FOXB1_HUMAN
ID FOXB1_HUMAN Reviewed; 325 AA.
AC Q99853; O60652; O75917; Q14CL2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Forkhead box protein B1;
DE AltName: Full=Transcription factor FKH-5;
GN Name=FOXB1; Synonyms=FKH5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Bingle C.D.;
RT "Molecular cloning of human Fkh5 from a SCLC line.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RA Cascio S.M., Dodd K.A., Hicks J., Chow S., Brown C.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-173.
RC TISSUE=Lung;
RA Bingle C.D., Gowan S.;
RT "HNF-3/forkhead gene expression in human pulmonary cell lines: molecular
RT cloning of a novel human HNF-3/forkhead cDNA.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q99853; Q15323: KRT31; NbExp=3; IntAct=EBI-3916225, EBI-948001;
CC Q99853; Q6A162: KRT40; NbExp=3; IntAct=EBI-3916225, EBI-10171697;
CC Q99853; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-3916225, EBI-10171774;
CC Q99853; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-3916225, EBI-945833;
CC Q99853; P14373: TRIM27; NbExp=3; IntAct=EBI-3916225, EBI-719493;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR EMBL; AF071554; AAC62493.1; -; mRNA.
DR EMBL; AF055080; AAC09344.1; -; Genomic_DNA.
DR EMBL; AK290944; BAF83633.1; -; mRNA.
DR EMBL; CH471082; EAW77581.1; -; Genomic_DNA.
DR EMBL; BC113710; AAI13711.1; -; mRNA.
DR EMBL; U87393; AAB47564.1; -; mRNA.
DR CCDS; CCDS32255.1; -.
DR RefSeq; NP_036314.2; NM_012182.2.
DR AlphaFoldDB; Q99853; -.
DR SMR; Q99853; -.
DR BioGRID; 117960; 133.
DR IntAct; Q99853; 128.
DR MINT; Q99853; -.
DR STRING; 9606.ENSP00000379369; -.
DR iPTMnet; Q99853; -.
DR PhosphoSitePlus; Q99853; -.
DR BioMuta; FOXB1; -.
DR DMDM; 215274160; -.
DR MassIVE; Q99853; -.
DR PaxDb; Q99853; -.
DR PeptideAtlas; Q99853; -.
DR PRIDE; Q99853; -.
DR ProteomicsDB; 78505; -.
DR Antibodypedia; 12956; 155 antibodies from 33 providers.
DR DNASU; 27023; -.
DR Ensembl; ENST00000396057.6; ENSP00000379369.4; ENSG00000171956.7.
DR GeneID; 27023; -.
DR KEGG; hsa:27023; -.
DR MANE-Select; ENST00000396057.6; ENSP00000379369.4; NM_012182.3; NP_036314.2.
DR UCSC; uc002agj.2; human.
DR CTD; 27023; -.
DR DisGeNET; 27023; -.
DR GeneCards; FOXB1; -.
DR HGNC; HGNC:3799; FOXB1.
DR HPA; ENSG00000171956; Tissue enriched (brain).
DR neXtProt; NX_Q99853; -.
DR OpenTargets; ENSG00000171956; -.
DR PharmGKB; PA28216; -.
DR VEuPathDB; HostDB:ENSG00000171956; -.
DR eggNOG; KOG3562; Eukaryota.
DR GeneTree; ENSGT00940000160522; -.
DR HOGENOM; CLU_040357_2_0_1; -.
DR InParanoid; Q99853; -.
DR OMA; HMYSTSV; -.
DR OrthoDB; 1236900at2759; -.
DR PhylomeDB; Q99853; -.
DR TreeFam; TF350628; -.
DR PathwayCommons; Q99853; -.
DR SignaLink; Q99853; -.
DR BioGRID-ORCS; 27023; 9 hits in 1088 CRISPR screens.
DR ChiTaRS; FOXB1; human.
DR GenomeRNAi; 27023; -.
DR Pharos; Q99853; Tbio.
DR PRO; PR:Q99853; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q99853; protein.
DR Bgee; ENSG00000171956; Expressed in hypothalamus and 51 other tissues.
DR Genevisible; Q99853; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007412; P:axon target recognition; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0061381; P:cell migration in diencephalon; ISS:UniProtKB.
DR GO; GO:0061030; P:epithelial cell differentiation involved in mammary gland alveolus development; ISS:UniProtKB.
DR GO; GO:0033504; P:floor plate development; ISS:UniProtKB.
DR GO; GO:0021855; P:hypothalamus cell migration; ISS:UniProtKB.
DR GO; GO:0061379; P:inferior colliculus development; ISS:UniProtKB.
DR GO; GO:0007595; P:lactation; ISS:UniProtKB.
DR GO; GO:0061377; P:mammary gland lobule development; ISS:UniProtKB.
DR GO; GO:0021767; P:mammillary body development; ISS:UniProtKB.
DR GO; GO:0061374; P:mammillothalamic axonal tract development; ISS:UniProtKB.
DR GO; GO:0030901; P:midbrain development; ISS:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001756; P:somitogenesis; ISS:UniProtKB.
DR GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
DR GO; GO:0022029; P:telencephalon cell migration; ISS:UniProtKB.
DR GO; GO:0021794; P:thalamus development; IEA:Ensembl.
DR GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; ISS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..325
FT /note="Forkhead box protein B1"
FT /id="PRO_0000091803"
FT DNA_BIND 12..103
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 284..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 65
FT /note="L -> F (in Ref. 2; AAC09344)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="R -> C (in Ref. 1; AAC62493 and 6; AAB47564)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="Missing (in Ref. 1; AAC62493, 2; AAC09344 and 6;
FT AAB47564)"
FT /evidence="ECO:0000305"
FT CONFLICT 171..173
FT /note="AIE -> SIN (in Ref. 6; AAB47564)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 34978 MW; FAEE1B16B1997CB0 CRC64;
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY RENTQRWQNS
LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG SFLRRRKRFK VLKSDHLAPS
KPADAAQYLQ QQAKLRLSAL AASGTHLPQM PAAAYNLGGV AQPSGFKHPF AIENIIAREY
KMPGGLAFSA MQPVPAAYPL PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA
YGVPLKPLCH AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
SQSSPATPSE TLTSPASALH SVAVH
