ID   FOXA3_BOVIN             Reviewed;         351 AA.
AC   Q3Y598; Q1JQB7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Hepatocyte nuclear factor 3-gamma;
DE            Short=HNF-3-gamma;
DE            Short=HNF-3G;
DE   AltName: Full=Forkhead box protein A3;
GN   Name=FOXA3; Synonyms=HNF3G;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Wang Y., Eleswarapu S., Jiang H.;
RT   "Cloning and characterization of the bovine forkhead box A3 (FOXA3) mRNA
RT   and promoter.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription activator for a number of liver genes such as
CC       AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the
CC       cis-acting regulatory regions of these genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; DQ157763; AAZ81946.1; -; mRNA.
DR   EMBL; BC116076; AAI16077.1; -; mRNA.
DR   RefSeq; NP_001028291.1; NM_001033119.2.
DR   AlphaFoldDB; Q3Y598; -.
DR   SMR; Q3Y598; -.
DR   STRING; 9913.ENSBTAP00000016056; -.
DR   PaxDb; Q3Y598; -.
DR   Ensembl; ENSBTAT00000016056; ENSBTAP00000016056; ENSBTAG00000012104.
DR   GeneID; 503622; -.
DR   KEGG; bta:503622; -.
DR   CTD; 3171; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012104; -.
DR   VGNC; VGNC:29079; FOXA3.
DR   eggNOG; KOG3563; Eukaryota.
DR   GeneTree; ENSGT00940000162453; -.
DR   HOGENOM; CLU_027910_0_0_1; -.
DR   InParanoid; Q3Y598; -.
DR   OMA; NNLMSEP; -.
DR   OrthoDB; 1181467at2759; -.
DR   TreeFam; TF316127; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000012104; Expressed in abomasum and 56 other tissues.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR   GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR013638; Fork-head_N.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF08430; Forkhead_N; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..351
FT                   /note="Hepatocyte nuclear factor 3-gamma"
FT                   /id="PRO_0000091799"
FT   DNA_BIND        118..212
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          52..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..75
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  37138 MW;  38EB77150F6F9D5A CRC64;
     MLGSVKMEAH DLAEWSYYPE AGEVYSPVTP VPTMAPLNSY MTLNPLSSPY PPGGLPASPL
     PTGPLAPPAP TAPLGPTFPG LGASTGGGSS SGYGGPGPGL VHGKEMPKGY RRPLAHAKPP
     YSYISLITMA IQQAPGKMLT LSEIYQWIMD LFPYYRENQQ RWQNSIRHSL SFNDCFVKVA
     RSPDKPGKGS YWALHPSSGN MFENGCYLRR QKRFKLEEKV KKGGGGSSAS RNSAGSASTA
     TAPAATVAST PQPQPPPPEP EAQGGDEVGA LDCGSPAAPS TPYFTGLELP GELKLDAPYN
     FNHPFSINNL MSEQSPAPPK LDVGFGGYGA EGGEPGVYYQ GLYSRSLLNA S