNCTION: Involved in the production of the bacteriocin subtilosin.
CC       {ECO:0000269|PubMed:10572140, ECO:0000269|PubMed:10809709}.
CC   -!- INDUCTION: Transcription is highly induced by oxygen limitation and is
CC       under dual and independent control of Spo0A-AbrB and ResDE.
CC       {ECO:0000269|PubMed:10809710}.
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DR   EMBL; Z80360; CAB02505.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15768.1; -; Genomic_DNA.
DR   PIR; F70058; F70058.
DR   RefSeq; NP_391621.1; NC_000964.3.
DR   RefSeq; WP_010886633.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P71007; -.
DR   SMR; P71007; -.
DR   STRING; 224308.BSU37410; -.
DR   PaxDb; P71007; -.
DR   EnsemblBacteria; CAB15768; CAB15768; BSU_37410.
DR   GeneID; 938514; -.
DR   KEGG; bsu:BSU37410; -.
DR   PATRIC; fig|224308.43.peg.3921; -.
DR   eggNOG; COG0612; Bacteria.
DR   OMA; HVITRYD; -.
DR   PhylomeDB; P71007; -.
DR   BioCyc; BSUB:BSU37410-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0030152; P:bacteriocin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; SSF63411; 2.
PE   2: Evidence at transcript level;
KW   Antibiotic biosynthesis; Bacteriocin biosynthesis; Reference proteome.
FT   CHAIN           1..386
FT                   /note="Antilisterial bacteriocin subtilosin biosynthesis
FT                   protein AlbE"
FT                   /id="PRO_0000064546"
SQ   SEQUENCE   386 AA;  43361 MW;  B5BB1E8514F2B916 CRC64;
     MEVNLLKTHQ FSTISIAASF LKPIESAAEP EEETIYFYGA AAYLKEQIID AFGYAAGSRF
     MYSANLFFDQ QLKTCGTRLI HPLYNGNLHV DALMKTFADL SFPSSLSFEA FEKARNELLL
     KIEKKFTDPF SYSAARLAEE VFGNPMYGTG MFGRRDRIKA IHPKRFLDAT DFIVDLVSQQ
     KQLNILGQVQ ACDVRGHAPQ TSAVTSGRIP VNRHVFETET RSAAGPSVLT LGFDCGEMKD
     ASDYIKIQLI DGLLGKYGHS ALFKHFREKD LAVYHVITRY DVMNNLLLVS ICTDQLHEKD
     IPPRVLEAVS AFHTDERELE QAKQFLRNEL LLQFDSPEGL LAYMGVLRRF SCTKEALLDG
     ISAVTCRDVL QFIATINYIG AHVVRG