FOXB1_MOUSE
ID FOXB1_MOUSE Reviewed; 325 AA.
AC Q64732; O08753; Q2M2M4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Forkhead box protein B1;
DE AltName: Full=Transcription factor FKH-5;
GN Name=Foxb1; Synonyms=Fkh5, Foxb1a, Foxb1b, Mf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8861101; DOI=10.1016/0925-4773(96)00507-2;
RA Kaestner K.H., Schuetz G., Monaghan A.P.;
RT "Expression of the winged helix genes fkh-4 and fkh-5 defines domains in
RT the central nervous system.";
RL Mech. Dev. 55:221-230(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6 X CBA; TISSUE=Thymocyte;
RA Li S.C., Lai E.;
RT "A winged helix gene expressed in thymocytes.";
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-68.
RX PubMed=8306889; DOI=10.1242/dev.119.4.1301;
RA Ang S.-L., Wierda A., Wong D., Stevens K.A., Cascio S., Rossant J.,
RA Zaret K.S.;
RT "The formation and maintenance of the definitive endoderm lineage in the
RT mouse: involvement of HNF3/forkhead proteins.";
RL Development 119:1301-1315(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-114.
RC STRAIN=129;
RX PubMed=7689224; DOI=10.1073/pnas.90.16.7628;
RA Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P.,
RA Schuetz G.;
RT "Six members of the mouse forkhead gene family are developmentally
RT regulated.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993).
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; X92592; CAA63336.1; -; mRNA.
DR EMBL; U90538; AAB57686.1; -; mRNA.
DR EMBL; BC111908; AAI11909.1; -; mRNA.
DR EMBL; U04198; AAD12223.1; -; mRNA.
DR EMBL; X71943; CAA50745.1; -; Genomic_DNA.
DR CCDS; CCDS40677.1; -.
DR PIR; E47746; E47746.
DR RefSeq; NP_071773.2; NM_022378.3.
DR AlphaFoldDB; Q64732; -.
DR SMR; Q64732; -.
DR BioGRID; 211052; 1.
DR IntAct; Q64732; 1.
DR STRING; 10090.ENSMUSP00000096197; -.
DR PhosphoSitePlus; Q64732; -.
DR PaxDb; Q64732; -.
DR PRIDE; Q64732; -.
DR Antibodypedia; 12956; 155 antibodies from 33 providers.
DR DNASU; 64290; -.
DR Ensembl; ENSMUST00000071281; ENSMUSP00000096197; ENSMUSG00000059246.
DR GeneID; 64290; -.
DR KEGG; mmu:64290; -.
DR UCSC; uc012gwj.1; mouse.
DR CTD; 27023; -.
DR MGI; MGI:1927549; Foxb1.
DR VEuPathDB; HostDB:ENSMUSG00000059246; -.
DR eggNOG; KOG3562; Eukaryota.
DR GeneTree; ENSGT00940000160522; -.
DR HOGENOM; CLU_040357_2_0_1; -.
DR InParanoid; Q64732; -.
DR OMA; HMYSTSV; -.
DR OrthoDB; 1236900at2759; -.
DR PhylomeDB; Q64732; -.
DR TreeFam; TF350628; -.
DR BioGRID-ORCS; 64290; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q64732; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q64732; protein.
DR Bgee; ENSMUSG00000059246; Expressed in embryonic post-anal tail and 49 other tissues.
DR Genevisible; Q64732; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007412; P:axon target recognition; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0061381; P:cell migration in diencephalon; IMP:UniProtKB.
DR GO; GO:0061030; P:epithelial cell differentiation involved in mammary gland alveolus development; IMP:UniProtKB.
DR GO; GO:0033504; P:floor plate development; IMP:UniProtKB.
DR GO; GO:0021855; P:hypothalamus cell migration; IMP:UniProtKB.
DR GO; GO:0061379; P:inferior colliculus development; IMP:UniProtKB.
DR GO; GO:0007595; P:lactation; IMP:UniProtKB.
DR GO; GO:0061377; P:mammary gland lobule development; IMP:UniProtKB.
DR GO; GO:0021767; P:mammillary body development; IMP:UniProtKB.
DR GO; GO:0061374; P:mammillothalamic axonal tract development; IMP:UniProtKB.
DR GO; GO:0030901; P:midbrain development; IMP:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001756; P:somitogenesis; IMP:UniProtKB.
DR GO; GO:0021510; P:spinal cord development; IEP:UniProtKB.
DR GO; GO:0022029; P:telencephalon cell migration; IMP:UniProtKB.
DR GO; GO:0021794; P:thalamus development; IEP:UniProtKB.
DR GO; GO:0001655; P:urogenital system development; IEP:UniProtKB.
DR GO; GO:0008542; P:visual learning; IMP:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..325
FT /note="Forkhead box protein B1"
FT /id="PRO_0000091804"
FT DNA_BIND 12..103
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 284..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 63..68
FT /note="HNLSFN -> PLTVRH (in Ref. 4; AAD12223)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="Missing (in Ref. 1; CAA63336)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 35008 MW; E7456B02F48D2DF5 CRC64;
MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY RENTQRWQNS
LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG SFLRRRKRFK VLKSDHLAPS
KPADAAQYLQ QQAKLRLSAL AASGTHLPQM PAAAYNLGGV AQPSGFKHPF AIENIIAREY
KMPGGLAFSA MQPVPAAYPL PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMTSGDYSA
YGVPLKPLCH AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT
SQSSPATPSE TLTSPASALH SVAVH
