ID   FOXA2_XENTR             Reviewed;         434 AA.
AC   Q7T1R4; Q5I088;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Forkhead box protein A2;
DE            Short=FoxA2;
GN   Name=foxa2 {ECO:0000312|EMBL:CAJ82886.1}; ORFNames=TNeu069i04.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAP82293.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:AAP82293.1};
RX   PubMed=12508233; DOI=10.1002/dvdy.10201;
RA   D'Souza A., Lee M., Taverner N., Mason J., Carruthers S., Smith J.C.,
RA   Amaya E., Papalopulu N., Zorn A.M.;
RT   "Molecular components of the endoderm specification pathway in Xenopus
RT   tropicalis.";
RL   Dev. Dyn. 226:118-127(2003).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:CAJ82886.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:CAJ82886.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305, ECO:0000312|EMBL:CAJ82886.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-434.
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH88590.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional activator during early development,
CC       limiting the extent of mesoderm formation in the gastrula. Binds to DNA
CC       via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the
CC       preferred binding site (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR   EMBL; AY260736; AAP82293.1; -; mRNA.
DR   EMBL; CR848398; CAJ82886.1; -; mRNA.
DR   EMBL; BC088590; AAH88590.1; -; mRNA.
DR   RefSeq; NP_989423.1; NM_204092.1.
DR   AlphaFoldDB; Q7T1R4; -.
DR   SMR; Q7T1R4; -.
DR   STRING; 8364.ENSXETP00000013505; -.
DR   PaxDb; Q7T1R4; -.
DR   Ensembl; ENSXETT00000056642; ENSXETP00000056642; ENSXETG00000026998.
DR   GeneID; 395063; -.
DR   KEGG; xtr:395063; -.
DR   CTD; 3170; -.
DR   Xenbase; XB-GENE-480476; foxa2.
DR   eggNOG; KOG3563; Eukaryota.
DR   InParanoid; Q7T1R4; -.
DR   OMA; SESAYYH; -.
DR   OrthoDB; 1181467at2759; -.
DR   PhylomeDB; Q7T1R4; -.
DR   TreeFam; TF316127; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026998; Expressed in neurula embryo and 11 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR013638; Fork-head_N.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018533; Forkhead_box_C.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF08430; Forkhead_N; 1.
DR   Pfam; PF09354; HNF_C; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..434
FT                   /note="Forkhead box protein A2"
FT                   /id="PRO_0000248858"
FT   DNA_BIND        149..243
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          249..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  47865 MW;  7CE365B2FD6A2913 CRC64;
     MLGAVKMEGH EATDWSSYYG EPEAYSSVGN MNAGLSMNPM NTYMSMSAMS TSANMTAGSM
     NMSYVNTGMS PSLTGMSPGT GAMTGMGTGV ASMASHLSPS MSPMSAQATS MNALAPYTNM
     NSMSPIYGQS NINRSRDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM
     DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR
     RQKRFKCEKK PSLREGGGKK LSEGSSSVGS AANSSSESSV GNESPHSSSS PCQEQKRSLV
     DMKSSQGLSP DHAASPASQA QHLLSQHHSV LSHEAQSHLK PEHHYSFNHP FSINNLMSSE
     QQHHHHHHHN HHHHHKMDLK AYEQVMHYSG YGSPMTGSLA MSTVTNKSGL ESSPISSDTS
     YYQGVYSRPI MNSS