ID   FOXA2_ORYLA             Reviewed;         415 AA.
AC   O42097;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Hepatocyte nuclear factor 3-beta;
DE            Short=HNF-3-beta;
DE            Short=HNF-3B;
DE   AltName: Full=Forkhead box protein A2;
DE   AltName: Full=Me-HNF3B;
GN   Name=foxa2; Synonyms=hnf3b;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Orange-red;
RA   Okamoto H.M., Nakayama I., Nagoya H., Araki K.;
RT   "Predicted protein structure of medaka FoxA3 and its expression in
RT   polster.";
RL   Zool. Sci. 18:823-832(2001).
CC   -!- FUNCTION: Transcription activator for a number of liver genes.
CC       Interacts with the cis-acting regulatory regions of these genes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; AB001572; BAA23579.1; -; mRNA.
DR   RefSeq; NP_001098162.1; NM_001104692.1.
DR   AlphaFoldDB; O42097; -.
DR   SMR; O42097; -.
DR   STRING; 8090.ENSORLP00000021768; -.
DR   Ensembl; ENSORLT00000021769; ENSORLP00000021768; ENSORLG00000017407.
DR   GeneID; 100049256; -.
DR   KEGG; ola:100049256; -.
DR   CTD; 3170; -.
DR   eggNOG; KOG3563; Eukaryota.
DR   GeneTree; ENSGT00940000155999; -.
DR   InParanoid; O42097; -.
DR   OrthoDB; 1181467at2759; -.
DR   Proteomes; UP000001038; Chromosome 22.
DR   Proteomes; UP000265180; Unplaced.
DR   Proteomes; UP000265200; Unplaced.
DR   Bgee; ENSORLG00000017407; Expressed in liver and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR013638; Fork-head_N.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018533; Forkhead_box_C.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF08430; Forkhead_N; 1.
DR   Pfam; PF09354; HNF_C; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..415
FT                   /note="Hepatocyte nuclear factor 3-beta"
FT                   /id="PRO_0000091798"
FT   DNA_BIND        150..244
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          251..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  45722 MW;  CB85A0C2A20FF52A CRC64;
     MMLGAVKMEG HEHTDWSTYY GEPECYTSVG NMNTGLGMNS MNTYMSMSGM STTANMTANS
     MNMSYVNTGM SPSMTGMSPG TGAMNGMGAG MTAMSTALSP SMSPMTGQPG SMNALTSYTN
     MNAMSPIYGQ SNINRSRDPK TYRRSYTHAK PPYSYISLIT MAIQQSPSKM LTLAEIYQWI
     MDLFPFYRQN QQRWQNSIRH SLSFNDCFLK VPRSPDKPGK GSFWTLHPDS GNMFENGCYL
     RRQKRFKCEK KMSMKEPGRK GGDGGSANSS SDSCNGNESP HSNSSSGEHK RSLSDMKGSQ
     ALSPEHTAPS PVSQGQHLMS QHHSVLAHEA HLKPEHHYSF NHPFSINNLM SSEQQHHKMD
     LKTYEQVMHY SGYGSPMTGA LSMGSMAGKA GLDSASIPDT SYYQGVYSRP IMNSS